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P44851 (ILVD_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydroxy-acid dehydratase

Short name=DAD
EC=4.2.1.9
Gene names
Name:ilvD
Ordered Locus Names:HI_0738
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length612 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. HAMAP-Rule MF_00012

Cofactor

Binds 1 4Fe-4S cluster Potential.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4. HAMAP-Rule MF_00012

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4. HAMAP-Rule MF_00012

Sequence similarities

Belongs to the IlvD/Edd family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 612612Dihydroxy-acid dehydratase HAMAP-Rule MF_00012
PRO_0000103469

Sites

Metal binding1221Iron-sulfur (4Fe-4S) Potential
Metal binding1951Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
P44851 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 42CE1C8F7E0A09A1

FASTA61265,823
        10         20         30         40         50         60 
MPKLRSATST QGRNMAGARA LWRATGMKEN DFGKPIIAVV NSFTQFVPGH VHLKDMGQLV 

        70         80         90        100        110        120 
AAEIEKAGGV AKEFNTIAVD DGIAMGHGGM LYSLPSRDLI ADSVEYMVNA HCADAMVCIS 

       130        140        150        160        170        180 
NCDKITPGML MAAMRLNIPT IFVSGGPMEA GKTKLSDQLI RLDLVDAMIE AADPNVSDER 

       190        200        210        220        230        240 
IDAIERSACP TCGSCSGMFT ANSMNCLTEA LGLSLPGNGS MLATHADRKE LFLKAGRQIV 

       250        260        270        280        290        300 
ELCKRYYEQD DASVLPRSIG TFDAFENAMS LDIAMGGSSN TVLHLLAAAQ EAGVDFKMED 

       310        320        330        340        350        360 
IDRLSRKVPC LSKIAPNTNK YHMEDVHRAG GIMGLLGELD RAGLIHKNTH TVLGMSMGEQ 

       370        380        390        400        410        420 
LDQYDIIRNQ DEELHKFFRA GPAGIRTTQA FSQDCRWDTV DNDRVNGCIR NKENAISQEG 

       430        440        450        460        470        480 
GLAVLFGNLA EDGCIVKTAG VDESIWKFTG TAIVFESQED AVAGILGGKV KEGHVVVIRY 

       490        500        510        520        530        540 
EGPKGGPGMQ EMLYPTSYLK SMGLGKKCAL LTDGRFSGGT SGLSIGHVSP EAASGGAIGL 

       550        560        570        580        590        600 
VRNGDIINID IPNRAINLEI SNEELATRRA EQDQKGWQPA NREREVSFAL KVFGHFATSA 

       610 
DKGAVRDKTL LK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22397.1.
PIRG64089.
RefSeqNP_438897.1. NC_000907.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0738.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22397; AAC22397; HI_0738.
GeneID949825.
KEGGhin:HI0738.
PATRIC20190117. VBIHaeInf48452_0774.

Phylogenomic databases

eggNOGCOG0129.
KOK01687.
OMAIPGHVHL.
OrthoDBEOG6MSS24.
ProtClustDBPRK12448.

Enzyme and pathway databases

UniPathwayUPA00047; UER00057.
UPA00049; UER00061.

Family and domain databases

HAMAPMF_00012. IlvD.
InterProIPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
PANTHERPTHR21000. PTHR21000. 1 hit.
PfamPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMSSF52016. SSF52016. 1 hit.
TIGRFAMsTIGR00110. ilvD. 1 hit.
PROSITEPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameILVD_HAEIN
AccessionPrimary (citable) accession number: P44851
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 19, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names