P44738 (RRAA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulator of ribonuclease activity A

Gene names

Name:	rraA
Ordered Locus Names:	HI_0508

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	162 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome By similarity. HAMAP MF_00471
Subunit structure	Homotrimer. Binds to both RNA-binding sites in the C-terminal region of Rne and to RhlB By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00471.
Sequence similarities	Belongs to the RraA family.

Ontologies

Keywords
Cellular component	Cytoplasm
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of RNA metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ribonuclease inhibitor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 162	162	Regulator of ribonuclease activity A HAMAP MF_00471		PRO_0000209616

Sequences

	Sequence		Length	Mass (Da)
	P44738 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: B86E0E9BD2D8796A	FASTA	162	17,388
	10 20 30 40 50 60 MFIDTSELCD LYAEQVDVVE PIFSSFGGVS NFYGKVTTVK CFESNGLIAE VLEENGEGRV 70 80 90 100 110 120 LVIDGGGAVR RGLIDAELAQ LAVDNGWEGI IVYGAVRQIQ QLENLDIGIH ALAPIPVSAD 130 140 150 160 ESSAGESDIP VNFGGVTFFP EDYIYADLTG IILSQEPLDL ED

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC22166.1.
PIR	G64153.
RefSeq	NP_438666.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P44738.
SMR	P44738. Positions 4-161.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	949667.
GenomeReviews	Gene locus HI_0508 in contig L42023_GR.
KEGG	hin:HI0508.
NMPDR	fig|71421.1.peg.479.
PATRIC	20189569. VBIHaeInf48452_0527.
TIGR	HI_0508.
Phylogenomic databases
HOGENOM	HBG668175.
OMA	QNEWEGI.
ProtClustDB	PRK09372.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0508-MONOMER.
Family and domain databases
HAMAP	MF_00471. RraA. [Tree]
InterPro	IPR005493. RNase_E_inh/diMeMenaQ_MeTrfase. IPR010203. RraA. IPR014339. RraA_gpbac. [Graphical view]
Gene3D	G3DSA:3.50.30.40. RNaseE_inh/diMeMenaQ_MeTrfase. 1 hit.
KO	K02553.
Pfam	PF03737. Methyltransf_6. 1 hit. [Graphical view]
SUPFAM	SSF89562. RNaseE_inh/diMeMenaQ_MeTrfase. 1 hit.
TIGRFAMs	TIGR01935. NOT-MenG. 1 hit. TIGR02998. RraA_entero. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RRAA_HAEIN

Accession

Primary (citable) accession number: P44738

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program