ID   FUCI_HAEIN              Reviewed;         589 AA.
AC   P44779;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 2.
DT   13-SEP-2023, entry version 129.
DE   RecName: Full=L-fucose isomerase {ECO:0000255|HAMAP-Rule:MF_01254};
DE            EC=5.3.1.25 {ECO:0000255|HAMAP-Rule:MF_01254};
DE   AltName: Full=6-deoxy-L-galactose isomerase {ECO:0000255|HAMAP-Rule:MF_01254};
DE   AltName: Full=FucIase;
GN   Name=fucI {ECO:0000255|HAMAP-Rule:MF_01254};
GN   OrderedLocusNames=HI_0614;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Converts the aldose L-fucose into the corresponding ketose L-
CC       fuculose. {ECO:0000255|HAMAP-Rule:MF_01254}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-fucose = L-fuculose; Xref=Rhea:RHEA:17233, ChEBI:CHEBI:2181,
CC         ChEBI:CHEBI:17617; EC=5.3.1.25; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01254};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01254};
CC   -!- PATHWAY: Carbohydrate degradation; L-fucose degradation; L-lactaldehyde
CC       and glycerone phosphate from L-fucose: step 1/3. {ECO:0000255|HAMAP-
CC       Rule:MF_01254}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01254}.
CC   -!- SIMILARITY: Belongs to the L-fucose isomerase family.
CC       {ECO:0000255|HAMAP-Rule:MF_01254}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC22273.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; L42023; AAC22273.1; ALT_INIT; Genomic_DNA.
DR   PIR; F64081; F64081.
DR   RefSeq; NP_438772.2; NC_000907.1.
DR   AlphaFoldDB; P44779; -.
DR   SMR; P44779; -.
DR   STRING; 71421.HI_0614; -.
DR   EnsemblBacteria; AAC22273; AAC22273; HI_0614.
DR   KEGG; hin:HI_0614; -.
DR   PATRIC; fig|71421.8.peg.638; -.
DR   eggNOG; COG2407; Bacteria.
DR   HOGENOM; CLU_033326_1_0_6; -.
DR   OrthoDB; 9760430at2; -.
DR   PhylomeDB; P44779; -.
DR   BioCyc; HINF71421:G1GJ1-635-MONOMER; -.
DR   UniPathway; UPA00563; UER00624.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008790; F:arabinose isomerase activity; IBA:GO_Central.
DR   GO; GO:0008736; F:L-fucose isomerase activity; IBA:GO_Central.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0019571; P:D-arabinose catabolic process; IBA:GO_Central.
DR   GO; GO:0042355; P:L-fucose catabolic process; IBA:GO_Central.
DR   Gene3D; 3.40.50.1070; -; 1.
DR   Gene3D; 3.20.14.10; L-fucose/L-arabinose isomerase, C-terminal; 1.
DR   HAMAP; MF_01254; Fucose_iso; 1.
DR   InterPro; IPR004216; Fuc/Ara_isomerase_C.
DR   InterPro; IPR038393; Fuc_iso_dom3_sf.
DR   InterPro; IPR015888; Fuc_isomerase_C.
DR   InterPro; IPR038391; Fucose_iso_dom1_sf.
DR   InterPro; IPR012888; Fucose_iso_N1.
DR   InterPro; IPR005763; Fucose_isomerase.
DR   InterPro; IPR038392; Fucose_isomerase_dom2_sf.
DR   InterPro; IPR009015; Fucose_isomerase_N/cen_sf.
DR   InterPro; IPR012889; Fucose_isomerase_N2.
DR   NCBIfam; TIGR01089; fucI; 1.
DR   PANTHER; PTHR37840; L-FUCOSE ISOMERASE; 1.
DR   PANTHER; PTHR37840:SF1; L-FUCOSE ISOMERASE; 1.
DR   Pfam; PF02952; Fucose_iso_C; 1.
DR   Pfam; PF07881; Fucose_iso_N1; 1.
DR   Pfam; PF07882; Fucose_iso_N2; 1.
DR   SUPFAM; SSF50443; FucI/AraA C-terminal domain-like; 1.
DR   SUPFAM; SSF53743; FucI/AraA N-terminal and middle domains; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Fucose metabolism; Isomerase;
KW   Manganese; Metal-binding; Reference proteome.
FT   CHAIN           1..589
FT                   /note="L-fucose isomerase"
FT                   /id="PRO_0000204148"
FT   ACT_SITE        340
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01254"
FT   ACT_SITE        364
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01254"
FT   BINDING         340
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01254"
FT   BINDING         364
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01254"
FT   BINDING         527
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01254"
SQ   SEQUENCE   589 AA;  65401 MW;  F2E8FF1C65FFFC90 CRC64;
     MALATQSNRI KIGIRPTIDG RRMGVRESLE TQTIRMAQSV AQLLQTHIRH TDGTFVECVV
     ADSTIGGVAE AAACADKFKR ENVGLTITVT PCWCYGSETI DMDPHMPKAI WGFNGTERPG
     AVYLAAALAG HSQLGLPAFS IYGTEVQEAD DTNIPEDVKE KLLRFARAGL AVASIRGKSY
     LSIGSVSMGI AGSIVNQAFF QEYLGMRNEY VDMMEIKRRL DRKIYDQEEV DLALSWVKQY
     CKEGVDVNSL ENQRNAEERA ELWENVVKMT IITRDLMVGN PKLATLNYAE EALGHNAIAA
     GFQGQRHWTD HLPNGDFMEA MLNSTYDWNG VRPPYILATE NDSLNAIGML FGHQLTGKAQ
     IFADVRTYWS QDSVERVTGW RPESGFIHLI NSGSAALDGT GEHQDAQGNP TLKPAWDVTE
     EEAKRCLENT RWCPAVHEYF RGGGLSSQFL TKGGIPFTIH RINLIKGLGP VLQIAEGWSI
     DLPQDVHNKL NQRTNETWPT TWFVPRLTGK GAFTDVYSVM ANWGANHCVA THGHVGADLI
     TLASMLRIPV CMHNVSEKNI FRPSAWNGFG QDKEGQDYRA CQNFGPLYK
//