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P44777

- FUCA_HAEIN

UniProt

P44777 - FUCA_HAEIN

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Protein

L-fuculose phosphate aldolase

Gene

fucA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde.UniRule annotation

Catalytic activityi

L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731Proton acceptorUniRule annotation
Metal bindingi73 – 731ZincUniRule annotation
Metal bindingi92 – 921ZincUniRule annotation
Metal bindingi94 – 941ZincUniRule annotation
Active sitei113 – 1131Proton donorUniRule annotation
Metal bindingi155 – 1551ZincUniRule annotation

GO - Molecular functioni

  1. L-fuculose-phosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. fucose catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbohydrate metabolism, Fucose metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00563; UER00626.

Names & Taxonomyi

Protein namesi
Recommended name:
L-fuculose phosphate aldolaseUniRule annotation (EC:4.1.2.17UniRule annotation)
Alternative name(s):
L-fuculose-1-phosphate aldolaseUniRule annotation
Gene namesi
Name:fucAUniRule annotation
Ordered Locus Names:HI_0611
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216L-fuculose phosphate aldolasePRO_0000162928Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi71421.HI0611.

Structurei

3D structure databases

ProteinModelPortaliP44777.
SMRiP44777. Positions 1-210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldolase class II family. AraD/FucA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0235.
KOiK01628.
OMAiYATFGTH.
OrthoDBiEOG6HQSSQ.
PhylomeDBiP44777.

Family and domain databases

Gene3Di3.40.225.10. 1 hit.
HAMAPiMF_00987. FucA.
InterProiIPR001303. Aldolase_II/adducin_N.
IPR004782. FucA.
[Graphical view]
PfamiPF00596. Aldolase_II. 1 hit.
[Graphical view]
SMARTiSM01007. Aldolase_II. 1 hit.
[Graphical view]
SUPFAMiSSF53639. SSF53639. 1 hit.
TIGRFAMsiTIGR01086. fucA. 1 hit.

Sequencei

Sequence statusi: Complete.

P44777-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNRAELSQKI IDTCLEMTKL GLNQGTAGNV SVRYKDGMLI TPTGMPYHLM
60 70 80 90 100
KTENIVYVDG NGKHEENKLP SSEWQFHLSV YHTRPEANAV VHNHSIHCAG
110 120 130 140 150
LSILEKPIPA IHYMVAVSGT DHIPCVPYAT FGSHKLASYV ATGIKESKAI
160 170 180 190 200
LLAHHGLITC GENLDKALWL AQEVEVLASW YLKLLSTGLE IPLLSKEQMQ
210
VVLGKFHTYG LRIEES
Length:216
Mass (Da):23,944
Last modified:November 1, 1995 - v1
Checksum:i4DBEEE21ED8EA6C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22270.1.
PIRiC64081.
RefSeqiNP_438769.1. NC_000907.1.
WP_005694545.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22270; AAC22270; HI_0611.
GeneIDi950000.
KEGGihin:HI0611.
PATRICi20189805. VBIHaeInf48452_0635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22270.1 .
PIRi C64081.
RefSeqi NP_438769.1. NC_000907.1.
WP_005694545.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44777.
SMRi P44777. Positions 1-210.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0611.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22270 ; AAC22270 ; HI_0611 .
GeneIDi 950000.
KEGGi hin:HI0611.
PATRICi 20189805. VBIHaeInf48452_0635.

Phylogenomic databases

eggNOGi COG0235.
KOi K01628.
OMAi YATFGTH.
OrthoDBi EOG6HQSSQ.
PhylomeDBi P44777.

Enzyme and pathway databases

UniPathwayi UPA00563 ; UER00626 .

Family and domain databases

Gene3Di 3.40.225.10. 1 hit.
HAMAPi MF_00987. FucA.
InterProi IPR001303. Aldolase_II/adducin_N.
IPR004782. FucA.
[Graphical view ]
Pfami PF00596. Aldolase_II. 1 hit.
[Graphical view ]
SMARTi SM01007. Aldolase_II. 1 hit.
[Graphical view ]
SUPFAMi SSF53639. SSF53639. 1 hit.
TIGRFAMsi TIGR01086. fucA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiFUCA_HAEIN
AccessioniPrimary (citable) accession number: P44777
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3