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Protein

Putative exopolyphosphatase

Gene

ppx

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate.

Catalytic activityi

(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.

Cofactori

Mg2+By similarity

GO - Molecular functioni

  1. exopolyphosphatase activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro

GO - Biological processi

  1. polyphosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Putative exopolyphosphatase (EC:3.6.1.11)
Alternative name(s):
Metaphosphatase
Gene namesi
Name:ppx
Ordered Locus Names:HI_0695
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Putative exopolyphosphatasePRO_0000194302Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0695.

Structurei

3D structure databases

ProteinModelPortaliP44828.
SMRiP44828. Positions 16-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family.Curated

Phylogenomic databases

eggNOGiCOG0248.
KOiK01524.
OMAiVANGCIG.
OrthoDBiEOG6M6JN6.
PhylomeDBiP44828.

Family and domain databases

InterProiIPR022371. Exopolyphosphatase.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03706. exo_poly_only. 1 hit.

Sequencei

Sequence statusi: Complete.

P44828-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNDSILEPKH RGNVREIAAI DLGSNSFHMI VARIVNGSIQ VLSRLKQKVK
60 70 80 90 100
LAEGLDENAV LNQEAITRGV NCLALFAERL QGFPMENVNV VGTYTLRRAV
110 120 130 140 150
NNDEFLRQAA KVFPYPINII SGQTEAKTIY AGVCHTQPEK GRKLVIDIGG
160 170 180 190 200
GSTEMIIGDD FTPLMAESRH MGCVSFATQF FTDGIISPEN FQRARQSAVN
210 220 230 240 250
KIEDLGLEYR KLGWQSVLGS SGTIKTVAQV IATNLDPNGT ITAERLNALI
260 270 280 290 300
EQTLQAKHFT ELNINGLNQD RVDVFVPGLA ILSAVFDVFH IQQMRYSDGA
310 320
LREGVIYSLE KNFQVADIRA STA
Length:323
Mass (Da):35,566
Last modified:November 1, 1995 - v1
Checksum:i5B7E9BBEFE780FB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22355.1.
PIRiC64087.
RefSeqiNP_438855.1. NC_000907.1.
WP_005694580.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22355; AAC22355; HI_0695.
GeneIDi950213.
KEGGihin:HI0695.
PATRICi20190011. VBIHaeInf48452_0727.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22355.1.
PIRiC64087.
RefSeqiNP_438855.1. NC_000907.1.
WP_005694580.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP44828.
SMRiP44828. Positions 16-321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0695.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22355; AAC22355; HI_0695.
GeneIDi950213.
KEGGihin:HI0695.
PATRICi20190011. VBIHaeInf48452_0727.

Phylogenomic databases

eggNOGiCOG0248.
KOiK01524.
OMAiVANGCIG.
OrthoDBiEOG6M6JN6.
PhylomeDBiP44828.

Family and domain databases

InterProiIPR022371. Exopolyphosphatase.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03706. exo_poly_only. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiPPX_HAEIN
AccessioniPrimary (citable) accession number: P44828
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 7, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Could be the product of a pseudogene. Compared with other ppx it lacks 200 residues at the C-terminal region.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.