P44791 (RSEA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sigma-E factor negative regulatory protein homolog

Gene names

Name:	rseA
Synonyms:	mclA
Ordered Locus Names:	HI_0629

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	195 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Negative regulator of RpoE By similarity.
Subcellular location	Cell membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the RseA family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to stress Inferred from electronic annotation. Source: InterPro
Cellular_component	inner membrane complex Inferred from electronic annotation. Source: InterPro integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sigma factor antagonist activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 195	195	Sigma-E factor negative regulatory protein homolog		PRO_0000097482
Regions
	Transmembrane	95 – 117	23	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P44791 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 9BA4C6AA8F91CA0F	FASTA	195	21,733
	10 20 30 40 50 60 MQKEQLSAYM DGEQVETDLI DALLRDEELQ ASWHSFHTVR SVMRKESAVF LGADFTAKMA 70 80 90 100 110 120 DLIELEDVKK VDVIAVSQPE PEDAHNSVFM QKLKAFFAPM TQVAVAAGVC LVAVLGVQSF 130 140 150 160 170 180 NNKNDASNLP ETPVLQTLPF NNAVQEVSYN APSKDTLTSD QLEKKSRRIG AMLQNYELQR 190 RMHSDALDVS SSQVR

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC22289.1.
PIR	G64082.
RefSeq	NP_438789.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P44791.
ModBase	Search...
Protein-protein interaction databases
STRING	71421.HI0629.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC22289; AAC22289; HI_0629.
GeneID	949684.
KEGG	hin:HI0629.
PATRIC	20189853. VBIHaeInf48452_0655.
Phylogenomic databases
eggNOG	COG3073.
KO	K03597.
OMA	QNQSYTN.
ProtClustDB	CLSK870615.
Family and domain databases
InterPro	IPR005573. Anti-sigma_E_RseA_C. IPR005572. Anti-sigma_E_RseA_N. IPR026279. RseA. [Graphical view]
Pfam	PF03873. RseA_C. 1 hit. PF03872. RseA_N. 1 hit. [Graphical view]
PIRSF	PIRSF016938. RseA. 1 hit.
SUPFAM	SSF89069. Anti-sigma_E_RseA_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RSEA_HAEIN

Accession

Primary (citable) accession number: P44791

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program