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P44715

- PTFAH_HAEIN

UniProt

P44715 - PTFAH_HAEIN

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Protein

Multiphosphoryl transfer protein

Gene

fruB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport (By similarity).By similarity

Catalytic activityi

Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei62 – 621Tele-phosphohistidine intermediate; for EIIA activityPROSITE-ProRule annotation
Active sitei300 – 3001Pros-phosphohistidine intermediate; for HPr activityPROSITE-ProRule annotation
Active sitei424 – 4241Pros-phosphohistidine intermediate; for HPr activityPROSITE-ProRule annotation

GO - Molecular functioni

  1. kinase activity Source: UniProtKB-KW
  2. transporter activity Source: InterPro

GO - Biological processi

  1. phosphoenolpyruvate-dependent sugar phosphotransferase system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Phosphotransferase system, Sugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Multiphosphoryl transfer protein
Short name:
MTP
Alternative name(s):
Fructose PTS diphosphoryl transfer protein
Phosphotransferase FPr protein
Pseudo-HPr
Including the following 2 domains:
Phosphocarrier protein HPr
Short name:
Protein H
Fructose-specific phosphotransferase enzyme IIA component (EC:2.7.1.-)
Alternative name(s):
EIIA-Fru
EIII-Fru
PTS system fructose-specific EIIA component
Gene namesi
Name:fruB
Ordered Locus Names:HI_0448
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Multiphosphoryl transfer proteinPRO_0000186520Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0448.

Structurei

3D structure databases

ProteinModelPortaliP44715.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 142141PTS EIIA type-2PROSITE-ProRule annotationAdd
BLAST
Domaini286 – 37691HPr 1PROSITE-ProRule annotationAdd
BLAST
Domaini410 – 49990HPr 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni155 – 285131M domainAdd
BLAST
Regioni378 – 40932LinkerAdd
BLAST

Domaini

In contrast to classical PTS systems, the fructose PTS has no requirement for HPr; FPr combines a IIA domain with two HPr domains.1 Publication
The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain.1 PublicationPROSITE-ProRule annotation

Sequence similaritiesi

Contains 2 HPr domains.PROSITE-ProRule annotation
Contains 1 PTS EIIA type-2 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1925.
KOiK02768.
K11183.
OMAiFPQGIAW.
OrthoDBiEOG6XDGX2.
PhylomeDBiP44715.

Family and domain databases

Gene3Di3.30.1340.10. 2 hits.
3.40.930.10. 1 hit.
InterProiIPR000032. HPr_prot-like.
IPR016258. Phosphotransferase_sys_FPr.
IPR016152. PTrfase/Anion_transptr.
IPR002178. PTS_EIIA_type-2_dom.
IPR001020. PTS_HPr_His_P_site.
IPR002114. PTS_HPr_Ser_P_site.
[Graphical view]
PfamiPF00381. PTS-HPr. 2 hits.
PF00359. PTS_EIIA_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000690. Fruc_PTS_diPryltransf. 1 hit.
PRINTSiPR00107. PHOSPHOCPHPR.
SUPFAMiSSF55594. SSF55594. 2 hits.
SSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR01003. PTS_HPr_family. 2 hits.
PROSITEiPS51094. PTS_EIIA_TYPE_2. 1 hit.
PS00372. PTS_EIIA_TYPE_2_HIS. 1 hit.
PS51350. PTS_HPR_DOM. 2 hits.
PS00369. PTS_HPR_HIS. 2 hits.
PS00589. PTS_HPR_SER. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44715-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLELSESNIH LNANAIDKQQ AIEMAVSALV QAGNVENGYL QGMLARELQT
60 70 80 90 100
STFLGNGIAI PHGTLDTRLM VKKTGVQVFQ FPQGIEWGEG NIAYVVIGIA
110 120 130 140 150
ARSDEHLSLL RQLTHVLSDE DTAAKLAKIT DVAEFCAILM GETIDPFEIP
160 170 180 190 200
AANISLDVNT QSLLTLVAIN AGQLQVQSAV ENRFISEVIN NAALPLGKGL
210 220 230 240 250
WVTDSVVGNV KNALAFSRAK TIFSHNGKAV KGVITVSAVG DQINPTLVRL
260 270 280 290 300
LDDDVQTTLL NGNSTEILTA LLGSSSDVET QSVEGAVVGT FTIRNEHGLH
310 320 330 340 350
ARPSANLVNE VKKFTSKITM QNLTRESEVV SAKSLMKIVA LGVTQGHRLR
360 370 380 390 400
FVAEGEDAKQ AIESLGKAIA NGLGENVSAV PPSEPDTIEI MGDQIHTPAV
410 420 430 440 450
TEDDNLPANA IEAVFVIKNE QGLHARPSAI LVNEVKKYNA SVAVQNLDRN
460 470 480 490
SQLVSAKSLM KIVALGVVKG TRLRFVATGE EAQQAIDGIG AVIESGLGE
Length:499
Mass (Da):53,007
Last modified:November 1, 1995 - v1
Checksum:iD6DDC99884A58C63
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22107.1.
PIRiB64069.
RefSeqiNP_438609.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22107; AAC22107; HI_0448.
GeneIDi950651.
KEGGihin:HI0448.
PATRICi20189451. VBIHaeInf48452_0468.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22107.1 .
PIRi B64069.
RefSeqi NP_438609.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44715.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0448.

Protocols and materials databases

DNASUi 950651.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22107 ; AAC22107 ; HI_0448 .
GeneIDi 950651.
KEGGi hin:HI0448.
PATRICi 20189451. VBIHaeInf48452_0468.

Phylogenomic databases

eggNOGi COG1925.
KOi K02768.
K11183.
OMAi FPQGIAW.
OrthoDBi EOG6XDGX2.
PhylomeDBi P44715.

Family and domain databases

Gene3Di 3.30.1340.10. 2 hits.
3.40.930.10. 1 hit.
InterProi IPR000032. HPr_prot-like.
IPR016258. Phosphotransferase_sys_FPr.
IPR016152. PTrfase/Anion_transptr.
IPR002178. PTS_EIIA_type-2_dom.
IPR001020. PTS_HPr_His_P_site.
IPR002114. PTS_HPr_Ser_P_site.
[Graphical view ]
Pfami PF00381. PTS-HPr. 2 hits.
PF00359. PTS_EIIA_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000690. Fruc_PTS_diPryltransf. 1 hit.
PRINTSi PR00107. PHOSPHOCPHPR.
SUPFAMi SSF55594. SSF55594. 2 hits.
SSF55804. SSF55804. 2 hits.
TIGRFAMsi TIGR01003. PTS_HPr_family. 2 hits.
PROSITEi PS51094. PTS_EIIA_TYPE_2. 1 hit.
PS00372. PTS_EIIA_TYPE_2_HIS. 1 hit.
PS51350. PTS_HPR_DOM. 2 hits.
PS00369. PTS_HPR_HIS. 2 hits.
PS00589. PTS_HPR_SER. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. "Novel PTS proteins revealed by bacterial genome sequencing: a unique fructose-specific phosphoryl transfer protein with two HPr-like domains in Haemophilus influenzae."
    Reizer J., Reizer A., Saier M.H. Jr.
    Res. Microbiol. 147:209-215(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN STRUCTURE.

Entry informationi

Entry nameiPTFAH_HAEIN
AccessioniPrimary (citable) accession number: P44715
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3