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Protein

CDP-diacylglycerol--serine O-phosphatidyltransferase

Gene

pssA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

CDP-diacylglycerol + L-serine = CMP + (3-sn-phosphatidyl)-L-serine.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-diacylglycerol--serine O-phosphatidyltransferase (EC:2.7.8.8)
Alternative name(s):
Phosphatidylserine synthase
Gene namesi
Name:pssA
Ordered Locus Names:HI_0425
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000568251 – 455CDP-diacylglycerol--serine O-phosphatidyltransferaseAdd BLAST455

Interactioni

Subunit structurei

Multimeric.

Protein-protein interaction databases

STRINGi71421.HI0425.

Structurei

Secondary structure

1455
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 14Combined sources10
Beta strandi18 – 20Combined sources3
Helixi23 – 25Combined sources3
Beta strandi26 – 28Combined sources3
Helixi32 – 44Combined sources13
Beta strandi47 – 55Combined sources9
Helixi61 – 76Combined sources16
Beta strandi81 – 87Combined sources7
Helixi90 – 92Combined sources3
Helixi104 – 115Combined sources12
Beta strandi124 – 127Combined sources4
Beta strandi129 – 132Combined sources4
Helixi133 – 135Combined sources3
Beta strandi142 – 145Combined sources4
Beta strandi148 – 153Combined sources6
Turni158 – 162Combined sources5
Beta strandi172 – 176Combined sources5
Helixi178 – 190Combined sources13
Turni195 – 197Combined sources3
Beta strandi199 – 204Combined sources6
Helixi209 – 211Combined sources3
Helixi213 – 226Combined sources14
Beta strandi235 – 237Combined sources3
Beta strandi242 – 253Combined sources12
Helixi255 – 265Combined sources11
Beta strandi268 – 274Combined sources7
Beta strandi276 – 278Combined sources3
Helixi282 – 292Combined sources11
Turni293 – 295Combined sources3
Beta strandi297 – 303Combined sources7
Helixi305 – 307Combined sources3
Helixi320 – 323Combined sources4
Helixi324 – 338Combined sources15
Helixi340 – 345Combined sources6
Beta strandi346 – 353Combined sources8
Beta strandi358 – 360Combined sources3
Beta strandi364 – 367Combined sources4
Turni368 – 370Combined sources3
Beta strandi371 – 375Combined sources5
Helixi381 – 385Combined sources5
Beta strandi388 – 395Combined sources8
Helixi402 – 413Combined sources12
Beta strandi416 – 418Combined sources3
Helixi422 – 424Combined sources3
Helixi428 – 430Combined sources3
Helixi433 – 444Combined sources12
Helixi447 – 454Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HSIX-ray2.20A/B/C1-455[»]
ProteinModelPortaliP44704.
SMRiP44704.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP44704.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 160PLD phosphodiesterase 1PROSITE-ProRule annotationAdd BLAST27
Domaini356 – 383PLD phosphodiesterase 2PROSITE-ProRule annotationAdd BLAST28

Sequence similaritiesi

Contains 2 PLD phosphodiesterase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105JIM. Bacteria.
COG1502. LUCA.
KOiK00998.
OMAiHLKGFVI.
PhylomeDBiP44704.

Family and domain databases

InterProiIPR025202. PLD-like_dom.
IPR016270. PLipase-D_PtdSer-synthase-type.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PANTHERiPTHR12586. PTHR12586. 1 hit.
PfamiPF13091. PLDc_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000850. Phospholipase_D_PSS. 1 hit.
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
PROSITEiPS50035. PLD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44704-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLINKTKRAE QNLNNLPFLA LQAEQIEFLG SSAEFKTQII ELIRNAKKRI
60 70 80 90 100
YVTALYWQKD EAGQEILDEI YRVKQENPHL DVKVLIDWHR AQRNLLGAEK
110 120 130 140 150
SATNADWYCE QRQTYQLPDD PNMFFGVPIN TREVFGVLHV KGFVFDDTVL
160 170 180 190 200
YSGASINNVY LHQFEKYRYD RYQKITHAEL ADSMVNFIND YLLDFSAVYP
210 220 230 240 250
LDVTNRPRTK EIRGNIRAYR KDLAQNGEYS LKSAVKLPNV LSVSPLFGLG
260 270 280 290 300
ASGNELNQVI EDLFLQVQKK LVICTPYFNF PRTLQHKIAT LLENGKRVEI
310 320 330 340 350
IVGDKVANDF YIPPEQPFKM AGALPYLYES NLRRFCEKFE TQIESGQLVV
360 370 380 390 400
RLWRDGDNTY HLKGVWVDDR YILLTGNNLN PRAWRLDAEN GLLIYDPQQQ
410 420 430 440 450
LLAQVEKEQN QIRQHTKVLK HYTELEELNQ YPEPVQKLLK KFARIKADKL

VKMIL
Length:455
Mass (Da):53,080
Last modified:November 1, 1995 - v1
Checksum:i255CA66C1C45B9EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22084.1.
PIRiI64066.
RefSeqiNP_438586.1. NC_000907.1.
WP_005693739.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22084; AAC22084; HI_0425.
GeneIDi950510.
KEGGihin:HI0425.
PATRICi20189403. VBIHaeInf48452_0445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22084.1.
PIRiI64066.
RefSeqiNP_438586.1. NC_000907.1.
WP_005693739.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HSIX-ray2.20A/B/C1-455[»]
ProteinModelPortaliP44704.
SMRiP44704.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0425.

Protocols and materials databases

DNASUi950510.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22084; AAC22084; HI_0425.
GeneIDi950510.
KEGGihin:HI0425.
PATRICi20189403. VBIHaeInf48452_0445.

Phylogenomic databases

eggNOGiENOG4105JIM. Bacteria.
COG1502. LUCA.
KOiK00998.
OMAiHLKGFVI.
PhylomeDBiP44704.

Miscellaneous databases

EvolutionaryTraceiP44704.

Family and domain databases

InterProiIPR025202. PLD-like_dom.
IPR016270. PLipase-D_PtdSer-synthase-type.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PANTHERiPTHR12586. PTHR12586. 1 hit.
PfamiPF13091. PLDc_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000850. Phospholipase_D_PSS. 1 hit.
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
PROSITEiPS50035. PLD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSS_HAEIN
AccessioniPrimary (citable) accession number: P44704
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.