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Protein

ATP-dependent Clp protease ATP-binding subunit ClpX

Gene

clpX

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri10 – 35C4-typeUniRule annotationAdd BLAST26
Nucleotide bindingi118 – 125ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-749-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpXUniRule annotation
Gene namesi
Name:clpXUniRule annotation
Ordered Locus Names:HI_0715
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001603631 – 411ATP-dependent Clp protease ATP-binding subunit ClpXAdd BLAST411

Proteomic databases

PRIDEiP44838

Interactioni

Subunit structurei

Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi71421.HI0715

Structurei

3D structure databases

ProteinModelPortaliP44838
SMRiP44838
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpX chaperone family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri10 – 35C4-typeUniRule annotationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG4105CHN Bacteria
COG1219 LUCA
KOiK03544
OMAiDIMYDLP
PhylomeDBiP44838

Family and domain databases

Gene3Di3.30.50.30, 1 hit
HAMAPiMF_00175 ClpX, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR019489 Clp_ATPase_C
IPR004487 Clp_protease_ATP-bd_su_ClpX
IPR027417 P-loop_NTPase
IPR010603 Znf_CppX_C4
IPR038366 Znf_CppX_C4_sf
PANTHERiPTHR11262 PTHR11262, 2 hits
PfamiView protein in Pfam
PF07724 AAA_2, 1 hit
PF10431 ClpB_D2-small, 1 hit
PF06689 zf-C4_ClpX, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM01086 ClpB_D2-small, 1 hit
SM00994 zf-C4_ClpX, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00382 clpX, 1 hit

Sequencei

Sequence statusi: Complete.

P44838-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDKDKDLHC SFCGKEKGEV DRLIAGTDGY ICNECIELCH SMLEESHDKN
60 70 80 90 100
LEESAVENEE KLPTPHEIRA HLDDYVIGQD YAKKVLSVAV YNHYKRLRTN
110 120 130 140 150
YESNDVELGK SNILLIGPTG SGKTLLAQTL ARRLNVPFAM ADATTLTEAG
160 170 180 190 200
YVGEDVENVL QKLLQNCEYD TEKAEKGIIY IDEIDKISRK SEGASITRDV
210 220 230 240 250
SGEGVQQALL KLIEGTIASI PPQGGRKHPQ QEMVKLDTSK ILFICGGAFA
260 270 280 290 300
GLDKIIDKRT QTSTSIGFNA KVEKDEKQQS LSELFRQVEP DDLMKFGLIP
310 320 330 340 350
EFIGRLPMIA PLSELDEDAL IQILTKPKNA LIKQYQALFG LEKVELDFTP
360 370 380 390 400
EALKAMAKKA LERKTGARGL RSIVEAVLLD TMYDLPSLEN LQKVIVDEST
410
IVDNLAPKLE Y
Length:411
Mass (Da):45,733
Last modified:November 1, 1995 - v1
Checksum:i6C8F4ACEA154FA2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC22372.1
PIRiE64088
RefSeqiNP_438873.1, NC_000907.1
WP_005661954.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC22372; AAC22372; HI_0715
GeneIDi949862
KEGGihin:HI0715
PATRICifig|71421.8.peg.747

Similar proteinsi

Entry informationi

Entry nameiCLPX_HAEIN
AccessioniPrimary (citable) accession number: P44838
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health