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Protein

Rhomboid protease GlpG

Gene

glpG

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Rhomboid-type serine protease that catalyzes intramembrane proteolysis.By similarity

Catalytic activityi

Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei116Nucleophile1 Publication1
Active sitei1691 Publication1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.105. 2529.

Protein family/group databases

MEROPSiS54.024.

Names & Taxonomyi

Protein namesi
Recommended name:
Rhomboid protease GlpG (EC:3.4.21.105)
Alternative name(s):
Intramembrane serine protease
Gene namesi
Name:glpG
Ordered Locus Names:HI_0618
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini32 – 57PeriplasmicSequence analysisAdd BLAST26
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 82CytoplasmicSequence analysis4
Transmembranei83 – 103Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini104 – 107PeriplasmicSequence analysis4
Transmembranei108 – 128Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini129 – 141CytoplasmicSequence analysisAdd BLAST13
Transmembranei142 – 162Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini163PeriplasmicSequence analysis1
Transmembranei164 – 184Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini185 – 192CytoplasmicSequence analysis8

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000875161 – 192Rhomboid protease GlpGAdd BLAST192

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-10098079,EBI-10098079

Protein-protein interaction databases

IntActiP44783. 1 interactor.
STRINGi71421.HI0618.

Structurei

Secondary structure

1192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 27Combined sources18
Helixi31 – 38Combined sources8
Helixi44 – 48Combined sources5
Helixi52 – 55Combined sources4
Helixi56 – 58Combined sources3
Helixi63 – 84Combined sources22
Helixi86 – 108Combined sources23
Helixi116 – 131Combined sources16
Turni144 – 148Combined sources5
Turni150 – 152Combined sources3
Helixi153 – 156Combined sources4
Helixi166 – 191Combined sources26

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NR9X-ray2.20A1-192[»]
3ODJX-ray2.84A1-192[»]
ProteinModelPortaliP44783.
SMRiP44783.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP44783.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S54 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EBW. Bacteria.
COG0705. LUCA.
KOiK02441.
OMAiPEGFFTM.
PhylomeDBiP44783.

Family and domain databases

Gene3Di1.20.1540.10. 1 hit.
InterProiIPR002610. Peptidase_S54_rhomboid.
IPR022764. Peptidase_S54_rhomboid_dom.
[Graphical view]
PANTHERiPTHR22936. PTHR22936. 1 hit.
PfamiPF01694. Rhomboid. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44783-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNFLAQQGK ITLILTALCV LIYLAQQLGF EDDIMYLMHY PAYEEQDSEV
60 70 80 90 100
WRYISHTLVH LSNLHILFNL SWFFIFGGMI ERTFGSVKLL MLYVVASAIT
110 120 130 140 150
GYVQNYVSGP AFFGLSGVVY AVLGYVFIRD KLNHHLFDLP EGFFTMLLVG
160 170 180 190
IALGFISPLF GVEMGNAAHI SGLIVGLIWG FIDSKLRKNS LE
Length:192
Mass (Da):21,657
Last modified:November 1, 1995 - v1
Checksum:iB76A7A658037217E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22277.1.
PIRiI64081.
RefSeqiNP_438776.1. NC_000907.1.
WP_005648561.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22277; AAC22277; HI_0618.
GeneIDi950685.
KEGGihin:HI0618.
PATRICi20189819. VBIHaeInf48452_0642.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22277.1.
PIRiI64081.
RefSeqiNP_438776.1. NC_000907.1.
WP_005648561.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NR9X-ray2.20A1-192[»]
3ODJX-ray2.84A1-192[»]
ProteinModelPortaliP44783.
SMRiP44783.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP44783. 1 interactor.
STRINGi71421.HI0618.

Protein family/group databases

MEROPSiS54.024.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22277; AAC22277; HI_0618.
GeneIDi950685.
KEGGihin:HI0618.
PATRICi20189819. VBIHaeInf48452_0642.

Phylogenomic databases

eggNOGiENOG4105EBW. Bacteria.
COG0705. LUCA.
KOiK02441.
OMAiPEGFFTM.
PhylomeDBiP44783.

Enzyme and pathway databases

BRENDAi3.4.21.105. 2529.

Miscellaneous databases

EvolutionaryTraceiP44783.

Family and domain databases

Gene3Di1.20.1540.10. 1 hit.
InterProiIPR002610. Peptidase_S54_rhomboid.
IPR022764. Peptidase_S54_rhomboid_dom.
[Graphical view]
PANTHERiPTHR22936. PTHR22936. 1 hit.
PfamiPF01694. Rhomboid. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLPG_HAEIN
AccessioniPrimary (citable) accession number: P44783
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.