Reviewed, UniProtKB/Swiss-Prot P44828 (PPX_HAEIN)

Names and origin

Protein names

Recommended name:
    Putative exopolyphosphatase
    EC=3.6.1.11
Alternative name(s):
    Metaphosphatase

Gene names

Name:	ppx
Ordered Locus Names:	HI0695

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Uncertain.

General annotation (Comments)

Function	Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate.
Catalytic activity	(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.
Cofactor	Magnesium By similarity.
Subcellular location	Cell membrane; Peripheral membrane protein Potential.
Sequence similarities	Belongs to the gppA/ppx family.
Caution	Could be the product of a pseudogene. Compared with other ppx it lacks 200 residues at the C-terminal region.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Ligand	Magnesium
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	exopolyphosphatase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	Putative exopolyphosphatase		PRO_0000194302

Sequences

	Sequence		Length	Mass (Da)
	P44828-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 5B7E9BBEFE780FB6	FASTA	323	35,566
	10 20 30 40 50 60 MNDSILEPKH RGNVREIAAI DLGSNSFHMI VARIVNGSIQ VLSRLKQKVK LAEGLDENAV 70 80 90 100 110 120 LNQEAITRGV NCLALFAERL QGFPMENVNV VGTYTLRRAV NNDEFLRQAA KVFPYPINII 130 140 150 160 170 180 SGQTEAKTIY AGVCHTQPEK GRKLVIDIGG GSTEMIIGDD FTPLMAESRH MGCVSFATQF 190 200 210 220 230 240 FTDGIISPEN FQRARQSAVN KIEDLGLEYR KLGWQSVLGS SGTIKTVAQV IATNLDPNGT 250 260 270 280 290 300 ITAERLNALI EQTLQAKHFT ELNINGLNQD RVDVFVPGLA ILSAVFDVFH IQQMRYSDGA 310 320 LREGVIYSLE KNFQVADIRA STA

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L42023 Genomic DNA. Translation: AAC22355.1.
PIR	C64087.
RefSeq	NP_438855.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	950213.
GenomeReviews	Gene locus HI0695 in contig L42023_GR.
KEGG	hin:HI0695.
NMPDR	fig|71421.1.peg.665.
TIGR	HI0695.
Phylogenomic databases
HOGENOM	P44828.
OMA	P44828. FNRRALP.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0695-MON.
BRENDA	3.6.1.11. 109.
Family and domain databases
InterPro	IPR003695. Ppx_GppA. [Graphical view]
Pfam	PF02541. Ppx-GppA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPX_HAEIN

Accession

Primary (citable) accession number: P44828

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)