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P44838

- CLPX_HAEIN

UniProt

P44838 - CLPX_HAEIN

Protein

ATP-dependent Clp protease ATP-binding subunit ClpX

Gene

clpX

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri10 – 3526C4-typeUniRule annotationAdd
    BLAST
    Nucleotide bindingi118 – 1258ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. nucleoside-triphosphatase activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein folding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent Clp protease ATP-binding subunit ClpXUniRule annotation
    Gene namesi
    Name:clpXUniRule annotation
    Ordered Locus Names:HI_0715
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 411411ATP-dependent Clp protease ATP-binding subunit ClpXPRO_0000160363Add
    BLAST

    Proteomic databases

    PRIDEiP44838.

    Interactioni

    Subunit structurei

    Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

    Protein-protein interaction databases

    STRINGi71421.HI0715.

    Structurei

    3D structure databases

    ProteinModelPortaliP44838.
    SMRiP44838. Positions 8-43.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ClpX chaperone family.UniRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri10 – 3526C4-typeUniRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1219.
    KOiK03544.
    OMAiILLDIMY.
    OrthoDBiEOG625JZK.
    PhylomeDBiP44838.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_00175. ClpX.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR004487. Clp_protease_ATP-bd_su_ClpX.
    IPR027417. P-loop_NTPase.
    IPR010603. Znf_CppX_C4.
    [Graphical view]
    PfamiPF07724. AAA_2. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    PF06689. zf-C4_ClpX. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM01086. ClpB_D2-small. 1 hit.
    SM00994. zf-C4_ClpX. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00382. clpX. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P44838-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDKDKDLHC SFCGKEKGEV DRLIAGTDGY ICNECIELCH SMLEESHDKN    50
    LEESAVENEE KLPTPHEIRA HLDDYVIGQD YAKKVLSVAV YNHYKRLRTN 100
    YESNDVELGK SNILLIGPTG SGKTLLAQTL ARRLNVPFAM ADATTLTEAG 150
    YVGEDVENVL QKLLQNCEYD TEKAEKGIIY IDEIDKISRK SEGASITRDV 200
    SGEGVQQALL KLIEGTIASI PPQGGRKHPQ QEMVKLDTSK ILFICGGAFA 250
    GLDKIIDKRT QTSTSIGFNA KVEKDEKQQS LSELFRQVEP DDLMKFGLIP 300
    EFIGRLPMIA PLSELDEDAL IQILTKPKNA LIKQYQALFG LEKVELDFTP 350
    EALKAMAKKA LERKTGARGL RSIVEAVLLD TMYDLPSLEN LQKVIVDEST 400
    IVDNLAPKLE Y 411
    Length:411
    Mass (Da):45,733
    Last modified:November 1, 1995 - v1
    Checksum:i6C8F4ACEA154FA2C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22372.1.
    PIRiE64088.
    RefSeqiNP_438873.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22372; AAC22372; HI_0715.
    GeneIDi949862.
    KEGGihin:HI0715.
    PATRICi20190053. VBIHaeInf48452_0747.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22372.1 .
    PIRi E64088.
    RefSeqi NP_438873.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44838.
    SMRi P44838. Positions 8-43.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0715.

    Proteomic databases

    PRIDEi P44838.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22372 ; AAC22372 ; HI_0715 .
    GeneIDi 949862.
    KEGGi hin:HI0715.
    PATRICi 20190053. VBIHaeInf48452_0747.

    Phylogenomic databases

    eggNOGi COG1219.
    KOi K03544.
    OMAi ILLDIMY.
    OrthoDBi EOG625JZK.
    PhylomeDBi P44838.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_00175. ClpX.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR004487. Clp_protease_ATP-bd_su_ClpX.
    IPR027417. P-loop_NTPase.
    IPR010603. Znf_CppX_C4.
    [Graphical view ]
    Pfami PF07724. AAA_2. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    PF06689. zf-C4_ClpX. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM01086. ClpB_D2-small. 1 hit.
    SM00994. zf-C4_ClpX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00382. clpX. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiCLPX_HAEIN
    AccessioniPrimary (citable) accession number: P44838
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3