P44833 (LPPB_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Outer membrane antigenic lipoprotein B

Gene names

Name:	lppB
Ordered Locus Names:	HI_0706

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	405 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May be a virulence determinant.
Subcellular location	Cell outer membrane; Lipid-anchor.
Sequence similarities	Belongs to the E.coli NlpD/Haemophilus LppB family. Contains 1 LysM repeat.

Ontologies

Keywords
Biological process	Virulence
Cellular component	Cell membrane Cell outer membrane Membrane
Domain	Signal
PTM	Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cell outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Probable
	Chain	18 – 405	388	Outer membrane antigenic lipoprotein B		PRO_0000018034
Regions
	Repeat	147 – 190	44	LysM
Amino acid modifications
	Lipidation	18	1	N-palmitoyl cysteine Probable
	Lipidation	18	1	S-diacylglycerol cysteine Probable

Sequences

	Sequence		Length	Mass (Da)
	P44833 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 4134FB6B93EFE57F	FASTA	405	42,505
	10 20 30 40 50 60 MKKSFLLLPL SLVVLSACTS NFPAPISDAD GNFSPSVIQS VNGSNVGGAW QPEIQKNSLP 70 80 90 100 110 120 TTGNMVTPQQ NFQPINQQPT MPTAPAQPAF QPSPKTVVSA PTVQTKTVTK TVADCVDGQH 130 140 150 160 170 180 INIPRNPNTN APDYSKISKG SYKGNTYKVN KGDTMFLIAY LAGIDVKELA ALNNLSEPYN 190 200 210 220 230 240 LSLGQVLKIS NCDIKTVTTT VSVKQPAVTA STATPVKPAV TYTPGANGTQ IGSDGTIIGP 250 260 270 280 290 300 IKSEAGTSPS VPVATSSTQV TSSVNNANST PINSNVVAPI ASNVVWQWPT SGNIIQGFSS 310 320 330 340 350 360 TDGGNKGIDI SGSRGQAVKA AAAGRIVYAG NALRGYGNLI IIKHNDDFLS AYAHNDKILV 370 380 390 400 ADQQEVKAGQ DIAKMGSSGT NTVKLHFEIR YKGKSVDPVR YLPRH

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC22363.1.
PIR	F64087.
RefSeq	NP_438864.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P44833.
ModBase	Search...
Protein-protein interaction databases
STRING	71421.HI0706.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC22363; AAC22363; HI_0706.
GeneID	949731.
KEGG	hin:HI0706.
PATRIC	20190029. VBIHaeInf48452_0736.
Phylogenomic databases
eggNOG	COG0739.
KO	K06194.
OMA	WITGNDY.
ProtClustDB	CLSK892381.
Family and domain databases
InterPro	IPR011055. Dup_hybrid_motif. IPR016047. Peptidase_M23. IPR018392. Peptidoglycan-bd_lysin. IPR002482. Peptidoglycan-bd_Lysin_subgr. [Graphical view]
Pfam	PF01476. LysM. 1 hit. PF01551. Peptidase_M23. 1 hit. [Graphical view]
SMART	SM00257. LysM. 1 hit. [Graphical view]
SUPFAM	SSF51261. Dup_hybrid_motif. 1 hit.
PROSITE	PS51257. PROKAR_LIPOPROTEIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LPPB_HAEIN

Accession

Primary (citable) accession number: P44833

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program