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Protein

L-fucose isomerase

Gene

fucI

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotation

Catalytic activityi

L-fucopyranose = L-fuculose.UniRule annotation

Cofactori

Mn2+UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei340 – 3401Proton acceptorUniRule annotation
Metal bindingi340 – 3401ManganeseUniRule annotation
Active sitei364 – 3641Proton acceptorUniRule annotation
Metal bindingi364 – 3641ManganeseUniRule annotation
Metal bindingi527 – 5271ManganeseUniRule annotation

GO - Molecular functioni

  1. L-fucose isomerase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-fucose catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Fucose metabolism

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00563; UER00624.

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)
Alternative name(s):
6-deoxy-L-galactose isomeraseUniRule annotation
FucIase
Gene namesi
Name:fucIUniRule annotation
Ordered Locus Names:HI_0614
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 589589L-fucose isomerasePRO_0000204148Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0614.

Structurei

3D structure databases

ProteinModelPortaliP44779.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-fucose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2407.
KOiK01818.
OMAiRTDPTWP.
OrthoDBiEOG6FJNCF.
PhylomeDBiP44779.

Family and domain databases

Gene3Di3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPiMF_01254. Fucose_iso.
InterProiIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamiPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsiTIGR01089. fucI. 1 hit.

Sequencei

Sequence statusi: Complete.

P44779-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALATQSNRI KIGIRPTIDG RRMGVRESLE TQTIRMAQSV AQLLQTHIRH
60 70 80 90 100
TDGTFVECVV ADSTIGGVAE AAACADKFKR ENVGLTITVT PCWCYGSETI
110 120 130 140 150
DMDPHMPKAI WGFNGTERPG AVYLAAALAG HSQLGLPAFS IYGTEVQEAD
160 170 180 190 200
DTNIPEDVKE KLLRFARAGL AVASIRGKSY LSIGSVSMGI AGSIVNQAFF
210 220 230 240 250
QEYLGMRNEY VDMMEIKRRL DRKIYDQEEV DLALSWVKQY CKEGVDVNSL
260 270 280 290 300
ENQRNAEERA ELWENVVKMT IITRDLMVGN PKLATLNYAE EALGHNAIAA
310 320 330 340 350
GFQGQRHWTD HLPNGDFMEA MLNSTYDWNG VRPPYILATE NDSLNAIGML
360 370 380 390 400
FGHQLTGKAQ IFADVRTYWS QDSVERVTGW RPESGFIHLI NSGSAALDGT
410 420 430 440 450
GEHQDAQGNP TLKPAWDVTE EEAKRCLENT RWCPAVHEYF RGGGLSSQFL
460 470 480 490 500
TKGGIPFTIH RINLIKGLGP VLQIAEGWSI DLPQDVHNKL NQRTNETWPT
510 520 530 540 550
TWFVPRLTGK GAFTDVYSVM ANWGANHCVA THGHVGADLI TLASMLRIPV
560 570 580
CMHNVSEKNI FRPSAWNGFG QDKEGQDYRA CQNFGPLYK
Length:589
Mass (Da):65,401
Last modified:January 4, 2005 - v2
Checksum:iF2E8FF1C65FFFC90
GO

Sequence cautioni

The sequence AAC22273.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22273.1. Different initiation.
PIRiF64081.
RefSeqiNP_438772.2. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22273; AAC22273; HI_0614.
GeneIDi950887.
KEGGihin:HI0614.
PATRICi20189811. VBIHaeInf48452_0638.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22273.1. Different initiation.
PIRiF64081.
RefSeqiNP_438772.2. NC_000907.1.

3D structure databases

ProteinModelPortaliP44779.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0614.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22273; AAC22273; HI_0614.
GeneIDi950887.
KEGGihin:HI0614.
PATRICi20189811. VBIHaeInf48452_0638.

Phylogenomic databases

eggNOGiCOG2407.
KOiK01818.
OMAiRTDPTWP.
OrthoDBiEOG6FJNCF.
PhylomeDBiP44779.

Enzyme and pathway databases

UniPathwayiUPA00563; UER00624.

Family and domain databases

Gene3Di3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPiMF_01254. Fucose_iso.
InterProiIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamiPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsiTIGR01089. fucI. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiFUCI_HAEIN
AccessioniPrimary (citable) accession number: P44779
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 4, 2005
Last modified: January 7, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.