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P44851

- ILVD_HAEIN

UniProt

P44851 - ILVD_HAEIN

Protein

Dihydroxy-acid dehydratase

Gene

ilvD

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.UniRule annotation

    Cofactori

    Binds 1 4Fe-4S cluster.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi122 – 1221Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi195 – 1951Iron-sulfur (4Fe-4S)UniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. dihydroxy-acid dehydratase activity Source: UniProtKB-HAMAP
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
    2. valine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00047; UER00057.
    UPA00049; UER00061.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydroxy-acid dehydrataseUniRule annotation (EC:4.2.1.9UniRule annotation)
    Short name:
    DADUniRule annotation
    Gene namesi
    Name:ilvDUniRule annotation
    Ordered Locus Names:HI_0738
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 612612Dihydroxy-acid dehydratasePRO_0000103469Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0738.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IlvD/Edd family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0129.
    KOiK01687.
    OMAiTPMEFNT.
    OrthoDBiEOG6MSS24.
    PhylomeDBiP44851.

    Family and domain databases

    HAMAPiMF_00012. IlvD.
    InterProiIPR015928. Aconitase/3IPM_dehydase_swvl.
    IPR004404. DihydroxyA_deHydtase.
    IPR000581. DiOHA_6PGluconate_deHydtase.
    IPR020558. DiOHA_6PGluconate_deHydtase_CS.
    [Graphical view]
    PANTHERiPTHR21000. PTHR21000. 1 hit.
    PfamiPF00920. ILVD_EDD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52016. SSF52016. 1 hit.
    TIGRFAMsiTIGR00110. ilvD. 1 hit.
    PROSITEiPS00886. ILVD_EDD_1. 1 hit.
    PS00887. ILVD_EDD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P44851-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKLRSATST QGRNMAGARA LWRATGMKEN DFGKPIIAVV NSFTQFVPGH    50
    VHLKDMGQLV AAEIEKAGGV AKEFNTIAVD DGIAMGHGGM LYSLPSRDLI 100
    ADSVEYMVNA HCADAMVCIS NCDKITPGML MAAMRLNIPT IFVSGGPMEA 150
    GKTKLSDQLI RLDLVDAMIE AADPNVSDER IDAIERSACP TCGSCSGMFT 200
    ANSMNCLTEA LGLSLPGNGS MLATHADRKE LFLKAGRQIV ELCKRYYEQD 250
    DASVLPRSIG TFDAFENAMS LDIAMGGSSN TVLHLLAAAQ EAGVDFKMED 300
    IDRLSRKVPC LSKIAPNTNK YHMEDVHRAG GIMGLLGELD RAGLIHKNTH 350
    TVLGMSMGEQ LDQYDIIRNQ DEELHKFFRA GPAGIRTTQA FSQDCRWDTV 400
    DNDRVNGCIR NKENAISQEG GLAVLFGNLA EDGCIVKTAG VDESIWKFTG 450
    TAIVFESQED AVAGILGGKV KEGHVVVIRY EGPKGGPGMQ EMLYPTSYLK 500
    SMGLGKKCAL LTDGRFSGGT SGLSIGHVSP EAASGGAIGL VRNGDIINID 550
    IPNRAINLEI SNEELATRRA EQDQKGWQPA NREREVSFAL KVFGHFATSA 600
    DKGAVRDKTL LK 612
    Length:612
    Mass (Da):65,823
    Last modified:November 1, 1995 - v1
    Checksum:i42CE1C8F7E0A09A1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22397.1.
    PIRiG64089.
    RefSeqiNP_438897.1. NC_000907.1.
    WP_005693142.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22397; AAC22397; HI_0738.
    GeneIDi949825.
    KEGGihin:HI0738.
    PATRICi20190117. VBIHaeInf48452_0774.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22397.1 .
    PIRi G64089.
    RefSeqi NP_438897.1. NC_000907.1.
    WP_005693142.1. NC_000907.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0738.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22397 ; AAC22397 ; HI_0738 .
    GeneIDi 949825.
    KEGGi hin:HI0738.
    PATRICi 20190117. VBIHaeInf48452_0774.

    Phylogenomic databases

    eggNOGi COG0129.
    KOi K01687.
    OMAi TPMEFNT.
    OrthoDBi EOG6MSS24.
    PhylomeDBi P44851.

    Enzyme and pathway databases

    UniPathwayi UPA00047 ; UER00057 .
    UPA00049 ; UER00061 .

    Family and domain databases

    HAMAPi MF_00012. IlvD.
    InterProi IPR015928. Aconitase/3IPM_dehydase_swvl.
    IPR004404. DihydroxyA_deHydtase.
    IPR000581. DiOHA_6PGluconate_deHydtase.
    IPR020558. DiOHA_6PGluconate_deHydtase_CS.
    [Graphical view ]
    PANTHERi PTHR21000. PTHR21000. 1 hit.
    Pfami PF00920. ILVD_EDD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52016. SSF52016. 1 hit.
    TIGRFAMsi TIGR00110. ilvD. 1 hit.
    PROSITEi PS00886. ILVD_EDD_1. 1 hit.
    PS00887. ILVD_EDD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiILVD_HAEIN
    AccessioniPrimary (citable) accession number: P44851
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3