P44725 (RPIA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribose-5-phosphate isomerase A
EC=5.3.1.6

Alternative name(s):
Phosphoriboisomerase A
Short name=PRI

Gene names

Name:	rpiA
Ordered Locus Names:	HI_0464

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	D-ribose 5-phosphate = D-ribulose 5-phosphate. HAMAP-Rule MF_00170
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1. HAMAP-Rule MF_00170
Sequence similarities	Belongs to the ribose 5-phosphate isomerase family.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	pentose-phosphate shunt, non-oxidative branch Inferred from electronic annotation. Source: HAMAP
Molecular_function	ribose-5-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 219

219

Ribose-5-phosphate isomerase A HAMAP-Rule MF_00170

PRO_0000158423

Secondary structure

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219

Helix Strand Turn

Details...

Helix

3 – 14

12

Helix

15 – 17

3

Beta strand

22 – 26

5

Helix

30 – 40

11

Helix

41 – 45

5

Beta strand

48 – 53

6

Helix

54 – 62

9

Helix

70 – 72

3

Beta strand

76 – 81

6

Beta strand

84 – 86

3

Helix

100 – 109

10

Beta strand

110 – 118

9

Helix

119 – 121

3

Beta strand

128 – 130

3

Beta strand

132 – 136

5

Helix

138 – 140

3

Helix

141 – 150

10

Beta strand

154 – 157

4

Beta strand

168 – 174

7

Helix

180 – 188

9

Beta strand

193 – 199

7

Beta strand

205 – 211

7

Beta strand

214 – 218

5

Sequences

	Sequence		Length	Mass (Da)
	P44725 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: BB8ABD085BADA3C1	FASTA	219	23,094
	10 20 30 40 50 60 MNQLEMKKLA AQAALQYVKA DTIVGVGSGS TVNCFIEALG TIKDKIQGAV AASKESEELL 70 80 90 100 110 120 RKQGIEVFNA NDVSSLDIYV DGADEINPQK MMIKGGGAAL TREKIVAALA KKFICIVDSS 130 140 150 160 170 180 KQVDVLGSTF PLPVEVIPMA RSQVGRKLAA LGGSPEYREG VVTDNGNVIL DVHNFSILNP 190 200 210 VEIEKELNNV AGVVTNGIFA LRGADVVIVG TPEGAKVID

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[2]	"Two-dimensional map of the proteome of Haemophilus influenzae." Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C., Fountoulakis M. Electrophoresis 21:411-429(2000) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L42023 Genomic DNA. Translation: AAC22123.1.

PIR

B64153.

RefSeq

NP_438625.1. NC_000907.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1M0S	X-ray	1.90	A/B	1-219	[»]

ProteinModelPortal

P44725.

SMR

P44725. Positions 1-219.

ModBase

Search...

Protein-protein interaction databases

STRING

71421.HI0464.

Proteomic databases

PRIDE

P44725.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAC22123; AAC22123; HI_0464.

GeneID

949550.

KEGG

hin:HI0464.

PATRIC

20189483. VBIHaeInf48452_0484.

Phylogenomic databases

eggNOG

COG0120.

KO

K01807.

OMA

STTAYFI.

ProtClustDB

PRK00702.

Enzyme and pathway databases

UniPathway

UPA00115; UER00412.

Family and domain databases

HAMAP

MF_00170. Rib_5P_isom_A.

InterPro

IPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]

PANTHER

PTHR11934. PTHR11934. 1 hit.

Pfam

PF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00021. rpiA. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

P44725.

Entry information

Entry name

RPIA_HAEIN

Accession

Primary (citable) accession number: P44725

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program