Skip Header

Contribute Send feedback
Read comments (?) or add your own

P44798 (TORZ_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Trimethylamine-N-oxide reductase
Short name=TMAO reductase
Short name=Trimethylamine oxidase
EC=1.7.2.3
Gene names
Name:torZ
Synonyms:bisC
Ordered Locus Names:HI_0643
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length825 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions By similarity.

Catalytic activity

Trimethylamine + 2 (ferricytochrome c)-subunit + H2O = trimethylamine N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+.

Cofactor

Molybdenum (molybdopterin) By similarity.

Subcellular location

Periplasm By similarity.

Post-translational modification

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Sequence similarities

Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

Caution

Was originally (Ref.1) assigned to be a biotin sulfoxide reductase hence the original gene designation of bisC.

Ontologies

Keywords
   Cellular componentPeriplasm
   DomainSignal
   LigandMolybdenum
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentperiplasmic space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionelectron carrier activity

Inferred from electronic annotation. Source: InterPro

molybdenum ion binding

Inferred from electronic annotation. Source: InterPro

trimethylamine-N-oxide reductase (cytochrome c) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4040Tat-type signal Potential
Chain41 – 825785Trimethylamine-N-oxide reductase
PRO_0000019166

Sequences

Sequence LengthMass (Da)Tools
P44798 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 4254287D42B45E5B

FASTA82591,053
        10         20         30         40         50         60 
MKKNNVNEQR RDFLKKTSLG VAGSALSGGM VGVVSKSAVA KEAEMKTVVT AAHWGSIGVV 

        70         80         90        100        110        120 
VQDGKVVKSG PAIEPAVPNE LQTVVADQLY SERRVKCPMV RKGFLANPGK SDTTMRGRDE 

       130        140        150        160        170        180 
WVRVSWDEAL DLVHNQLKRV RDEHGSTGIF AGSYGWFSCG SLHASRTLLQ RYMNATGGFV 

       190        200        210        220        230        240 
GHKGDYSTGA AQVIMPHVLG TIEVYEQQTS WESILESSDI IVLWSANPLT TMRIAWMSTD 

       250        260        270        280        290        300 
QKGIEYFKKF QASGKRIICI DPQKSETCQM LNAEWIPVNT ATDVPLMLGI AHTLVEQGKH 

       310        320        330        340        350        360 
DKDFLKKYTS GYAKFEEYLL GKTDGQPKTA EWAAKICGVP AETIKQLAAD FASKRTMLMG 

       370        380        390        400        410        420 
GWGMQRQRHG EQTHWMLVTL ASMLGQIGLP GGGFGLSYHY SNGGVPTATG GIIGSITASP 

       430        440        450        460        470        480 
SGKAGAKTWL DDTSKSAFPL ARIADVLLHP GKKIQYNGTE ITYPDIKAVY WAGGNPFVHH 

       490        500        510        520        530        540 
QDTNTLVKAF QKPDVVIVNE VNWTPTARMA DIVLPATTSY ERNDLTMAGD YSMMSVYPMK 

       550        560        570        580        590        600 
QVVPPQFEAK NDYDIFVELA KRAGVEEQYT EGKTEMEWLE EFYNAAFSAA RANRVAMPRF 

       610        620        630        640        650        660 
DKFWAENKPL SFEAGEAAKK WVRYGEFRED PLLNPLGTPS GKIEIFSDVV EKMNYNDCKG 

       670        680        690        700        710        720 
HPSWMEPEEF AGNVTEEYPL ALVTPHPYYR LHSQLAHTSL RQKYAVNDRE PVMIHPEDAA 

       730        740        750        760        770        780 
ARGIKDGDIV RIHSKRGQVL AGAAVTENII KGTVALHEGA WYDPMYLGES EKPLCKNGCA 

       790        800        810        820 
NVLTRDEGTS KLAQGNSPNT CIVQIEKFIG VAPEVTVFKQ PKQVA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L42023 Genomic DNA. Translation: AAC22303.1.
PIRH64083.
RefSeqNP_438803.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44798.
SMRP44798. Positions 46-823.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID950790.
GenomeReviewsGene locus HI_0643 in contig L42023_GR.
KEGGhin:HI0643.
NMPDRfig|71421.1.peg.613.
PATRIC20189901. VBIHaeInf48452_0672.
TIGRHI_0643.

Phylogenomic databases

HOGENOMHBG304064.
OMAYVRYADF.
ProtClustDBCLSK892376.

Enzyme and pathway databases

BioCycHINF71421:HI_0643-MONOMER.

Family and domain databases

InterProIPR009010. Asp_de-COase-like_fold.
IPR006658. BisC.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR006311. TAT_signal.
[Graphical view]
Gene3DG3DSA:2.40.40.20. Asp_decarboxylase-like_fold. 1 hit.
KOK07812.
PfamPF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
[Graphical view]
SUPFAMSSF50692. Asp_decarb_fold. 1 hit.
TIGRFAMsTIGR00509. BisC_fam. 1 hit.
PROSITEPS00551. MOLYBDOPTERIN_PROK_1. False negative.
PS00490. MOLYBDOPTERIN_PROK_2. 1 hit.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTORZ_HAEIN
AccessionPrimary (citable) accession number: P44798
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 25, 2012
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents