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P44822 (ILVC_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase

EC=1.1.1.86
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacyl reductoisomerase
Gene names
Name:ilvC
Ordered Locus Names:HI_0682
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP-Rule MF_00435

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP-Rule MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP-Rule MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP-Rule MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 492491Ketol-acid reductoisomerase HAMAP-Rule MF_00435
PRO_0000151314

Sites

Active site1321 Potential

Sequences

Sequence LengthMass (Da)Tools
P44822 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 16D504256D7FF18E

FASTA49254,239
        10         20         30         40         50         60 
MANYFNTLNL RQKLDQLGRC RFMDREEFAD EANFLKGKKI VIVGCGAQGL NQGLNMRDSG 

        70         80         90        100        110        120 
LDISYALRPE AIAEKRASFQ RATENGFKVG TYEELIPTAD LVVNLTPDKQ HSKVVADVMP 

       130        140        150        160        170        180 
LMKKDSAFGY SHGFNIVEVG EEIRKDITVV MVAPKCPGTE VREEYKRGFG VPTLIAVHPE 

       190        200        210        220        230        240 
NDPKGEGMAI AKAWAAATGG HKAGVLESSF VAEVKSDLMG EQTILCGMLQ AGSIVCYDKL 

       250        260        270        280        290        300 
VADGKDPAYA GKLIQYGWET ITEALKQGGI TLMMDRLSNS AKLRAFELAE QIKESLGFLY 

       310        320        330        340        350        360 
YKHMDDIISG HFSATMMADW ANGDKDLFAW REATGKTAFE NAPKYDGKIS EQEYFDNGVL 

       370        380        390        400        410        420 
MIAMVKAGVE LAFDAMVASG IYEESAYYES LHELPLIANT IARKRLYEMN VVISDTAEYG 

       430        440        450        460        470        480 
NYLFSNVATP ILAKEIIPNL QKGDLGEPTP AVEVDNITLR DVNDAIRNHP VELIGQELRG 

       490 
YMTDMKRIAV AG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22342.1.
PIRB64086.
RefSeqNP_438842.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44822.
SMRP44822. Positions 3-490.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0682.

Proteomic databases

PRIDEP44822.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22342; AAC22342; HI_0682.
GeneID949478.
KEGGhin:HI0682.
PATRIC20189983. VBIHaeInf48452_0713.

Phylogenomic databases

eggNOGCOG0059.
KOK00053.
OMAATLSYSH.
OrthoDBEOG625K07.
ProtClustDBPRK05225.

Enzyme and pathway databases

UniPathwayUPA00047; UER00056.
UPA00049; UER00060.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPMF_00435. IlvC.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
IPR014359. KetolA_reductoisomerase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR21371. PTHR21371. 1 hit.
PTHR21371:SF2. PTHR21371:SF2. 1 hit.
PfamPF01450. IlvC. 2 hits.
PF07991. IlvN. 1 hit.
[Graphical view]
PIRSFPIRSF000116. IlvC_gammaproteo. 1 hit.
SUPFAMSSF48179. SSF48179. 2 hits.
TIGRFAMsTIGR00465. ilvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameILVC_HAEIN
AccessionPrimary (citable) accession number: P44822
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names