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P44764

- CPDB_HAEIN

UniProt

P44764 - CPDB_HAEIN

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Protein
2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase
Gene
cpdB, HI_0583
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'-cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate By similarity.

Catalytic activityi

Nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate.
A 3'-ribonucleotide + H2O = a ribonucleoside + phosphate.

Cofactori

Divalent cations By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi41 – 411Divalent metal cation 1 By similarity
Metal bindingi43 – 431Divalent metal cation 1 By similarity
Metal bindingi86 – 861Divalent metal cation 1 By similarity
Metal bindingi86 – 861Divalent metal cation 2 By similarity
Metal bindingi126 – 1261Divalent metal cation 2 By similarity
Metal bindingi235 – 2351Divalent metal cation 2 By similarity
Metal bindingi267 – 2671Divalent metal cation 2 By similarity
Metal bindingi269 – 2691Divalent metal cation 1 By similarity
Binding sitei450 – 4501Substrate By similarity

GO - Molecular functioni

  1. 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity Source: UniProtKB-EC
  2. 3'-nucleotidase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
  4. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. nucleotide catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase (EC:3.1.3.6, EC:3.1.4.16)
Gene namesi
Name:cpdB
Ordered Locus Names:HI_0583
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Periplasm By similarity

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 6576312',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase
PRO_0000000037Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0583.

Structurei

3D structure databases

ProteinModelPortaliP44764.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni554 – 5596Substrate binding By similarity

Sequence similaritiesi

Belongs to the 5'-nucleotidase family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0737.
KOiK01119.
K08693.
OMAiEKAQYPM.
OrthoDBiEOG696BW0.
PhylomeDBiP44764.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
3.90.780.10. 1 hit.
InterProiIPR008334. 5'-Nucleotdase_C.
IPR006146. 5'-Nucleotdase_CS.
IPR006179. 5_nucleotidase/apyrase.
IPR004843. Calcineurin-like_PHP_apaH.
IPR006294. Cyc_nuc_PDE_nucleotidase.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR11575. PTHR11575. 1 hit.
PfamiPF02872. 5_nucleotid_C. 1 hit.
PF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR01607. APYRASEFAMLY.
SUPFAMiSSF55816. SSF55816. 1 hit.
SSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR01390. CycNucDiestase. 1 hit.
PROSITEiPS00785. 5_NUCLEOTIDASE_1. 1 hit.
PS00786. 5_NUCLEOTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P44764-1 [UniParc]FASTAAdd to Basket

« Hide

MMNRRHFIQI SATSILALSA NRFAMAKGKS DVDLRIVATT DVHSFLTDFD    50
YYKDAPTDKF GFTRAASLIR QARAEVKNSV LVDNGDLIQG NPIADYQAAQ 100
GYKEGKSNPA IDCLNAMNYE VGTLGNHEFN YGLNYLADAI KQAKFPIVNS 150
NVVKAGTEEP YFTPYVIQEK SVVDNQGKTH KLKIGYIGFV PPQIMVWDKA 200
NLQGKVETRD IVKTAQKYVP EMKKKGADIV VALAHTGPSD EPYQEGAENS 250
AFYLADVPHI DAVIFGHSHR LFPNKEFAKS PNADIVNGTV KGIPESMAGY 300
WANNISVVDL GLTEHKGKWI VTSGKAVLRP IYDIETKKAL AKNDPEITAL 350
LKPVHEATRK YVSQPIGKAT DNMYSYLALL QDDPTIQIVN QAQKAYVEKV 400
APSIAAMAGL PILSAGAPFK AGGRKNDPTG YTEVNKGKLT FRNAADLYLY 450
PNTLVVVKAT GEQLKEWLEC SAGMFKQIDP TSDKPQSLID WEGFRTYNFD 500
VIDGVNYEYD LTKPARYDGE CKLINPESHR VVNLTYQGKP VDPKAEFLIA 550
TNNYRAYGNK FPGTGDKHIV YASPDESRQI LADYIKATSE KEGSVNPNAD 600
KNWRFVPITG NDKLDVRFET SPSEQAAKFI AEKAQYPMKQ VGTDEIGFAV 650
YQIDLSK 657
Length:657
Mass (Da):72,763
Last modified:November 1, 1995 - v1
Checksum:i201CAAB415014499
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22242.1.
PIRiA64079.
RefSeqiNP_438741.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22242; AAC22242; HI_0583.
GeneIDi949588.
KEGGihin:HI0583.
PATRICi20189723. VBIHaeInf48452_0604.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22242.1 .
PIRi A64079.
RefSeqi NP_438741.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44764.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0583.

Protocols and materials databases

DNASUi 949588.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22242 ; AAC22242 ; HI_0583 .
GeneIDi 949588.
KEGGi hin:HI0583.
PATRICi 20189723. VBIHaeInf48452_0604.

Phylogenomic databases

eggNOGi COG0737.
KOi K01119.
K08693.
OMAi EKAQYPM.
OrthoDBi EOG696BW0.
PhylomeDBi P44764.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
3.90.780.10. 1 hit.
InterProi IPR008334. 5'-Nucleotdase_C.
IPR006146. 5'-Nucleotdase_CS.
IPR006179. 5_nucleotidase/apyrase.
IPR004843. Calcineurin-like_PHP_apaH.
IPR006294. Cyc_nuc_PDE_nucleotidase.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
PANTHERi PTHR11575. PTHR11575. 1 hit.
Pfami PF02872. 5_nucleotid_C. 1 hit.
PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR01607. APYRASEFAMLY.
SUPFAMi SSF55816. SSF55816. 1 hit.
SSF56300. SSF56300. 1 hit.
TIGRFAMsi TIGR01390. CycNucDiestase. 1 hit.
PROSITEi PS00785. 5_NUCLEOTIDASE_1. 1 hit.
PS00786. 5_NUCLEOTIDASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiCPDB_HAEIN
AccessioniPrimary (citable) accession number: P44764
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi