Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dihydroxy-acid dehydratase

Gene

ilvD

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi122 – 1221Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi195 – 1951Iron-sulfur (4Fe-4S)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00047; UER00057.
UPA00049; UER00061.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroxy-acid dehydrataseUniRule annotation (EC:4.2.1.9UniRule annotation)
Short name:
DADUniRule annotation
Gene namesi
Name:ilvDUniRule annotation
Ordered Locus Names:HI_0738
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 612612Dihydroxy-acid dehydratasePRO_0000103469Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0738.

Family & Domainsi

Sequence similaritiesi

Belongs to the IlvD/Edd family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0129.
KOiK01687.
OMAiQGRNMAG.
OrthoDBiEOG6MSS24.
PhylomeDBiP44851.

Family and domain databases

HAMAPiMF_00012. IlvD.
InterProiIPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
PANTHERiPTHR21000. PTHR21000. 1 hit.
PfamiPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMiSSF52016. SSF52016. 1 hit.
TIGRFAMsiTIGR00110. ilvD. 1 hit.
PROSITEiPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44851-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKLRSATST QGRNMAGARA LWRATGMKEN DFGKPIIAVV NSFTQFVPGH
60 70 80 90 100
VHLKDMGQLV AAEIEKAGGV AKEFNTIAVD DGIAMGHGGM LYSLPSRDLI
110 120 130 140 150
ADSVEYMVNA HCADAMVCIS NCDKITPGML MAAMRLNIPT IFVSGGPMEA
160 170 180 190 200
GKTKLSDQLI RLDLVDAMIE AADPNVSDER IDAIERSACP TCGSCSGMFT
210 220 230 240 250
ANSMNCLTEA LGLSLPGNGS MLATHADRKE LFLKAGRQIV ELCKRYYEQD
260 270 280 290 300
DASVLPRSIG TFDAFENAMS LDIAMGGSSN TVLHLLAAAQ EAGVDFKMED
310 320 330 340 350
IDRLSRKVPC LSKIAPNTNK YHMEDVHRAG GIMGLLGELD RAGLIHKNTH
360 370 380 390 400
TVLGMSMGEQ LDQYDIIRNQ DEELHKFFRA GPAGIRTTQA FSQDCRWDTV
410 420 430 440 450
DNDRVNGCIR NKENAISQEG GLAVLFGNLA EDGCIVKTAG VDESIWKFTG
460 470 480 490 500
TAIVFESQED AVAGILGGKV KEGHVVVIRY EGPKGGPGMQ EMLYPTSYLK
510 520 530 540 550
SMGLGKKCAL LTDGRFSGGT SGLSIGHVSP EAASGGAIGL VRNGDIINID
560 570 580 590 600
IPNRAINLEI SNEELATRRA EQDQKGWQPA NREREVSFAL KVFGHFATSA
610
DKGAVRDKTL LK
Length:612
Mass (Da):65,823
Last modified:November 1, 1995 - v1
Checksum:i42CE1C8F7E0A09A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22397.1.
PIRiG64089.
RefSeqiNP_438897.1. NC_000907.1.
WP_005693142.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22397; AAC22397; HI_0738.
GeneIDi949825.
KEGGihin:HI0738.
PATRICi20190117. VBIHaeInf48452_0774.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22397.1.
PIRiG64089.
RefSeqiNP_438897.1. NC_000907.1.
WP_005693142.1. NC_000907.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0738.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22397; AAC22397; HI_0738.
GeneIDi949825.
KEGGihin:HI0738.
PATRICi20190117. VBIHaeInf48452_0774.

Phylogenomic databases

eggNOGiCOG0129.
KOiK01687.
OMAiQGRNMAG.
OrthoDBiEOG6MSS24.
PhylomeDBiP44851.

Enzyme and pathway databases

UniPathwayiUPA00047; UER00057.
UPA00049; UER00061.

Family and domain databases

HAMAPiMF_00012. IlvD.
InterProiIPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
PANTHERiPTHR21000. PTHR21000. 1 hit.
PfamiPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMiSSF52016. SSF52016. 1 hit.
TIGRFAMsiTIGR00110. ilvD. 1 hit.
PROSITEiPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiILVD_HAEIN
AccessioniPrimary (citable) accession number: P44851
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 27, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.