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Protein

Shikimate 5-dehydrogenase-like protein HI_0607

Gene

HI_0607

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The physiological substrate is not known. Has much lower activity towards shikimate than AroE.1 Publication

Catalytic activityi

Shikimate + NAD(P)+ = 3-dehydroshikimate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei67Proton acceptorSequence analysis1
Binding sitei103SubstrateCurated1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi126 – 130NADPBy similarity5
Nucleotide bindingi235 – 239NADPBy similarity5

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BRENDAi1.1.1.282. 2529.

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate 5-dehydrogenase-like protein HI_0607 (EC:1.1.1.-)
Short name:
SDH-L
Gene namesi
Ordered Locus Names:HI_0607
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi67K → A, H or N: Loss of activity. 1 Publication1
Mutagenesisi103D → A or N: Loss of activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001360731 – 271Shikimate 5-dehydrogenase-like protein HI_0607Add BLAST271

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi71421.HI0607.

Structurei

Secondary structure

1271
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 12Combined sources6
Helixi19 – 31Combined sources13
Beta strandi35 – 40Combined sources6
Helixi45 – 55Combined sources11
Beta strandi59 – 62Combined sources4
Turni67 – 70Combined sources4
Helixi71 – 73Combined sources3
Beta strandi75 – 77Combined sources3
Helixi79 – 82Combined sources4
Turni83 – 85Combined sources3
Beta strandi89 – 93Combined sources5
Beta strandi96 – 100Combined sources5
Helixi102 – 113Combined sources12
Beta strandi122 – 125Combined sources4
Helixi131 – 140Combined sources10
Beta strandi146 – 149Combined sources4
Helixi153 – 163Combined sources11
Beta strandi166 – 169Combined sources4
Beta strandi177 – 181Combined sources5
Turni191 – 194Combined sources4
Helixi200 – 205Combined sources6
Beta strandi207 – 211Combined sources5
Beta strandi215 – 218Combined sources4
Helixi220 – 227Combined sources8
Beta strandi231 – 233Combined sources3
Helixi235 – 251Combined sources17
Helixi257 – 268Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NPYX-ray1.75A/B/C/D1-271[»]
ProteinModelPortaliP44774.
SMRiP44774.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP44774.

Family & Domainsi

Sequence similaritiesi

Belongs to the shikimate dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG4105F9E. Bacteria.
COG0169. LUCA.
KOiK00014.
OMAiHAYNTDY.
PhylomeDBiP44774.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR013708. Shikimate_DH-bd_N.
[Graphical view]
PfamiPF08501. Shikimate_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

P44774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINKDTQLCM SLSGRPSNFG TTFHNYLYDK LGLNFIYKAF TTQDIEHAIK
60 70 80 90 100
GVRALGIRGC AVSMPFKETC MPFLDEIHPS AQAIESVNTI VNDNGFLRAY
110 120 130 140 150
NTDYIAIVKL IEKYHLNKNA KVIVHGSGGM AKAVVAAFKN SGFEKLKIYA
160 170 180 190 200
RNVKTGQYLA ALYGYAYINS LENQQADILV NVTSIGMKGG KEEMDLAFPK
210 220 230 240 250
AFIDNASVAF DVVAMPVETP FIRYAQARGK QTISGAAVIV LQAVEQFELY
260 270
THQRPSDELI AEAAAFARTK F
Length:271
Mass (Da):29,932
Last modified:November 1, 1995 - v1
Checksum:iA7A6AC9B9388394E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22266.1.
PIRiH64080.
RefSeqiNP_438765.1. NC_000907.1.
WP_005694543.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22266; AAC22266; HI_0607.
GeneIDi949659.
KEGGihin:HI0607.
PATRICi20189793. VBIHaeInf48452_0631.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22266.1.
PIRiH64080.
RefSeqiNP_438765.1. NC_000907.1.
WP_005694543.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NPYX-ray1.75A/B/C/D1-271[»]
ProteinModelPortaliP44774.
SMRiP44774.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0607.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22266; AAC22266; HI_0607.
GeneIDi949659.
KEGGihin:HI0607.
PATRICi20189793. VBIHaeInf48452_0631.

Phylogenomic databases

eggNOGiENOG4105F9E. Bacteria.
COG0169. LUCA.
KOiK00014.
OMAiHAYNTDY.
PhylomeDBiP44774.

Enzyme and pathway databases

BRENDAi1.1.1.282. 2529.

Miscellaneous databases

EvolutionaryTraceiP44774.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR013708. Shikimate_DH-bd_N.
[Graphical view]
PfamiPF08501. Shikimate_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiY607_HAEIN
AccessioniPrimary (citable) accession number: P44774
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.