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P44822

- ILVC_HAEIN

UniProt

P44822 - ILVC_HAEIN

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Protein
Ketol-acid reductoisomerase
Gene
ilvC, HI_0682
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.UniRule annotation
(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei132 – 1321 Reviewed prediction

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. ketol-acid reductoisomerase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
  2. valine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00047; UER00056.
UPA00049; UER00060.

Names & Taxonomyi

Protein namesi
Recommended name:
Ketol-acid reductoisomerase (EC:1.1.1.86)
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacyl reductoisomerase
Gene namesi
Name:ilvC
Ordered Locus Names:HI_0682
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 492491Ketol-acid reductoisomeraseUniRule annotation
PRO_0000151314Add
BLAST

Proteomic databases

PRIDEiP44822.

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0682.

Structurei

3D structure databases

ProteinModelPortaliP44822.
SMRiP44822. Positions 3-490.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0059.
KOiK00053.
OMAiGYEKMVA.
OrthoDBiEOG625K07.
PhylomeDBiP44822.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_00435. IlvC.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
IPR014359. KetolA_reductoisomerase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR21371. PTHR21371. 1 hit.
PfamiPF01450. IlvC. 2 hits.
PF07991. IlvN. 1 hit.
[Graphical view]
PIRSFiPIRSF000116. IlvC_gammaproteo. 1 hit.
SUPFAMiSSF48179. SSF48179. 2 hits.
TIGRFAMsiTIGR00465. ilvC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P44822-1 [UniParc]FASTAAdd to Basket

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MANYFNTLNL RQKLDQLGRC RFMDREEFAD EANFLKGKKI VIVGCGAQGL    50
NQGLNMRDSG LDISYALRPE AIAEKRASFQ RATENGFKVG TYEELIPTAD 100
LVVNLTPDKQ HSKVVADVMP LMKKDSAFGY SHGFNIVEVG EEIRKDITVV 150
MVAPKCPGTE VREEYKRGFG VPTLIAVHPE NDPKGEGMAI AKAWAAATGG 200
HKAGVLESSF VAEVKSDLMG EQTILCGMLQ AGSIVCYDKL VADGKDPAYA 250
GKLIQYGWET ITEALKQGGI TLMMDRLSNS AKLRAFELAE QIKESLGFLY 300
YKHMDDIISG HFSATMMADW ANGDKDLFAW REATGKTAFE NAPKYDGKIS 350
EQEYFDNGVL MIAMVKAGVE LAFDAMVASG IYEESAYYES LHELPLIANT 400
IARKRLYEMN VVISDTAEYG NYLFSNVATP ILAKEIIPNL QKGDLGEPTP 450
AVEVDNITLR DVNDAIRNHP VELIGQELRG YMTDMKRIAV AG 492
Length:492
Mass (Da):54,239
Last modified:January 23, 2007 - v2
Checksum:i16D504256D7FF18E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22342.1.
PIRiB64086.
RefSeqiNP_438842.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22342; AAC22342; HI_0682.
GeneIDi949478.
KEGGihin:HI0682.
PATRICi20189983. VBIHaeInf48452_0713.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22342.1 .
PIRi B64086.
RefSeqi NP_438842.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44822.
SMRi P44822. Positions 3-490.
ModBasei Search...

Protein-protein interaction databases

STRINGi 71421.HI0682.

Proteomic databases

PRIDEi P44822.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22342 ; AAC22342 ; HI_0682 .
GeneIDi 949478.
KEGGi hin:HI0682.
PATRICi 20189983. VBIHaeInf48452_0713.

Phylogenomic databases

eggNOGi COG0059.
KOi K00053.
OMAi GYEKMVA.
OrthoDBi EOG625K07.
PhylomeDBi P44822.

Enzyme and pathway databases

UniPathwayi UPA00047 ; UER00056 .
UPA00049 ; UER00060 .

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPi MF_00435. IlvC.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
IPR014359. KetolA_reductoisomerase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR21371. PTHR21371. 1 hit.
Pfami PF01450. IlvC. 2 hits.
PF07991. IlvN. 1 hit.
[Graphical view ]
PIRSFi PIRSF000116. IlvC_gammaproteo. 1 hit.
SUPFAMi SSF48179. SSF48179. 2 hits.
TIGRFAMsi TIGR00465. ilvC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiILVC_HAEIN
AccessioniPrimary (citable) accession number: P44822
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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