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Reviewed, UniProtKB/Swiss-Prot P44758 (PRX5_HAEIN)

Last modified June 16, 2009. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Hybrid peroxiredoxin hyPrx5
    EC=1.11.1.15
Alternative name(s):
    Thioredoxin reductase
Gene names
Ordered Locus Names: HI0572
OrganismHaemophilus influenzae [Complete proteome] [HAMAP]
Taxonomic identifier727 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

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Protein attributes

Sequence length241 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Catalytic activity

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.

Subunit structure

Homotetramer.

Sequence similarities

Contains 1 glutaredoxin domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 241241Hybrid peroxiredoxin hyPrx5
PRO_0000056612

Regions

Domain170 – 24172Glutaredoxin
Region1 – 169169Peroxiredoxin-like

Sites

Active site491Cysteine sulfenic acid (-SOH) intermediate By similarity

Amino acid modifications

Disulfide bond180 ↔ 183Redox-active

Secondary structure

1 ................................................. 241
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P44758-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: D2FD230D20BE63F0

FASTA24126,743
        10         20         30         40         50         60 
MSSMEGKKVP QVTFRTRQGD KWVDVTTSEL FDNKTVIVFS LPGAFTPTCS SSHLPRYNEL 

        70         80         90        100        110        120 
APVFKKYGVD DILVVSVNDT FVMNAWKEDE KSENISFIPD GNGEFTEGMG MLVGKEDLGF 

       130        140        150        160        170        180 
GKRSWRYSML VKNGVVEKMF IEPNEPGDPF KVSDADTMLK YLAPQHQVQE SISIFTKPGC 

       190        200        210        220        230        240 
PFCAKAKQLL HDKGLSFEEI ILGHDATIVS VRAVSGRTTV PQVFIGGKHI GGSDDLEKYF 


A

« Hide

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References

« Hide 'large scale' references
[1]"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd."
Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. expand/collapse author list , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C.
Science 269:496-512(1995) [PubMed: 7542800] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[2]"Two-dimensional map of the proteome of Haemophilus influenzae."
Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C., Fountoulakis M.
Electrophoresis 21:411-429(2000) [PubMed: 10675023] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
[3]"The tetrameric structure of Haemophilus influenza hybrid Prx5 reveals interactions between electron donor and acceptor proteins."
Kim S.J., Woo J.R., Hwang Y.S., Jeong D.G., Shin D.H., Kim K., Ryu S.E.
J. Biol. Chem. 278:10790-10798(2003) [PubMed: 12529327] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).

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Cross-references

Sequence databases

L42023 Genomic DNA. Translation: AAC22230.1.
PIRI64154.
RefSeqNP_438729.1.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1NM3X-ray2.80A/B1-241[»]
ModBaseSearch...

Protein family/group databases

PeroxiBase4786. HinPrxGrx_KW20.

Genome annotation databases

GeneID950101.
GenomeReviewsGene locus HI0572 in contig L42023_GR.
KEGGhin:HI0572.
NMPDRfig|71421.1.peg.542.
TIGRHI0572.

Phylogenomic databases

HOGENOMP44758.
OMAP44758. VMNEWAK.

Enzyme and pathway databases

BioCycHINF71421:HI_0572-MON.
BRENDA1.11.1.15. 109.

Family and domain databases

InterProIPR011767. GLR_AS.
IPR011906. GlrX-dom.
IPR002109. Glutaredoxin.
IPR014025. Glutaredoxin_sub.
IPR013740. Redoxin.
IPR012335. Thioredoxin_fold.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 2 hits.
PfamPF00462. Glutaredoxin. 1 hit.
PF08534. Redoxin. 1 hit.
[Graphical view]
PRINTSPR00160. GLUTAREDOXIN.
TIGRFAMsTIGR02190. GlrX-dom. 1 hit.
PROSITEPS00195. GLUTAREDOXIN_1. 1 hit.
PS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry namePRX5_HAEIN
AccessionPrimary (citable) accession number: P44758
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 16, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents