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Protein

L-fuculose phosphate aldolase

Gene

fucA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde.UniRule annotation

Catalytic activityi

L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-fucose degradation

This protein is involved in step 3 of the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. L-fucose isomerase (fucI)
  2. L-fuculokinase (fucK)
  3. L-fuculose phosphate aldolase (fucA)
This subpathway is part of the pathway L-fucose degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose, the pathway L-fucose degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73Proton acceptorUniRule annotation1
Metal bindingi73ZincUniRule annotation1
Metal bindingi92ZincUniRule annotation1
Metal bindingi94ZincUniRule annotation1
Active sitei113Proton donorUniRule annotation1
Metal bindingi155ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processCarbohydrate metabolism, Fucose metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-632-MONOMER
UniPathwayiUPA00563; UER00626

Names & Taxonomyi

Protein namesi
Recommended name:
L-fuculose phosphate aldolaseUniRule annotation (EC:4.1.2.17UniRule annotation)
Alternative name(s):
L-fuculose-1-phosphate aldolaseUniRule annotation
Gene namesi
Name:fucAUniRule annotation
Ordered Locus Names:HI_0611
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001629281 – 216L-fuculose phosphate aldolaseAdd BLAST216

Proteomic databases

PRIDEiP44777

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi71421.HI0611

Structurei

3D structure databases

ProteinModelPortaliP44777
SMRiP44777
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldolase class II family. AraD/FucA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107W7X Bacteria
COG0235 LUCA
KOiK01628
OMAiLCEQYWR
PhylomeDBiP44777

Family and domain databases

Gene3Di3.40.225.10, 1 hit
HAMAPiMF_00987 FucA, 1 hit
InterProiView protein in InterPro
IPR001303 Aldolase_II/adducin_N
IPR036409 Aldolase_II/adducin_N_sf
IPR004782 FucA
PfamiView protein in Pfam
PF00596 Aldolase_II, 1 hit
SMARTiView protein in SMART
SM01007 Aldolase_II, 1 hit
SUPFAMiSSF53639 SSF53639, 1 hit
TIGRFAMsiTIGR01086 fucA, 1 hit

Sequencei

Sequence statusi: Complete.

P44777-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRAELSQKI IDTCLEMTKL GLNQGTAGNV SVRYKDGMLI TPTGMPYHLM
60 70 80 90 100
KTENIVYVDG NGKHEENKLP SSEWQFHLSV YHTRPEANAV VHNHSIHCAG
110 120 130 140 150
LSILEKPIPA IHYMVAVSGT DHIPCVPYAT FGSHKLASYV ATGIKESKAI
160 170 180 190 200
LLAHHGLITC GENLDKALWL AQEVEVLASW YLKLLSTGLE IPLLSKEQMQ
210
VVLGKFHTYG LRIEES
Length:216
Mass (Da):23,944
Last modified:November 1, 1995 - v1
Checksum:i4DBEEE21ED8EA6C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC22270.1
PIRiC64081
RefSeqiNP_438769.1, NC_000907.1
WP_005694545.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC22270; AAC22270; HI_0611
GeneIDi950000
KEGGihin:HI0611
PATRICifig|71421.8.peg.635

Similar proteinsi

Entry informationi

Entry nameiFUCA_HAEIN
AccessioniPrimary (citable) accession number: P44777
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health