SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P44851

- ILVD_HAEIN

UniProt

P44851 - ILVD_HAEIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Dihydroxy-acid dehydratase

Gene
ilvD, HI_0738
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.UniRule annotation

Cofactori

Binds 1 4Fe-4S cluster Reviewed prediction.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi122 – 1221Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi195 – 1951Iron-sulfur (4Fe-4S) Reviewed prediction

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. dihydroxy-acid dehydratase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
  2. valine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00047; UER00057.
UPA00049; UER00061.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroxy-acid dehydratase (EC:4.2.1.9)
Short name:
DAD
Gene namesi
Name:ilvD
Ordered Locus Names:HI_0738
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 612612Dihydroxy-acid dehydrataseUniRule annotationPRO_0000103469Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0738.

Family & Domainsi

Sequence similaritiesi

Belongs to the IlvD/Edd family.

Phylogenomic databases

eggNOGiCOG0129.
KOiK01687.
OMAiTPMEFNT.
OrthoDBiEOG6MSS24.
PhylomeDBiP44851.

Family and domain databases

HAMAPiMF_00012. IlvD.
InterProiIPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
PANTHERiPTHR21000. PTHR21000. 1 hit.
PfamiPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMiSSF52016. SSF52016. 1 hit.
TIGRFAMsiTIGR00110. ilvD. 1 hit.
PROSITEiPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44851-1 [UniParc]FASTAAdd to Basket

« Hide

MPKLRSATST QGRNMAGARA LWRATGMKEN DFGKPIIAVV NSFTQFVPGH    50
VHLKDMGQLV AAEIEKAGGV AKEFNTIAVD DGIAMGHGGM LYSLPSRDLI 100
ADSVEYMVNA HCADAMVCIS NCDKITPGML MAAMRLNIPT IFVSGGPMEA 150
GKTKLSDQLI RLDLVDAMIE AADPNVSDER IDAIERSACP TCGSCSGMFT 200
ANSMNCLTEA LGLSLPGNGS MLATHADRKE LFLKAGRQIV ELCKRYYEQD 250
DASVLPRSIG TFDAFENAMS LDIAMGGSSN TVLHLLAAAQ EAGVDFKMED 300
IDRLSRKVPC LSKIAPNTNK YHMEDVHRAG GIMGLLGELD RAGLIHKNTH 350
TVLGMSMGEQ LDQYDIIRNQ DEELHKFFRA GPAGIRTTQA FSQDCRWDTV 400
DNDRVNGCIR NKENAISQEG GLAVLFGNLA EDGCIVKTAG VDESIWKFTG 450
TAIVFESQED AVAGILGGKV KEGHVVVIRY EGPKGGPGMQ EMLYPTSYLK 500
SMGLGKKCAL LTDGRFSGGT SGLSIGHVSP EAASGGAIGL VRNGDIINID 550
IPNRAINLEI SNEELATRRA EQDQKGWQPA NREREVSFAL KVFGHFATSA 600
DKGAVRDKTL LK 612
Length:612
Mass (Da):65,823
Last modified:November 1, 1995 - v1
Checksum:i42CE1C8F7E0A09A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22397.1.
PIRiG64089.
RefSeqiNP_438897.1. NC_000907.1.
WP_005693142.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22397; AAC22397; HI_0738.
GeneIDi949825.
KEGGihin:HI0738.
PATRICi20190117. VBIHaeInf48452_0774.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22397.1 .
PIRi G64089.
RefSeqi NP_438897.1. NC_000907.1.
WP_005693142.1. NC_000907.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0738.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22397 ; AAC22397 ; HI_0738 .
GeneIDi 949825.
KEGGi hin:HI0738.
PATRICi 20190117. VBIHaeInf48452_0774.

Phylogenomic databases

eggNOGi COG0129.
KOi K01687.
OMAi TPMEFNT.
OrthoDBi EOG6MSS24.
PhylomeDBi P44851.

Enzyme and pathway databases

UniPathwayi UPA00047 ; UER00057 .
UPA00049 ; UER00061 .

Family and domain databases

HAMAPi MF_00012. IlvD.
InterProi IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view ]
PANTHERi PTHR21000. PTHR21000. 1 hit.
Pfami PF00920. ILVD_EDD. 1 hit.
[Graphical view ]
SUPFAMi SSF52016. SSF52016. 1 hit.
TIGRFAMsi TIGR00110. ilvD. 1 hit.
PROSITEi PS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiILVD_HAEIN
AccessioniPrimary (citable) accession number: P44851
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi