Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase

Gene

cpdB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'-cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate (By similarity).By similarity

Catalytic activityi

Nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate.
A 3'-ribonucleotide + H2O = a ribonucleoside + phosphate.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi41Divalent metal cation 1By similarity1
Metal bindingi43Divalent metal cation 1By similarity1
Metal bindingi86Divalent metal cation 1By similarity1
Metal bindingi86Divalent metal cation 2By similarity1
Metal bindingi126Divalent metal cation 2By similarity1
Metal bindingi235Divalent metal cation 2By similarity1
Metal bindingi267Divalent metal cation 2By similarity1
Metal bindingi269Divalent metal cation 1By similarity1
Binding sitei450SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Multifunctional enzyme
LigandMetal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-596-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase (EC:3.1.3.6, EC:3.1.4.16)
Gene namesi
Name:cpdB
Ordered Locus Names:HI_0583
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000000003727 – 6572',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidaseAdd BLAST631

Proteomic databases

PRIDEiP44764

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0583

Structurei

3D structure databases

ProteinModelPortaliP44764
SMRiP44764
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni554 – 559Substrate bindingBy similarity6

Sequence similaritiesi

Belongs to the 5'-nucleotidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4107RNS Bacteria
COG0737 LUCA
KOiK01119
OMAiMVWDKAN
PhylomeDBiP44764

Family and domain databases

Gene3Di3.60.21.10, 1 hit
3.90.780.10, 1 hit
InterProiView protein in InterPro
IPR008334 5'-Nucleotdase_C
IPR036907 5'-Nucleotdase_C_sf
IPR006146 5'-Nucleotdase_CS
IPR006179 5_nucleotidase/apyrase
IPR004843 Calcineurin-like_PHP_ApaH
IPR006294 Cyc_nuc_PDE_nucleotidase
IPR029052 Metallo-depent_PP-like
PANTHERiPTHR11575 PTHR11575, 1 hit
PfamiView protein in Pfam
PF02872 5_nucleotid_C, 1 hit
PF00149 Metallophos, 1 hit
PRINTSiPR01607 APYRASEFAMLY
SUPFAMiSSF55816 SSF55816, 1 hit
TIGRFAMsiTIGR01390 CycNucDiestase, 1 hit
PROSITEiView protein in PROSITE
PS00785 5_NUCLEOTIDASE_1, 1 hit
PS00786 5_NUCLEOTIDASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P44764-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNRRHFIQI SATSILALSA NRFAMAKGKS DVDLRIVATT DVHSFLTDFD
60 70 80 90 100
YYKDAPTDKF GFTRAASLIR QARAEVKNSV LVDNGDLIQG NPIADYQAAQ
110 120 130 140 150
GYKEGKSNPA IDCLNAMNYE VGTLGNHEFN YGLNYLADAI KQAKFPIVNS
160 170 180 190 200
NVVKAGTEEP YFTPYVIQEK SVVDNQGKTH KLKIGYIGFV PPQIMVWDKA
210 220 230 240 250
NLQGKVETRD IVKTAQKYVP EMKKKGADIV VALAHTGPSD EPYQEGAENS
260 270 280 290 300
AFYLADVPHI DAVIFGHSHR LFPNKEFAKS PNADIVNGTV KGIPESMAGY
310 320 330 340 350
WANNISVVDL GLTEHKGKWI VTSGKAVLRP IYDIETKKAL AKNDPEITAL
360 370 380 390 400
LKPVHEATRK YVSQPIGKAT DNMYSYLALL QDDPTIQIVN QAQKAYVEKV
410 420 430 440 450
APSIAAMAGL PILSAGAPFK AGGRKNDPTG YTEVNKGKLT FRNAADLYLY
460 470 480 490 500
PNTLVVVKAT GEQLKEWLEC SAGMFKQIDP TSDKPQSLID WEGFRTYNFD
510 520 530 540 550
VIDGVNYEYD LTKPARYDGE CKLINPESHR VVNLTYQGKP VDPKAEFLIA
560 570 580 590 600
TNNYRAYGNK FPGTGDKHIV YASPDESRQI LADYIKATSE KEGSVNPNAD
610 620 630 640 650
KNWRFVPITG NDKLDVRFET SPSEQAAKFI AEKAQYPMKQ VGTDEIGFAV

YQIDLSK
Length:657
Mass (Da):72,763
Last modified:November 1, 1995 - v1
Checksum:i201CAAB415014499
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC22242.1
PIRiA64079
RefSeqiNP_438741.1, NC_000907.1
WP_005694555.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC22242; AAC22242; HI_0583
GeneIDi949588
KEGGihin:HI0583
PATRICifig|71421.8.peg.604

Similar proteinsi

Entry informationi

Entry nameiCPDB_HAEIN
AccessioniPrimary (citable) accession number: P44764
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health