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P44697 (THID_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

EC=2.7.1.49
EC=2.7.4.7
Alternative name(s):
Hydroxymethylpyrimidine kinase
Short name=HMP kinase
Hydroxymethylpyrimidine phosphate kinase
Short name=HMP-P kinase
Short name=HMP-phosphate kinase
Short name=HMPP kinase
Gene names
Name:thiD
Ordered Locus Names:HI_0416
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P By similarity.

Catalytic activity

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.

ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 2/3.

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.

Sequence similarities

Belongs to the ThiD family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
PRO_0000192019

Sites

Binding site451Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P44697 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 2B72DE9C39D1BEB3

FASTA26928,295
        10         20         30         40         50         60 
MSNVKQVLTI AGSDSGGGAG IQADLKTFQM RGVFGTSAIT AVTAQNTLGV FDIHPIPLKT 

        70         80         90        100        110        120 
IQAQLEAVKN DFQIASCKIG MLGNAEIIEC VADFLADKPF GTLVLDPVMI AKGGAPLLQR 

       130        140        150        160        170        180 
QAVSALSQKL LPLADVITPN IPEAEALTGI AIVDDISIQQ AAKALQKQGA KNVIIKGGHS 

       190        200        210        220        230        240 
LNSQSELCQD WVLLADGRHF TLQSPRFNTP HTHGTGCTFS ACLTAELAKG EPLQSAVKTA 

       250        260 
KDFITAAISH PLNIGQGHGP TNHWAYSRL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22074.1.
PIRI64151.
RefSeqNP_438578.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44697.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0416.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22074; AAC22074; HI_0416.
GeneID949517.
KEGGhin:HI0416.
PATRIC20189385. VBIHaeInf48452_0436.

Phylogenomic databases

eggNOGCOG0351.
KOK00941.
OMAFAFHCVH.
OrthoDBEOG6XWV53.
ProtClustDBPRK06427.

Enzyme and pathway databases

UniPathwayUPA00060; UER00137.
UPA00060; UER00138.

Family and domain databases

InterProIPR013749. HMP-P_kinase-1.
IPR004399. HMP-P_kinase-2.
[Graphical view]
PfamPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
TIGRFAMsTIGR00097. HMP-P_kinase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHID_HAEIN
AccessionPrimary (citable) accession number: P44697
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 13, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names