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P44708

- GLMS_HAEIN

UniProt

P44708 - GLMS_HAEIN

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei605 – 6051For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:HI_0429
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 610609Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135339Add
    BLAST

    Proteomic databases

    PRIDEiP44708.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi71421.HI0429.

    Structurei

    3D structure databases

    ProteinModelPortaliP44708.
    SMRiP44708. Positions 2-610.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 218217Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini278 – 426149SIS 1UniRule annotationAdd
    BLAST
    Domaini459 – 600142SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    KOiK00820.
    OMAiPVTRRFM.
    OrthoDBiEOG6KT2Q1.
    PhylomeDBiP44708.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF00310. GATase_2. 2 hits.
    PF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P44708-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCGIVGAVAQ RDVAEILING LHRLEYRGYD SAGVAVINKQ NELQRIRCLG    50
    KVKALDEAVS EKPLIGGTGI AHTRWATHGE PSETNAHPHS SGTFAVVHNG 100
    IIENHEELRE LLKSRGYVFL SQTDTEVIAH LVEWEMRTTD SLLDAVKKAV 150
    KQLTGAYGMV VMDSRHPEHL VAARSGSPLV IGLGIGENFL ASDQLALLSV 200
    TRRFIFLEEG DIAEITRRTV DIYDTHGNKA KREIHESNLE NDAAEKGKFR 250
    HFMQKEIYEQ PTALINTMEG RINHENVIVD SIGNGAKGIL EKVEHIQIVA 300
    CGTSYNAGMV ARYWFESLAG VSCDVEIASE FRYRKFVTRP NSLLITLSQS 350
    GETADTLAAL RLAKEKGYMA ALTICNVAGS SLVRESDLAF MTRAGVEVGV 400
    ASTKAFTTQL AALLMLVTAL GKVKGHISVE KEREIIKAMQ SLPAEIEKAL 450
    AFDTEIEALA EDFAEKHHAL FLGRGAFYPI AVEASLKLKE ISYIHAEAYA 500
    AGELKHGPLA LIDADMPVIV VAPNNELLEK VKSNIEEVRA RGGQLYVFAD 550
    KEAGFTPSEG MKIITMPKVN DIVAPIFYTI PMQLLSYYVA LIKGTDVDQP 600
    RNLAKSVTVE 610
    Length:610
    Mass (Da):66,832
    Last modified:January 23, 2007 - v2
    Checksum:iAAEE87EF0B4E6D3F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22088.1.
    PIRiD64067.
    RefSeqiNP_438590.1. NC_000907.1.
    WP_010868986.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22088; AAC22088; HI_0429.
    GeneIDi950659.
    KEGGihin:HI0429.
    PATRICi20189411. VBIHaeInf48452_0449.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22088.1 .
    PIRi D64067.
    RefSeqi NP_438590.1. NC_000907.1.
    WP_010868986.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44708.
    SMRi P44708. Positions 2-610.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0429.

    Protein family/group databases

    MEROPSi C44.971.

    Proteomic databases

    PRIDEi P44708.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22088 ; AAC22088 ; HI_0429 .
    GeneIDi 950659.
    KEGGi hin:HI0429.
    PATRICi 20189411. VBIHaeInf48452_0449.

    Phylogenomic databases

    eggNOGi COG0449.
    KOi K00820.
    OMAi PVTRRFM.
    OrthoDBi EOG6KT2Q1.
    PhylomeDBi P44708.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF00310. GATase_2. 2 hits.
    PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiGLMS_HAEIN
    AccessioniPrimary (citable) accession number: P44708
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3