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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei605For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-444-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:HI_0429
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001353392 – 610Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST609

Proteomic databases

PRIDEiP44708

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi71421.HI0429

Structurei

3D structure databases

ProteinModelPortaliP44708
SMRiP44708
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 218Glutamine amidotransferase type-2UniRule annotationAdd BLAST217
Domaini278 – 426SIS 1UniRule annotationAdd BLAST149
Domaini459 – 600SIS 2UniRule annotationAdd BLAST142

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
KOiK00820
OMAiASEYRYA
PhylomeDBiP44708

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.101 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P44708-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGAVAQ RDVAEILING LHRLEYRGYD SAGVAVINKQ NELQRIRCLG
60 70 80 90 100
KVKALDEAVS EKPLIGGTGI AHTRWATHGE PSETNAHPHS SGTFAVVHNG
110 120 130 140 150
IIENHEELRE LLKSRGYVFL SQTDTEVIAH LVEWEMRTTD SLLDAVKKAV
160 170 180 190 200
KQLTGAYGMV VMDSRHPEHL VAARSGSPLV IGLGIGENFL ASDQLALLSV
210 220 230 240 250
TRRFIFLEEG DIAEITRRTV DIYDTHGNKA KREIHESNLE NDAAEKGKFR
260 270 280 290 300
HFMQKEIYEQ PTALINTMEG RINHENVIVD SIGNGAKGIL EKVEHIQIVA
310 320 330 340 350
CGTSYNAGMV ARYWFESLAG VSCDVEIASE FRYRKFVTRP NSLLITLSQS
360 370 380 390 400
GETADTLAAL RLAKEKGYMA ALTICNVAGS SLVRESDLAF MTRAGVEVGV
410 420 430 440 450
ASTKAFTTQL AALLMLVTAL GKVKGHISVE KEREIIKAMQ SLPAEIEKAL
460 470 480 490 500
AFDTEIEALA EDFAEKHHAL FLGRGAFYPI AVEASLKLKE ISYIHAEAYA
510 520 530 540 550
AGELKHGPLA LIDADMPVIV VAPNNELLEK VKSNIEEVRA RGGQLYVFAD
560 570 580 590 600
KEAGFTPSEG MKIITMPKVN DIVAPIFYTI PMQLLSYYVA LIKGTDVDQP
610
RNLAKSVTVE
Length:610
Mass (Da):66,832
Last modified:January 23, 2007 - v2
Checksum:iAAEE87EF0B4E6D3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC22088.1
PIRiD64067
RefSeqiNP_438590.1, NC_000907.1
WP_010868986.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC22088; AAC22088; HI_0429
GeneIDi950659
KEGGihin:HI0429
PATRICifig|71421.8.peg.449

Similar proteinsi

Entry informationi

Entry nameiGLMS_HAEIN
AccessioniPrimary (citable) accession number: P44708
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome