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P44814

- DTD_HAEIN

UniProt

P44814 - DTD_HAEIN

Protein

D-tyrosyl-tRNA(Tyr) deacylase

Gene

dtd

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei80 – 801Nucleophile

    GO - Molecular functioni

    1. hydrolase activity, acting on ester bonds Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-amino acid catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D-tyrosyl-tRNA(Tyr) deacylase (EC:3.1.-.-)
    Gene namesi
    Name:dtd
    Ordered Locus Names:HI_0670
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 144144D-tyrosyl-tRNA(Tyr) deacylasePRO_0000164546Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    STRINGi71421.HI0670.

    Structurei

    Secondary structure

    1
    144
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 1514
    Beta strandi18 – 3215
    Helixi39 – 5113
    Beta strandi62 – 643
    Turni66 – 705
    Beta strandi72 – 776
    Helixi79 – 824
    Helixi99 – 11416
    Beta strandi119 – 1213
    Beta strandi129 – 14315

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1J7GX-ray1.64A1-144[»]
    ProteinModelPortaliP44814.
    SMRiP44814. Positions 1-144.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP44814.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DTD family.Curated

    Phylogenomic databases

    eggNOGiCOG1490.
    KOiK07560.
    OMAiGDENDKM.
    OrthoDBiEOG6C2WM2.
    PhylomeDBiP44814.

    Family and domain databases

    Gene3Di3.50.80.10. 1 hit.
    HAMAPiMF_00518. Tyr_Deacylase_Dtd.
    InterProiIPR023509. DTD-like_dom.
    IPR003732. DTyrtRNA_deacyls.
    [Graphical view]
    PANTHERiPTHR10472. PTHR10472. 1 hit.
    PfamiPF02580. Tyr_Deacylase. 1 hit.
    [Graphical view]
    SUPFAMiSSF69500. SSF69500. 1 hit.
    TIGRFAMsiTIGR00256. TIGR00256. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P44814-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIALIQRVSQ AKVDVKGETI GKIGKGLLVL LGVEKEDNRE KADKLAEKVL    50
    NYRIFSDEND KMNLNVQQAQ GELLIVSQFT LAADTQKGLR PSFSKGASPA 100
    LANELYEYFI QKCAEKLPVS TGQFAADMQV SLTNDGPVTF WLNV 144
    Length:144
    Mass (Da):15,862
    Last modified:November 1, 1995 - v1
    Checksum:iD8F84702EF5A3CBB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22330.1.
    PIRiE64156.
    RefSeqiNP_438830.1. NC_000907.1.
    WP_005694618.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22330; AAC22330; HI_0670.
    GeneIDi949713.
    KEGGihin:HI0670.
    PATRICi20189957. VBIHaeInf48452_0700.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22330.1 .
    PIRi E64156.
    RefSeqi NP_438830.1. NC_000907.1.
    WP_005694618.1. NC_000907.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1J7G X-ray 1.64 A 1-144 [» ]
    ProteinModelPortali P44814.
    SMRi P44814. Positions 1-144.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0670.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22330 ; AAC22330 ; HI_0670 .
    GeneIDi 949713.
    KEGGi hin:HI0670.
    PATRICi 20189957. VBIHaeInf48452_0700.

    Phylogenomic databases

    eggNOGi COG1490.
    KOi K07560.
    OMAi GDENDKM.
    OrthoDBi EOG6C2WM2.
    PhylomeDBi P44814.

    Miscellaneous databases

    EvolutionaryTracei P44814.

    Family and domain databases

    Gene3Di 3.50.80.10. 1 hit.
    HAMAPi MF_00518. Tyr_Deacylase_Dtd.
    InterProi IPR023509. DTD-like_dom.
    IPR003732. DTyrtRNA_deacyls.
    [Graphical view ]
    PANTHERi PTHR10472. PTHR10472. 1 hit.
    Pfami PF02580. Tyr_Deacylase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69500. SSF69500. 1 hit.
    TIGRFAMsi TIGR00256. TIGR00256. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
    2. "A catalytic mechanism for D-Tyr-tRNATyr deacylase based on the crystal structure of Hemophilus influenzae HI0670."
      Lim K., Tempczyk A., Bonander N., Toedt J., Howard A., Eisenstein E., Herzberg O.
      J. Biol. Chem. 278:13496-13502(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.64 ANGSTROMS).

    Entry informationi

    Entry nameiDTD_HAEIN
    AccessioniPrimary (citable) accession number: P44814
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3