P44838 (CLPX_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpX

Gene names

Name:	clpX
Ordered Locus Names:	HI_0715

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	411 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP By similarity. HAMAP-Rule MF_00175
Subunit structure	Heterodimer of ClpP and ClpX By similarity.
Sequence similarities	Belongs to the ClpX chaperone family.

Ontologies

Keywords
Domain	Zinc-finger
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 411	411	ATP-dependent Clp protease ATP-binding subunit ClpX HAMAP-Rule MF_00175		PRO_0000160363
Regions
	Zinc finger	10 – 35	26	C4-type HAMAP-Rule MF_00175
	Nucleotide binding	117 – 124	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P44838 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 6C8F4ACEA154FA2C	FASTA	411	45,733
	10 20 30 40 50 60 MTDKDKDLHC SFCGKEKGEV DRLIAGTDGY ICNECIELCH SMLEESHDKN LEESAVENEE 70 80 90 100 110 120 KLPTPHEIRA HLDDYVIGQD YAKKVLSVAV YNHYKRLRTN YESNDVELGK SNILLIGPTG 130 140 150 160 170 180 SGKTLLAQTL ARRLNVPFAM ADATTLTEAG YVGEDVENVL QKLLQNCEYD TEKAEKGIIY 190 200 210 220 230 240 IDEIDKISRK SEGASITRDV SGEGVQQALL KLIEGTIASI PPQGGRKHPQ QEMVKLDTSK 250 260 270 280 290 300 ILFICGGAFA GLDKIIDKRT QTSTSIGFNA KVEKDEKQQS LSELFRQVEP DDLMKFGLIP 310 320 330 340 350 360 EFIGRLPMIA PLSELDEDAL IQILTKPKNA LIKQYQALFG LEKVELDFTP EALKAMAKKA 370 380 390 400 410 LERKTGARGL RSIVEAVLLD TMYDLPSLEN LQKVIVDEST IVDNLAPKLE Y

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC22372.1.
PIR	E64088.
RefSeq	NP_438873.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P44838.
SMR	P44838. Positions 8-43.
ModBase	Search...
Protein-protein interaction databases
STRING	71421.HI0715.
Proteomic databases
PRIDE	P44838.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC22372; AAC22372; HI_0715.
GeneID	949862.
KEGG	hin:HI0715.
PATRIC	20190053. VBIHaeInf48452_0747.
Phylogenomic databases
eggNOG	COG1219.
KO	K03544.
OMA	ASINTRN.
ProtClustDB	PRK05342.
Family and domain databases
HAMAP	MF_00175. ClpX.
InterPro	IPR003593. AAA+_ATPase. IPR013093. ATPase_AAA-2. IPR019489. Clp_ATPase_C. IPR004487. Clp_protease_ATP-bd_su_ClpX. IPR010603. Znf_CppX_C4. [Graphical view]
PANTHER	PTHR11262:SF4. PTHR11262:SF4. 1 hit.
Pfam	PF07724. AAA_2. 1 hit. PF10431. ClpB_D2-small. 1 hit. PF06689. zf-C4_ClpX. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. SM01086. ClpB_D2-small. 1 hit. SM00994. zf-C4_ClpX. 1 hit. [Graphical view]
TIGRFAMs	TIGR00382. clpX. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CLPX_HAEIN

Accession

Primary (citable) accession number: P44838

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program