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P44777

- FUCA_HAEIN

UniProt

P44777 - FUCA_HAEIN

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Protein

L-fuculose phosphate aldolase

Gene
fucA, HI_0611
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde By similarity.UniRule annotation

Catalytic activityi

L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit Reviewed prediction.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731Proton acceptor By similarity
Metal bindingi73 – 731Zinc By similarity
Metal bindingi92 – 921Zinc By similarity
Metal bindingi94 – 941Zinc By similarity
Active sitei113 – 1131Proton donor By similarity
Metal bindingi155 – 1551Zinc By similarity

GO - Molecular functioni

  1. L-fuculose-phosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. fucose catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbohydrate metabolism, Fucose metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00563; UER00626.

Names & Taxonomyi

Protein namesi
Recommended name:
L-fuculose phosphate aldolase (EC:4.1.2.17)
Alternative name(s):
L-fuculose-1-phosphate aldolase
Gene namesi
Name:fucA
Ordered Locus Names:HI_0611
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216L-fuculose phosphate aldolaseUniRule annotationPRO_0000162928Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi71421.HI0611.

Structurei

3D structure databases

ProteinModelPortaliP44777.
SMRiP44777. Positions 1-210.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0235.
KOiK01628.
OMAiYATFGTH.
OrthoDBiEOG6HQSSQ.
PhylomeDBiP44777.

Family and domain databases

Gene3Di3.40.225.10. 1 hit.
HAMAPiMF_00987. FucA.
InterProiIPR001303. Aldolase_II/adducin_N.
IPR004782. FucA.
[Graphical view]
PfamiPF00596. Aldolase_II. 1 hit.
[Graphical view]
SMARTiSM01007. Aldolase_II. 1 hit.
[Graphical view]
SUPFAMiSSF53639. SSF53639. 1 hit.
TIGRFAMsiTIGR01086. fucA. 1 hit.

Sequencei

Sequence statusi: Complete.

P44777-1 [UniParc]FASTAAdd to Basket

« Hide

MNRAELSQKI IDTCLEMTKL GLNQGTAGNV SVRYKDGMLI TPTGMPYHLM    50
KTENIVYVDG NGKHEENKLP SSEWQFHLSV YHTRPEANAV VHNHSIHCAG 100
LSILEKPIPA IHYMVAVSGT DHIPCVPYAT FGSHKLASYV ATGIKESKAI 150
LLAHHGLITC GENLDKALWL AQEVEVLASW YLKLLSTGLE IPLLSKEQMQ 200
VVLGKFHTYG LRIEES 216
Length:216
Mass (Da):23,944
Last modified:November 1, 1995 - v1
Checksum:i4DBEEE21ED8EA6C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22270.1.
PIRiC64081.
RefSeqiNP_438769.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22270; AAC22270; HI_0611.
GeneIDi950000.
KEGGihin:HI0611.
PATRICi20189805. VBIHaeInf48452_0635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22270.1 .
PIRi C64081.
RefSeqi NP_438769.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44777.
SMRi P44777. Positions 1-210.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0611.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22270 ; AAC22270 ; HI_0611 .
GeneIDi 950000.
KEGGi hin:HI0611.
PATRICi 20189805. VBIHaeInf48452_0635.

Phylogenomic databases

eggNOGi COG0235.
KOi K01628.
OMAi YATFGTH.
OrthoDBi EOG6HQSSQ.
PhylomeDBi P44777.

Enzyme and pathway databases

UniPathwayi UPA00563 ; UER00626 .

Family and domain databases

Gene3Di 3.40.225.10. 1 hit.
HAMAPi MF_00987. FucA.
InterProi IPR001303. Aldolase_II/adducin_N.
IPR004782. FucA.
[Graphical view ]
Pfami PF00596. Aldolase_II. 1 hit.
[Graphical view ]
SMARTi SM01007. Aldolase_II. 1 hit.
[Graphical view ]
SUPFAMi SSF53639. SSF53639. 1 hit.
TIGRFAMsi TIGR01086. fucA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiFUCA_HAEIN
AccessioniPrimary (citable) accession number: P44777
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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