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P44851

- ILVD_HAEIN

UniProt

P44851 - ILVD_HAEIN

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Protein

Dihydroxy-acid dehydratase

Gene

ilvD

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.UniRule annotation

Cofactori

Binds 1 4Fe-4S cluster.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi122 – 1221Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi195 – 1951Iron-sulfur (4Fe-4S)UniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. dihydroxy-acid dehydratase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
  2. valine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00047; UER00057.
UPA00049; UER00061.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroxy-acid dehydrataseUniRule annotation (EC:4.2.1.9UniRule annotation)
Short name:
DADUniRule annotation
Gene namesi
Name:ilvDUniRule annotation
Ordered Locus Names:HI_0738
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 612612Dihydroxy-acid dehydratasePRO_0000103469Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0738.

Family & Domainsi

Sequence similaritiesi

Belongs to the IlvD/Edd family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0129.
KOiK01687.
OMAiTPMEFNT.
OrthoDBiEOG6MSS24.
PhylomeDBiP44851.

Family and domain databases

HAMAPiMF_00012. IlvD.
InterProiIPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
PANTHERiPTHR21000. PTHR21000. 1 hit.
PfamiPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMiSSF52016. SSF52016. 1 hit.
TIGRFAMsiTIGR00110. ilvD. 1 hit.
PROSITEiPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44851-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKLRSATST QGRNMAGARA LWRATGMKEN DFGKPIIAVV NSFTQFVPGH
60 70 80 90 100
VHLKDMGQLV AAEIEKAGGV AKEFNTIAVD DGIAMGHGGM LYSLPSRDLI
110 120 130 140 150
ADSVEYMVNA HCADAMVCIS NCDKITPGML MAAMRLNIPT IFVSGGPMEA
160 170 180 190 200
GKTKLSDQLI RLDLVDAMIE AADPNVSDER IDAIERSACP TCGSCSGMFT
210 220 230 240 250
ANSMNCLTEA LGLSLPGNGS MLATHADRKE LFLKAGRQIV ELCKRYYEQD
260 270 280 290 300
DASVLPRSIG TFDAFENAMS LDIAMGGSSN TVLHLLAAAQ EAGVDFKMED
310 320 330 340 350
IDRLSRKVPC LSKIAPNTNK YHMEDVHRAG GIMGLLGELD RAGLIHKNTH
360 370 380 390 400
TVLGMSMGEQ LDQYDIIRNQ DEELHKFFRA GPAGIRTTQA FSQDCRWDTV
410 420 430 440 450
DNDRVNGCIR NKENAISQEG GLAVLFGNLA EDGCIVKTAG VDESIWKFTG
460 470 480 490 500
TAIVFESQED AVAGILGGKV KEGHVVVIRY EGPKGGPGMQ EMLYPTSYLK
510 520 530 540 550
SMGLGKKCAL LTDGRFSGGT SGLSIGHVSP EAASGGAIGL VRNGDIINID
560 570 580 590 600
IPNRAINLEI SNEELATRRA EQDQKGWQPA NREREVSFAL KVFGHFATSA
610
DKGAVRDKTL LK
Length:612
Mass (Da):65,823
Last modified:November 1, 1995 - v1
Checksum:i42CE1C8F7E0A09A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22397.1.
PIRiG64089.
RefSeqiNP_438897.1. NC_000907.1.
WP_005693142.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22397; AAC22397; HI_0738.
GeneIDi949825.
KEGGihin:HI0738.
PATRICi20190117. VBIHaeInf48452_0774.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22397.1 .
PIRi G64089.
RefSeqi NP_438897.1. NC_000907.1.
WP_005693142.1. NC_000907.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0738.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22397 ; AAC22397 ; HI_0738 .
GeneIDi 949825.
KEGGi hin:HI0738.
PATRICi 20190117. VBIHaeInf48452_0774.

Phylogenomic databases

eggNOGi COG0129.
KOi K01687.
OMAi TPMEFNT.
OrthoDBi EOG6MSS24.
PhylomeDBi P44851.

Enzyme and pathway databases

UniPathwayi UPA00047 ; UER00057 .
UPA00049 ; UER00061 .

Family and domain databases

HAMAPi MF_00012. IlvD.
InterProi IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view ]
PANTHERi PTHR21000. PTHR21000. 1 hit.
Pfami PF00920. ILVD_EDD. 1 hit.
[Graphical view ]
SUPFAMi SSF52016. SSF52016. 1 hit.
TIGRFAMsi TIGR00110. ilvD. 1 hit.
PROSITEi PS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiILVD_HAEIN
AccessioniPrimary (citable) accession number: P44851
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 1, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3