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P44814

- DTD_HAEIN

UniProt

P44814 - DTD_HAEIN

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Protein
D-tyrosyl-tRNA(Tyr) deacylase
Gene
dtd, HI_0670
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei80 – 801Nucleophile

GO - Molecular functioni

  1. hydrolase activity, acting on ester bonds Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. D-amino acid catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
D-tyrosyl-tRNA(Tyr) deacylase (EC:3.1.-.-)
Gene namesi
Name:dtd
Ordered Locus Names:HI_0670
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Cytoplasm Inferred UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 144144D-tyrosyl-tRNA(Tyr) deacylaseUniRule annotation
PRO_0000164546Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi71421.HI0670.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 1514
Beta strandi18 – 3215
Helixi39 – 5113
Beta strandi62 – 643
Turni66 – 705
Beta strandi72 – 776
Helixi79 – 824
Helixi99 – 11416
Beta strandi119 – 1213
Beta strandi129 – 14315

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1J7GX-ray1.64A1-144[»]
ProteinModelPortaliP44814.
SMRiP44814. Positions 1-144.

Miscellaneous databases

EvolutionaryTraceiP44814.

Family & Domainsi

Sequence similaritiesi

Belongs to the DTD family.

Phylogenomic databases

eggNOGiCOG1490.
KOiK07560.
OMAiGDENDKM.
OrthoDBiEOG6C2WM2.
PhylomeDBiP44814.

Family and domain databases

Gene3Di3.50.80.10. 1 hit.
HAMAPiMF_00518. Tyr_Deacylase_Dtd.
InterProiIPR023509. DTD-like_dom.
IPR003732. DTyrtRNA_deacyls.
[Graphical view]
PANTHERiPTHR10472. PTHR10472. 1 hit.
PfamiPF02580. Tyr_Deacylase. 1 hit.
[Graphical view]
SUPFAMiSSF69500. SSF69500. 1 hit.
TIGRFAMsiTIGR00256. TIGR00256. 1 hit.

Sequencei

Sequence statusi: Complete.

P44814-1 [UniParc]FASTAAdd to Basket

« Hide

MIALIQRVSQ AKVDVKGETI GKIGKGLLVL LGVEKEDNRE KADKLAEKVL    50
NYRIFSDEND KMNLNVQQAQ GELLIVSQFT LAADTQKGLR PSFSKGASPA 100
LANELYEYFI QKCAEKLPVS TGQFAADMQV SLTNDGPVTF WLNV 144
Length:144
Mass (Da):15,862
Last modified:November 1, 1995 - v1
Checksum:iD8F84702EF5A3CBB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22330.1.
PIRiE64156.
RefSeqiNP_438830.1. NC_000907.1.
WP_005694618.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22330; AAC22330; HI_0670.
GeneIDi949713.
KEGGihin:HI0670.
PATRICi20189957. VBIHaeInf48452_0700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22330.1 .
PIRi E64156.
RefSeqi NP_438830.1. NC_000907.1.
WP_005694618.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1J7G X-ray 1.64 A 1-144 [» ]
ProteinModelPortali P44814.
SMRi P44814. Positions 1-144.
ModBasei Search...

Protein-protein interaction databases

STRINGi 71421.HI0670.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22330 ; AAC22330 ; HI_0670 .
GeneIDi 949713.
KEGGi hin:HI0670.
PATRICi 20189957. VBIHaeInf48452_0700.

Phylogenomic databases

eggNOGi COG1490.
KOi K07560.
OMAi GDENDKM.
OrthoDBi EOG6C2WM2.
PhylomeDBi P44814.

Miscellaneous databases

EvolutionaryTracei P44814.

Family and domain databases

Gene3Di 3.50.80.10. 1 hit.
HAMAPi MF_00518. Tyr_Deacylase_Dtd.
InterProi IPR023509. DTD-like_dom.
IPR003732. DTyrtRNA_deacyls.
[Graphical view ]
PANTHERi PTHR10472. PTHR10472. 1 hit.
Pfami PF02580. Tyr_Deacylase. 1 hit.
[Graphical view ]
SUPFAMi SSF69500. SSF69500. 1 hit.
TIGRFAMsi TIGR00256. TIGR00256. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. "A catalytic mechanism for D-Tyr-tRNATyr deacylase based on the crystal structure of Hemophilus influenzae HI0670."
    Lim K., Tempczyk A., Bonander N., Toedt J., Howard A., Eisenstein E., Herzberg O.
    J. Biol. Chem. 278:13496-13502(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.64 ANGSTROMS).

Entry informationi

Entry nameiDTD_HAEIN
AccessioniPrimary (citable) accession number: P44814
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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