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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei605 – 6051For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:HI_0429
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 610609Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135339Add
BLAST

Proteomic databases

PRIDEiP44708.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi71421.HI0429.

Structurei

3D structure databases

ProteinModelPortaliP44708.
SMRiP44708. Positions 2-610.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 218217Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini278 – 426149SIS 1UniRule annotationAdd
BLAST
Domaini459 – 600142SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
KOiK00820.
OMAiGEFFCAS.
OrthoDBiEOG6KT2Q1.
PhylomeDBiP44708.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF00310. GATase_2. 2 hits.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P44708-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGAVAQ RDVAEILING LHRLEYRGYD SAGVAVINKQ NELQRIRCLG
60 70 80 90 100
KVKALDEAVS EKPLIGGTGI AHTRWATHGE PSETNAHPHS SGTFAVVHNG
110 120 130 140 150
IIENHEELRE LLKSRGYVFL SQTDTEVIAH LVEWEMRTTD SLLDAVKKAV
160 170 180 190 200
KQLTGAYGMV VMDSRHPEHL VAARSGSPLV IGLGIGENFL ASDQLALLSV
210 220 230 240 250
TRRFIFLEEG DIAEITRRTV DIYDTHGNKA KREIHESNLE NDAAEKGKFR
260 270 280 290 300
HFMQKEIYEQ PTALINTMEG RINHENVIVD SIGNGAKGIL EKVEHIQIVA
310 320 330 340 350
CGTSYNAGMV ARYWFESLAG VSCDVEIASE FRYRKFVTRP NSLLITLSQS
360 370 380 390 400
GETADTLAAL RLAKEKGYMA ALTICNVAGS SLVRESDLAF MTRAGVEVGV
410 420 430 440 450
ASTKAFTTQL AALLMLVTAL GKVKGHISVE KEREIIKAMQ SLPAEIEKAL
460 470 480 490 500
AFDTEIEALA EDFAEKHHAL FLGRGAFYPI AVEASLKLKE ISYIHAEAYA
510 520 530 540 550
AGELKHGPLA LIDADMPVIV VAPNNELLEK VKSNIEEVRA RGGQLYVFAD
560 570 580 590 600
KEAGFTPSEG MKIITMPKVN DIVAPIFYTI PMQLLSYYVA LIKGTDVDQP
610
RNLAKSVTVE
Length:610
Mass (Da):66,832
Last modified:January 23, 2007 - v2
Checksum:iAAEE87EF0B4E6D3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22088.1.
PIRiD64067.
RefSeqiNP_438590.1. NC_000907.1.
WP_010868986.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22088; AAC22088; HI_0429.
GeneIDi950659.
KEGGihin:HI0429.
PATRICi20189411. VBIHaeInf48452_0449.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22088.1.
PIRiD64067.
RefSeqiNP_438590.1. NC_000907.1.
WP_010868986.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP44708.
SMRiP44708. Positions 2-610.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0429.

Protein family/group databases

MEROPSiC44.971.

Proteomic databases

PRIDEiP44708.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22088; AAC22088; HI_0429.
GeneIDi950659.
KEGGihin:HI0429.
PATRICi20189411. VBIHaeInf48452_0449.

Phylogenomic databases

eggNOGiCOG0449.
KOiK00820.
OMAiGEFFCAS.
OrthoDBiEOG6KT2Q1.
PhylomeDBiP44708.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF00310. GATase_2. 2 hits.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiGLMS_HAEIN
AccessioniPrimary (citable) accession number: P44708
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: July 22, 2015
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.