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P44779

- FUCI_HAEIN

UniProt

P44779 - FUCI_HAEIN

Protein

L-fucose isomerase

Gene

fucI

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotation

    Catalytic activityi

    L-fucopyranose = L-fuculose.UniRule annotation

    Cofactori

    Manganese.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei340 – 3401Proton acceptorUniRule annotation
    Metal bindingi340 – 3401ManganeseUniRule annotation
    Active sitei364 – 3641Proton acceptorUniRule annotation
    Metal bindingi364 – 3641ManganeseUniRule annotation
    Metal bindingi527 – 5271ManganeseUniRule annotation

    GO - Molecular functioni

    1. L-fucose isomerase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-fucose catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism, Fucose metabolism

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00563; UER00624.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)
    Alternative name(s):
    6-deoxy-L-galactose isomeraseUniRule annotation
    FucIase
    Gene namesi
    Name:fucIUniRule annotation
    Ordered Locus Names:HI_0614
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 589589L-fucose isomerasePRO_0000204148Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0614.

    Structurei

    3D structure databases

    ProteinModelPortaliP44779.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the L-fucose isomerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2407.
    KOiK01818.
    OMAiKEGQDYR.
    OrthoDBiEOG6FJNCF.
    PhylomeDBiP44779.

    Family and domain databases

    Gene3Di3.20.14.10. 1 hit.
    3.40.275.10. 1 hit.
    3.40.50.1070. 1 hit.
    HAMAPiMF_01254. Fucose_iso.
    InterProiIPR004216. Fuc/Ara_isomerase_C.
    IPR015888. Fuc_isomerase_C.
    IPR012888. Fucose_iso_N1.
    IPR005763. Fucose_isomerase.
    IPR009015. Fucose_isomerase_N/cen.
    IPR012889. Fucose_isomerase_N2.
    [Graphical view]
    PfamiPF02952. Fucose_iso_C. 1 hit.
    PF07881. Fucose_iso_N1. 1 hit.
    PF07882. Fucose_iso_N2. 1 hit.
    [Graphical view]
    SUPFAMiSSF50443. SSF50443. 1 hit.
    SSF53743. SSF53743. 1 hit.
    TIGRFAMsiTIGR01089. fucI. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P44779-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALATQSNRI KIGIRPTIDG RRMGVRESLE TQTIRMAQSV AQLLQTHIRH    50
    TDGTFVECVV ADSTIGGVAE AAACADKFKR ENVGLTITVT PCWCYGSETI 100
    DMDPHMPKAI WGFNGTERPG AVYLAAALAG HSQLGLPAFS IYGTEVQEAD 150
    DTNIPEDVKE KLLRFARAGL AVASIRGKSY LSIGSVSMGI AGSIVNQAFF 200
    QEYLGMRNEY VDMMEIKRRL DRKIYDQEEV DLALSWVKQY CKEGVDVNSL 250
    ENQRNAEERA ELWENVVKMT IITRDLMVGN PKLATLNYAE EALGHNAIAA 300
    GFQGQRHWTD HLPNGDFMEA MLNSTYDWNG VRPPYILATE NDSLNAIGML 350
    FGHQLTGKAQ IFADVRTYWS QDSVERVTGW RPESGFIHLI NSGSAALDGT 400
    GEHQDAQGNP TLKPAWDVTE EEAKRCLENT RWCPAVHEYF RGGGLSSQFL 450
    TKGGIPFTIH RINLIKGLGP VLQIAEGWSI DLPQDVHNKL NQRTNETWPT 500
    TWFVPRLTGK GAFTDVYSVM ANWGANHCVA THGHVGADLI TLASMLRIPV 550
    CMHNVSEKNI FRPSAWNGFG QDKEGQDYRA CQNFGPLYK 589
    Length:589
    Mass (Da):65,401
    Last modified:January 4, 2005 - v2
    Checksum:iF2E8FF1C65FFFC90
    GO

    Sequence cautioni

    The sequence AAC22273.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22273.1. Different initiation.
    PIRiF64081.
    RefSeqiNP_438772.2. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22273; AAC22273; HI_0614.
    GeneIDi950887.
    KEGGihin:HI0614.
    PATRICi20189811. VBIHaeInf48452_0638.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22273.1 . Different initiation.
    PIRi F64081.
    RefSeqi NP_438772.2. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44779.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0614.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22273 ; AAC22273 ; HI_0614 .
    GeneIDi 950887.
    KEGGi hin:HI0614.
    PATRICi 20189811. VBIHaeInf48452_0638.

    Phylogenomic databases

    eggNOGi COG2407.
    KOi K01818.
    OMAi KEGQDYR.
    OrthoDBi EOG6FJNCF.
    PhylomeDBi P44779.

    Enzyme and pathway databases

    UniPathwayi UPA00563 ; UER00624 .

    Family and domain databases

    Gene3Di 3.20.14.10. 1 hit.
    3.40.275.10. 1 hit.
    3.40.50.1070. 1 hit.
    HAMAPi MF_01254. Fucose_iso.
    InterProi IPR004216. Fuc/Ara_isomerase_C.
    IPR015888. Fuc_isomerase_C.
    IPR012888. Fucose_iso_N1.
    IPR005763. Fucose_isomerase.
    IPR009015. Fucose_isomerase_N/cen.
    IPR012889. Fucose_isomerase_N2.
    [Graphical view ]
    Pfami PF02952. Fucose_iso_C. 1 hit.
    PF07881. Fucose_iso_N1. 1 hit.
    PF07882. Fucose_iso_N2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50443. SSF50443. 1 hit.
    SSF53743. SSF53743. 1 hit.
    TIGRFAMsi TIGR01089. fucI. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiFUCI_HAEIN
    AccessioniPrimary (citable) accession number: P44779
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3