P44814 (DTD_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
D-tyrosyl-tRNA(Tyr) deacylase
EC=3.1.-.-

Gene names

Name:	dtd
Ordered Locus Names:	HI_0670

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	144 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine By similarity. HAMAP-Rule MF_00518
Subunit structure	Homodimer.
Subcellular location	Cytoplasm Probable HAMAP-Rule MF_00518.
Sequence similarities	Belongs to the DTD family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	D-amino acid catabolic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	hydrolase activity, acting on ester bonds Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 144

144

D-tyrosyl-tRNA(Tyr) deacylase HAMAP-Rule MF_00518

PRO_0000164546

Sites

Active site

80

1

Nucleophile

Secondary structure

1

.

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.

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144

Helix Strand Turn

Details...

Beta strand

2 – 15

14

Beta strand

18 – 32

15

Helix

39 – 51

13

Beta strand

62 – 64

3

Turn

66 – 70

5

Beta strand

72 – 77

6

Helix

79 – 82

4

Helix

99 – 114

16

Beta strand

119 – 121

3

Beta strand

129 – 143

15

Sequences

	Sequence		Length	Mass (Da)
	P44814 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: D8F84702EF5A3CBB	FASTA	144	15,862
	10 20 30 40 50 60 MIALIQRVSQ AKVDVKGETI GKIGKGLLVL LGVEKEDNRE KADKLAEKVL NYRIFSDEND 70 80 90 100 110 120 KMNLNVQQAQ GELLIVSQFT LAADTQKGLR PSFSKGASPA LANELYEYFI QKCAEKLPVS 130 140 TGQFAADMQV SLTNDGPVTF WLNV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[2]	"A catalytic mechanism for D-Tyr-tRNATyr deacylase based on the crystal structure of Hemophilus influenzae HI0670." Lim K., Tempczyk A., Bonander N., Toedt J., Howard A., Eisenstein E., Herzberg O. J. Biol. Chem. 278:13496-13502(2003) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.64 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L42023 Genomic DNA. Translation: AAC22330.1.

PIR

E64156.

RefSeq

NP_438830.1. NC_000907.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1J7G	X-ray	1.64	A	1-144	[»]

ProteinModelPortal

P44814.

SMR

P44814. Positions 1-144.

ModBase

Search...

Protein-protein interaction databases

STRING

71421.HI0670.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAC22330; AAC22330; HI_0670.

GeneID

949713.

KEGG

hin:HI0670.

PATRIC

20189957. VBIHaeInf48452_0700.

Phylogenomic databases

eggNOG

COG1490.

KO

K07560.

OMA

DGPVTIW.

ProtClustDB

PRK05273.

Family and domain databases

Gene3D

3.50.80.10. 1 hit.

HAMAP

MF_00518. Tyr_Deacylase_Dtd.

InterPro

IPR023509. DTD-like_dom.
IPR003732. DTyrtRNA_deacyls.
[Graphical view]

PANTHER

PTHR10472. PTHR10472. 1 hit.

Pfam

PF02580. Tyr_Deacylase. 1 hit.
[Graphical view]

SUPFAM

SSF69500. DTyrtRNA_deacyls. 1 hit.

TIGRFAMs

TIGR00256. TIGR00256. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

P44814.

Entry information

Entry name

DTD_HAEIN

Accession

Primary (citable) accession number: P44814

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program