Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CDP-diacylglycerol--serine O-phosphatidyltransferase

Gene

pssA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

CDP-diacylglycerol + L-serine = CMP + (3-sn-phosphatidyl)-L-serine.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-diacylglycerol--serine O-phosphatidyltransferase (EC:2.7.8.8)
Alternative name(s):
Phosphatidylserine synthase
Gene namesi
Name:pssA
Ordered Locus Names:HI_0425
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455CDP-diacylglycerol--serine O-phosphatidyltransferasePRO_0000056825Add
BLAST

Interactioni

Subunit structurei

Multimeric.

Protein-protein interaction databases

STRINGi71421.HI0425.

Structurei

Secondary structure

1
455
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1410Combined sources
Beta strandi18 – 203Combined sources
Helixi23 – 253Combined sources
Beta strandi26 – 283Combined sources
Helixi32 – 4413Combined sources
Beta strandi47 – 559Combined sources
Helixi61 – 7616Combined sources
Beta strandi81 – 877Combined sources
Helixi90 – 923Combined sources
Helixi104 – 11512Combined sources
Beta strandi124 – 1274Combined sources
Beta strandi129 – 1324Combined sources
Helixi133 – 1353Combined sources
Beta strandi142 – 1454Combined sources
Beta strandi148 – 1536Combined sources
Turni158 – 1625Combined sources
Beta strandi172 – 1765Combined sources
Helixi178 – 19013Combined sources
Turni195 – 1973Combined sources
Beta strandi199 – 2046Combined sources
Helixi209 – 2113Combined sources
Helixi213 – 22614Combined sources
Beta strandi235 – 2373Combined sources
Beta strandi242 – 25312Combined sources
Helixi255 – 26511Combined sources
Beta strandi268 – 2747Combined sources
Beta strandi276 – 2783Combined sources
Helixi282 – 29211Combined sources
Turni293 – 2953Combined sources
Beta strandi297 – 3037Combined sources
Helixi305 – 3073Combined sources
Helixi320 – 3234Combined sources
Helixi324 – 33815Combined sources
Helixi340 – 3456Combined sources
Beta strandi346 – 3538Combined sources
Beta strandi358 – 3603Combined sources
Beta strandi364 – 3674Combined sources
Turni368 – 3703Combined sources
Beta strandi371 – 3755Combined sources
Helixi381 – 3855Combined sources
Beta strandi388 – 3958Combined sources
Helixi402 – 41312Combined sources
Beta strandi416 – 4183Combined sources
Helixi422 – 4243Combined sources
Helixi428 – 4303Combined sources
Helixi433 – 44412Combined sources
Helixi447 – 4548Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HSIX-ray2.20A/B/C1-455[»]
ProteinModelPortaliP44704.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP44704.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini134 – 16027PLD phosphodiesterase 1PROSITE-ProRule annotationAdd
BLAST
Domaini356 – 38328PLD phosphodiesterase 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 PLD phosphodiesterase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105JIM. Bacteria.
COG1502. LUCA.
KOiK00998.
OMAiHLKGFVI.
PhylomeDBiP44704.

Family and domain databases

InterProiIPR025202. PLD-like_dom.
IPR016270. PLipase-D_PtdSer-synthase-type.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PANTHERiPTHR12586. PTHR12586. 1 hit.
PfamiPF13091. PLDc_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000850. Phospholipase_D_PSS. 1 hit.
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
PROSITEiPS50035. PLD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44704-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLINKTKRAE QNLNNLPFLA LQAEQIEFLG SSAEFKTQII ELIRNAKKRI
60 70 80 90 100
YVTALYWQKD EAGQEILDEI YRVKQENPHL DVKVLIDWHR AQRNLLGAEK
110 120 130 140 150
SATNADWYCE QRQTYQLPDD PNMFFGVPIN TREVFGVLHV KGFVFDDTVL
160 170 180 190 200
YSGASINNVY LHQFEKYRYD RYQKITHAEL ADSMVNFIND YLLDFSAVYP
210 220 230 240 250
LDVTNRPRTK EIRGNIRAYR KDLAQNGEYS LKSAVKLPNV LSVSPLFGLG
260 270 280 290 300
ASGNELNQVI EDLFLQVQKK LVICTPYFNF PRTLQHKIAT LLENGKRVEI
310 320 330 340 350
IVGDKVANDF YIPPEQPFKM AGALPYLYES NLRRFCEKFE TQIESGQLVV
360 370 380 390 400
RLWRDGDNTY HLKGVWVDDR YILLTGNNLN PRAWRLDAEN GLLIYDPQQQ
410 420 430 440 450
LLAQVEKEQN QIRQHTKVLK HYTELEELNQ YPEPVQKLLK KFARIKADKL

VKMIL
Length:455
Mass (Da):53,080
Last modified:November 1, 1995 - v1
Checksum:i255CA66C1C45B9EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22084.1.
PIRiI64066.
RefSeqiNP_438586.1. NC_000907.1.
WP_005693739.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22084; AAC22084; HI_0425.
GeneIDi950510.
KEGGihin:HI0425.
PATRICi20189403. VBIHaeInf48452_0445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22084.1.
PIRiI64066.
RefSeqiNP_438586.1. NC_000907.1.
WP_005693739.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HSIX-ray2.20A/B/C1-455[»]
ProteinModelPortaliP44704.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0425.

Protocols and materials databases

DNASUi950510.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22084; AAC22084; HI_0425.
GeneIDi950510.
KEGGihin:HI0425.
PATRICi20189403. VBIHaeInf48452_0445.

Phylogenomic databases

eggNOGiENOG4105JIM. Bacteria.
COG1502. LUCA.
KOiK00998.
OMAiHLKGFVI.
PhylomeDBiP44704.

Miscellaneous databases

EvolutionaryTraceiP44704.

Family and domain databases

InterProiIPR025202. PLD-like_dom.
IPR016270. PLipase-D_PtdSer-synthase-type.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PANTHERiPTHR12586. PTHR12586. 1 hit.
PfamiPF13091. PLDc_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000850. Phospholipase_D_PSS. 1 hit.
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
PROSITEiPS50035. PLD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSS_HAEIN
AccessioniPrimary (citable) accession number: P44704
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.