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P44779 (FUCI_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
L-fucose isomerase

EC=5.3.1.25
Alternative name(s):
6-deoxy-L-galactose isomerase
FucIase
Gene names
Name:fucI
Ordered Locus Names:HI_0614
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length589 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts the aldose L-fucose into the corresponding ketose L-fuculose By similarity. HAMAP-Rule MF_01254

Catalytic activity

L-fucopyranose = L-fuculose. HAMAP-Rule MF_01254

Cofactor

Manganese By similarity. HAMAP-Rule MF_01254

Pathway

Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 1/3. HAMAP-Rule MF_01254

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01254.

Sequence similarities

Belongs to the L-fucose isomerase family.

Sequence caution

The sequence AAC22273.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Fucose metabolism
   Cellular componentCytoplasm
   LigandManganese
Metal-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processL-fucose catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionL-fucose isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

manganese ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 589589L-fucose isomerase HAMAP-Rule MF_01254
PRO_0000204148

Sites

Active site3401Proton acceptor By similarity
Active site3641Proton acceptor By similarity
Metal binding3401Manganese By similarity
Metal binding3641Manganese By similarity
Metal binding5271Manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
P44779 [UniParc].

Last modified January 4, 2005. Version 2.
Checksum: F2E8FF1C65FFFC90

FASTA58965,401
        10         20         30         40         50         60 
MALATQSNRI KIGIRPTIDG RRMGVRESLE TQTIRMAQSV AQLLQTHIRH TDGTFVECVV 

        70         80         90        100        110        120 
ADSTIGGVAE AAACADKFKR ENVGLTITVT PCWCYGSETI DMDPHMPKAI WGFNGTERPG 

       130        140        150        160        170        180 
AVYLAAALAG HSQLGLPAFS IYGTEVQEAD DTNIPEDVKE KLLRFARAGL AVASIRGKSY 

       190        200        210        220        230        240 
LSIGSVSMGI AGSIVNQAFF QEYLGMRNEY VDMMEIKRRL DRKIYDQEEV DLALSWVKQY 

       250        260        270        280        290        300 
CKEGVDVNSL ENQRNAEERA ELWENVVKMT IITRDLMVGN PKLATLNYAE EALGHNAIAA 

       310        320        330        340        350        360 
GFQGQRHWTD HLPNGDFMEA MLNSTYDWNG VRPPYILATE NDSLNAIGML FGHQLTGKAQ 

       370        380        390        400        410        420 
IFADVRTYWS QDSVERVTGW RPESGFIHLI NSGSAALDGT GEHQDAQGNP TLKPAWDVTE 

       430        440        450        460        470        480 
EEAKRCLENT RWCPAVHEYF RGGGLSSQFL TKGGIPFTIH RINLIKGLGP VLQIAEGWSI 

       490        500        510        520        530        540 
DLPQDVHNKL NQRTNETWPT TWFVPRLTGK GAFTDVYSVM ANWGANHCVA THGHVGADLI 

       550        560        570        580 
TLASMLRIPV CMHNVSEKNI FRPSAWNGFG QDKEGQDYRA CQNFGPLYK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22273.1. Different initiation.
PIRF64081.
RefSeqNP_438772.2. NC_000907.1.

3D structure databases

ProteinModelPortalP44779.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0614.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22273; AAC22273; HI_0614.
GeneID950887.
KEGGhin:HI0614.
PATRIC20189811. VBIHaeInf48452_0638.

Phylogenomic databases

eggNOGCOG2407.
KOK01818.
OMAKIGIRPT.
OrthoDBEOG6FJNCF.
ProtClustDBPRK10991.

Enzyme and pathway databases

UniPathwayUPA00563; UER00624.

Family and domain databases

Gene3D3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPMF_01254. Fucose_iso.
InterProIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsTIGR01089. fucI. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFUCI_HAEIN
AccessionPrimary (citable) accession number: P44779
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 4, 2005
Last modified: April 16, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names