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Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotation

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-5-phosphate isomerase A (rpiA)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei103 – 1031Proton acceptorUniRule annotation
Binding sitei121 – 1211SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)
Alternative name(s):
Phosphoriboisomerase AUniRule annotation
Short name:
PRIUniRule annotation
Gene namesi
Name:rpiAUniRule annotation
Ordered Locus Names:HI_0464
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Ribose-5-phosphate isomerase APRO_0000158423Add
BLAST

Proteomic databases

PRIDEiP44725.

Interactioni

Subunit structurei

Homodimer.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi71421.HI0464.

Structurei

Secondary structure

1
219
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1412Combined sources
Helixi15 – 173Combined sources
Beta strandi22 – 265Combined sources
Helixi30 – 4011Combined sources
Helixi41 – 455Combined sources
Beta strandi48 – 536Combined sources
Helixi54 – 629Combined sources
Helixi70 – 723Combined sources
Beta strandi76 – 816Combined sources
Beta strandi84 – 863Combined sources
Helixi100 – 10910Combined sources
Beta strandi110 – 1189Combined sources
Helixi119 – 1213Combined sources
Beta strandi128 – 1303Combined sources
Beta strandi132 – 1365Combined sources
Helixi138 – 1403Combined sources
Helixi141 – 15010Combined sources
Beta strandi154 – 1574Combined sources
Beta strandi168 – 1747Combined sources
Helixi180 – 1889Combined sources
Beta strandi193 – 1997Combined sources
Beta strandi205 – 2117Combined sources
Beta strandi214 – 2185Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1M0SX-ray1.90A/B1-219[»]
ProteinModelPortaliP44725.
SMRiP44725. Positions 1-219.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP44725.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni28 – 314Substrate binding
Regioni81 – 844Substrate bindingCurated
Regioni94 – 974Substrate binding

Sequence similaritiesi

Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E66. Bacteria.
COG0120. LUCA.
KOiK01807.
OMAiGACHVQE.
PhylomeDBiP44725.

Family and domain databases

CDDicd01398. RPI_A. 1 hit.
HAMAPiMF_00170. Rib_5P_isom_A. 1 hit.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.

Sequencei

Sequence statusi: Complete.

P44725-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQLEMKKLA AQAALQYVKA DTIVGVGSGS TVNCFIEALG TIKDKIQGAV
60 70 80 90 100
AASKESEELL RKQGIEVFNA NDVSSLDIYV DGADEINPQK MMIKGGGAAL
110 120 130 140 150
TREKIVAALA KKFICIVDSS KQVDVLGSTF PLPVEVIPMA RSQVGRKLAA
160 170 180 190 200
LGGSPEYREG VVTDNGNVIL DVHNFSILNP VEIEKELNNV AGVVTNGIFA
210
LRGADVVIVG TPEGAKVID
Length:219
Mass (Da):23,094
Last modified:November 1, 1995 - v1
Checksum:iBB8ABD085BADA3C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22123.1.
PIRiB64153.
RefSeqiNP_438625.1. NC_000907.1.
WP_005693699.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22123; AAC22123; HI_0464.
GeneIDi949550.
KEGGihin:HI0464.
PATRICi20189483. VBIHaeInf48452_0484.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22123.1.
PIRiB64153.
RefSeqiNP_438625.1. NC_000907.1.
WP_005693699.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1M0SX-ray1.90A/B1-219[»]
ProteinModelPortaliP44725.
SMRiP44725. Positions 1-219.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0464.

Proteomic databases

PRIDEiP44725.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22123; AAC22123; HI_0464.
GeneIDi949550.
KEGGihin:HI0464.
PATRICi20189483. VBIHaeInf48452_0484.

Phylogenomic databases

eggNOGiENOG4105E66. Bacteria.
COG0120. LUCA.
KOiK01807.
OMAiGACHVQE.
PhylomeDBiP44725.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412.

Miscellaneous databases

EvolutionaryTraceiP44725.

Family and domain databases

CDDicd01398. RPI_A. 1 hit.
HAMAPiMF_00170. Rib_5P_isom_A. 1 hit.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRPIA_HAEIN
AccessioniPrimary (citable) accession number: P44725
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.