P44785 (METN_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Methionine import ATP-binding protein MetN
EC=3.6.3.-

Gene names

Name:	metN
Ordered Locus Names:	HI_0621

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system By similarity.
Subunit structure	The complex is composed of two ATP-binding proteins (MetN), two transmembrane proteins (MetI) and a solute-binding protein (MetQ) Potential.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family. [View classification] Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Amino-acid transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	Gram-negative-bacterium-type cell wall Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro D-methionine transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	Methionine import ATP-binding protein MetN		PRO_0000092509
Regions
	Domain	2 – 241	240	ABC transporter
	Nucleotide binding	38 – 45	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P44785 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 7457118E8BEB79C2	FASTA	345	37,880
	10 20 30 40 50 60 MIKLNNIXKI FELPXKKLTA LDNVSLNIEK GQICGVIGAS GAGKSTLIRC VNLLEKPTSG 70 80 90 100 110 120 SVIVDGVELT KLSDRELVLA RRQIGMIFQH FNLLSSRTVF ENVALPLELE SESKAKIQEK 130 140 150 160 170 180 ITALLDLVGL SEKRDAYPSN LSGGQKQRVA IARALASDPK VLLCDEATSA LDPATTQSIL 190 200 210 220 230 240 KLLKEINRTL GITILLITHE MEVVKQICDQ VAVIDQGRLV EQGTVGEIFA NPKTELAQEF 250 260 270 280 290 300 IRSTFHISLP DEYLENLTDT PKHSKAYPII KFEFTGRSVD APLLSQASKK FGVELSILTS 310 320 330 340 QIDYAGGVKF GYTIAEVEGD EDAITQTKVY LMENNVRVEV LGYVQ

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC22280.1.
PIR	C64082.
RefSeq	NP_438780.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P44785.
ModBase	Search...
Protein-protein interaction databases
STRING	71421.HI0621.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC22280; AAC22280; HI_0621.
GeneID	950557.
KEGG	hin:HI0621.
PATRIC	20189827. VBIHaeInf48452_0646.
Phylogenomic databases
eggNOG	COG1135.
KO	K02071.
OMA	GASGDVH.
ProtClustDB	PRK11153.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR026253. ABC_MetN. IPR012692. ABC_MetN_proteobac. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017908. ABC_transprt_methionine_MetN_C. IPR018449. NIL_domain. [Graphical view]
PANTHER	PTHR24220:SF186. PTHR24220:SF186. 1 hit.
Pfam	PF00005. ABC_tran. 1 hit. PF09383. NIL. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. SM00930. NIL. 1 hit. [Graphical view]
TIGRFAMs	TIGR02314. ABC_MetN. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51264. METN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

METN_HAEIN

Accession

Primary (citable) accession number: P44785

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program