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P44814

- DTD_HAEIN

UniProt

P44814 - DTD_HAEIN

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Protein

D-aminoacyl-tRNA deacylase

Gene

dtd

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.UniRule annotation

Catalytic activityi

A D-aminoacyl-tRNA + H2O = a D-amino acid + tRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei80 – 801NucleophileUniRule annotation

GO - Molecular functioni

  1. hydrolase activity, acting on ester bonds Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-amino acid catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
D-aminoacyl-tRNA deacylaseUniRule annotation (EC:3.1.1.96UniRule annotation)
Alternative name(s):
D-tyrosyl-tRNA(Tyr) deacylase
Gene namesi
Name:dtdUniRule annotation
Ordered Locus Names:HI_0670
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Cytoplasm CuratedUniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 144144D-aminoacyl-tRNA deacylasePRO_0000164546Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi71421.HI0670.

Structurei

Secondary structure

1
144
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 1514
Beta strandi18 – 3215
Helixi39 – 5113
Beta strandi62 – 643
Turni66 – 705
Beta strandi72 – 776
Helixi79 – 824
Helixi99 – 11416
Beta strandi119 – 1213
Beta strandi129 – 14315

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1J7GX-ray1.64A1-144[»]
ProteinModelPortaliP44814.
SMRiP44814. Positions 1-144.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP44814.

Family & Domainsi

Sequence similaritiesi

Belongs to the DTD family.CuratedUniRule annotation

Phylogenomic databases

eggNOGiCOG1490.
KOiK07560.
OMAiGDENDKM.
OrthoDBiEOG6C2WM2.
PhylomeDBiP44814.

Family and domain databases

Gene3Di3.50.80.10. 1 hit.
HAMAPiMF_00518. Deacylase_Dtd.
InterProiIPR023509. DTD-like_dom.
IPR003732. DTyrtRNA_deacyls.
[Graphical view]
PANTHERiPTHR10472. PTHR10472. 1 hit.
PfamiPF02580. Tyr_Deacylase. 1 hit.
[Graphical view]
SUPFAMiSSF69500. SSF69500. 1 hit.
TIGRFAMsiTIGR00256. TIGR00256. 1 hit.

Sequencei

Sequence statusi: Complete.

P44814-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIALIQRVSQ AKVDVKGETI GKIGKGLLVL LGVEKEDNRE KADKLAEKVL
60 70 80 90 100
NYRIFSDEND KMNLNVQQAQ GELLIVSQFT LAADTQKGLR PSFSKGASPA
110 120 130 140
LANELYEYFI QKCAEKLPVS TGQFAADMQV SLTNDGPVTF WLNV
Length:144
Mass (Da):15,862
Last modified:November 1, 1995 - v1
Checksum:iD8F84702EF5A3CBB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22330.1.
PIRiE64156.
RefSeqiNP_438830.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22330; AAC22330; HI_0670.
GeneIDi949713.
KEGGihin:HI0670.
PATRICi20189957. VBIHaeInf48452_0700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22330.1 .
PIRi E64156.
RefSeqi NP_438830.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1J7G X-ray 1.64 A 1-144 [» ]
ProteinModelPortali P44814.
SMRi P44814. Positions 1-144.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0670.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22330 ; AAC22330 ; HI_0670 .
GeneIDi 949713.
KEGGi hin:HI0670.
PATRICi 20189957. VBIHaeInf48452_0700.

Phylogenomic databases

eggNOGi COG1490.
KOi K07560.
OMAi GDENDKM.
OrthoDBi EOG6C2WM2.
PhylomeDBi P44814.

Miscellaneous databases

EvolutionaryTracei P44814.

Family and domain databases

Gene3Di 3.50.80.10. 1 hit.
HAMAPi MF_00518. Deacylase_Dtd.
InterProi IPR023509. DTD-like_dom.
IPR003732. DTyrtRNA_deacyls.
[Graphical view ]
PANTHERi PTHR10472. PTHR10472. 1 hit.
Pfami PF02580. Tyr_Deacylase. 1 hit.
[Graphical view ]
SUPFAMi SSF69500. SSF69500. 1 hit.
TIGRFAMsi TIGR00256. TIGR00256. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. "A catalytic mechanism for D-Tyr-tRNATyr deacylase based on the crystal structure of Hemophilus influenzae HI0670."
    Lim K., Tempczyk A., Bonander N., Toedt J., Howard A., Eisenstein E., Herzberg O.
    J. Biol. Chem. 278:13496-13502(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.64 ANGSTROMS).

Entry informationi

Entry nameiDTD_HAEIN
AccessioniPrimary (citable) accession number: P44814
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3