P44719 (KTHY_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidylate kinase
EC=2.7.4.9

Alternative name(s):
dTMP kinase

Gene names

Name:	tmk
Ordered Locus Names:	HI_0456

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. HAMAP MF_00165
Catalytic activity	ATP + dTMP = ADP + dTDP. HAMAP MF_00165
Sequence similarities	Belongs to the thymidylate kinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	dTDP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thymidylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Thymidylate kinase HAMAP MF_00165		PRO_0000155281
Regions
	Nucleotide binding	10 – 17	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P44719 [UniParc]. Last modified October 1, 1996. Version 2. Checksum: C577F00602A0F204	FASTA	210	23,693
	10 20 30 40 50 60 MKGKFIVIEG LEGAGKSSAH QSVVRVLHEL GIQDVVFTRE PGGTPLAEKL RHLIKHETEE 70 80 90 100 110 120 PVTDKAELLM LYAARIQLVE NVIKPALMQG KWVVGDRHDM SSQAYQGGGR QLDPHFMLTL 130 140 150 160 170 180 KETVLGNFEP DLTIYLDIDP SVGLARARGR GELDRIEQMD LDFFHRTRAR YLELVKDNPK 190 200 210 AVVINAEQSI ELVQADIESA VKNWWKSNEK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[2]	"Two-dimensional map of the proteome of Haemophilus influenzae." Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C., Fountoulakis M. Electrophoresis 21:411-429(2000) [PubMed: 10675023] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC22114.1.
RefSeq	NP_438617.2. NC_000907.1.
3D structure databases
ProteinModelPortal	P44719.
SMR	P44719. Positions 2-206.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	949547.
GenomeReviews	Gene locus HI_0456 in contig L42023_GR.
KEGG	hin:HI0456.
NMPDR	fig|71421.1.peg.430.
PATRIC	20189467. VBIHaeInf48452_0476.
TIGR	HI_0456.
Phylogenomic databases
HOGENOM	HBG626009.
OMA	RFITFEG.
PhylomeDB	P44719.
ProtClustDB	PRK00698.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0456-MONOMER.
Family and domain databases
HAMAP	MF_00165. Thymidylate_kinase. [Tree]
InterPro	IPR018095. Thymidylate_kin_CS. IPR018094. Thymidylate_kinase. [Graphical view]
KO	K00943.
PANTHER	PTHR10344. Thymidylate_kin. 1 hit.
Pfam	PF02223. Thymidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00041. DTMP_kinase. 1 hit.
PROSITE	PS01331. THYMIDYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KTHY_HAEIN

Accession

Primary (citable) accession number: P44719

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	October 1, 1996
Last modified:	January 25, 2012
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program