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P44822

- ILVC_HAEIN

UniProt

P44822 - ILVC_HAEIN

Protein

Ketol-acid reductoisomerase

Gene

ilvC

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.
    (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei132 – 1321Sequence Analysis

    GO - Molecular functioni

    1. ketol-acid reductoisomerase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
    2. valine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00047; UER00056.
    UPA00049; UER00060.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ketol-acid reductoisomerase (EC:1.1.1.86)
    Alternative name(s):
    Acetohydroxy-acid isomeroreductase
    Alpha-keto-beta-hydroxylacyl reductoisomerase
    Gene namesi
    Name:ilvC
    Ordered Locus Names:HI_0682
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 492491Ketol-acid reductoisomerasePRO_0000151314Add
    BLAST

    Proteomic databases

    PRIDEiP44822.

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0682.

    Structurei

    3D structure databases

    ProteinModelPortaliP44822.
    SMRiP44822. Positions 3-490.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ketol-acid reductoisomerase family.Curated

    Phylogenomic databases

    eggNOGiCOG0059.
    KOiK00053.
    OMAiGYEKMVA.
    OrthoDBiEOG625K07.
    PhylomeDBiP44822.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPiMF_00435. IlvC.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013023. AcH_isomrdctse.
    IPR000506. AcH_isomrdctse_C.
    IPR013328. DH_multihelical.
    IPR013116. IlvN.
    IPR014359. KetolA_reductoisomerase_bac.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR21371. PTHR21371. 1 hit.
    PfamiPF01450. IlvC. 2 hits.
    PF07991. IlvN. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000116. IlvC_gammaproteo. 1 hit.
    SUPFAMiSSF48179. SSF48179. 2 hits.
    TIGRFAMsiTIGR00465. ilvC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P44822-1 [UniParc]FASTAAdd to Basket

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    MANYFNTLNL RQKLDQLGRC RFMDREEFAD EANFLKGKKI VIVGCGAQGL    50
    NQGLNMRDSG LDISYALRPE AIAEKRASFQ RATENGFKVG TYEELIPTAD 100
    LVVNLTPDKQ HSKVVADVMP LMKKDSAFGY SHGFNIVEVG EEIRKDITVV 150
    MVAPKCPGTE VREEYKRGFG VPTLIAVHPE NDPKGEGMAI AKAWAAATGG 200
    HKAGVLESSF VAEVKSDLMG EQTILCGMLQ AGSIVCYDKL VADGKDPAYA 250
    GKLIQYGWET ITEALKQGGI TLMMDRLSNS AKLRAFELAE QIKESLGFLY 300
    YKHMDDIISG HFSATMMADW ANGDKDLFAW REATGKTAFE NAPKYDGKIS 350
    EQEYFDNGVL MIAMVKAGVE LAFDAMVASG IYEESAYYES LHELPLIANT 400
    IARKRLYEMN VVISDTAEYG NYLFSNVATP ILAKEIIPNL QKGDLGEPTP 450
    AVEVDNITLR DVNDAIRNHP VELIGQELRG YMTDMKRIAV AG 492
    Length:492
    Mass (Da):54,239
    Last modified:January 23, 2007 - v2
    Checksum:i16D504256D7FF18E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22342.1.
    PIRiB64086.
    RefSeqiNP_438842.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22342; AAC22342; HI_0682.
    GeneIDi949478.
    KEGGihin:HI0682.
    PATRICi20189983. VBIHaeInf48452_0713.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22342.1 .
    PIRi B64086.
    RefSeqi NP_438842.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44822.
    SMRi P44822. Positions 3-490.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0682.

    Proteomic databases

    PRIDEi P44822.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22342 ; AAC22342 ; HI_0682 .
    GeneIDi 949478.
    KEGGi hin:HI0682.
    PATRICi 20189983. VBIHaeInf48452_0713.

    Phylogenomic databases

    eggNOGi COG0059.
    KOi K00053.
    OMAi GYEKMVA.
    OrthoDBi EOG625K07.
    PhylomeDBi P44822.

    Enzyme and pathway databases

    UniPathwayi UPA00047 ; UER00056 .
    UPA00049 ; UER00060 .

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPi MF_00435. IlvC.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013023. AcH_isomrdctse.
    IPR000506. AcH_isomrdctse_C.
    IPR013328. DH_multihelical.
    IPR013116. IlvN.
    IPR014359. KetolA_reductoisomerase_bac.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR21371. PTHR21371. 1 hit.
    Pfami PF01450. IlvC. 2 hits.
    PF07991. IlvN. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000116. IlvC_gammaproteo. 1 hit.
    SUPFAMi SSF48179. SSF48179. 2 hits.
    TIGRFAMsi TIGR00465. ilvC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiILVC_HAEIN
    AccessioniPrimary (citable) accession number: P44822
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3