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P44688

- MUTH_HAEIN

UniProt

P44688 - MUTH_HAEIN

Protein

DNA mismatch repair protein MutH

Gene

mutH

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.UniRule annotation

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. endonuclease activity Source: UniProtKB-KW

    GO - Biological processi

    1. DNA modification Source: InterPro
    2. DNA repair Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    DNA damage, DNA repair

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA mismatch repair protein MutHUniRule annotation
    Alternative name(s):
    Methyl-directed mismatch repair proteinUniRule annotation
    Gene namesi
    Name:mutHUniRule annotation
    Ordered Locus Names:HI_0403
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 223223DNA mismatch repair protein MutHPRO_0000198669Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0403.

    Structurei

    Secondary structure

    1
    223
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 1611
    Helixi21 – 277
    Helixi42 – 5110
    Beta strandi59 – 613
    Turni64 – 674
    Beta strandi68 – 758
    Beta strandi81 – 833
    Beta strandi85 – 895
    Helixi100 – 1023
    Helixi104 – 1096
    Beta strandi110 – 1189
    Helixi125 – 1273
    Beta strandi134 – 1363
    Helixi140 – 15819
    Helixi162 – 1643
    Beta strandi171 – 1777
    Beta strandi179 – 1813
    Beta strandi186 – 1894
    Beta strandi195 – 1984
    Beta strandi201 – 2055
    Helixi207 – 21812

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2AOQX-ray2.20A1-223[»]
    2AORX-ray2.00A/B1-223[»]
    ProteinModelPortaliP44688.
    SMRiP44688. Positions 1-221.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP44688.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MutH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3066.
    KOiK03573.
    OMAiLRPKGAN.
    OrthoDBiEOG6CGCC0.
    PhylomeDBiP44688.

    Family and domain databases

    Gene3Di3.40.600.10. 1 hit.
    HAMAPiMF_00759. MutH.
    InterProiIPR004230. DNA_mismatch_repair_MutH.
    IPR011337. DNA_rep_MutH/RE_typeII.
    IPR011335. Restrct_endonuc-II-like.
    [Graphical view]
    PfamiPF02976. MutH. 1 hit.
    [Graphical view]
    SMARTiSM00927. MutH. 1 hit.
    [Graphical view]
    SUPFAMiSSF52980. SSF52980. 1 hit.
    TIGRFAMsiTIGR02248. mutH_TIGR. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P44688-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIPQTLEQLL SQAQSIAGLT FGELADELHI PVPIDLKRDK GWVGMLLERA    50
    LGATAGSKAE QDFSHLGVEL KTLPINAEGY PLETTFVSLA PLVQNSGVKW 100
    ENSHVRHKLS CVLWMPIEGS RHIPLRERHI GAPIFWKPTA EQERQLKQDW 150
    EELMDLIVLG KLDQITARIG EVMQLRPKGA NSRAVTKGIG KNGEIIDTLP 200
    LGFYLRKEFT AQILNAFLET KSL 223
    Length:223
    Mass (Da):24,906
    Last modified:November 1, 1995 - v1
    Checksum:i339A4EF9DA0E622A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22062.1.
    PIRiH64065.
    RefSeqiNP_438565.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22062; AAC22062; HI_0403.
    GeneIDi949640.
    KEGGihin:HI0403.
    PATRICi20189357. VBIHaeInf48452_0422.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22062.1 .
    PIRi H64065.
    RefSeqi NP_438565.1. NC_000907.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2AOQ X-ray 2.20 A 1-223 [» ]
    2AOR X-ray 2.00 A/B 1-223 [» ]
    ProteinModelPortali P44688.
    SMRi P44688. Positions 1-221.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0403.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22062 ; AAC22062 ; HI_0403 .
    GeneIDi 949640.
    KEGGi hin:HI0403.
    PATRICi 20189357. VBIHaeInf48452_0422.

    Phylogenomic databases

    eggNOGi COG3066.
    KOi K03573.
    OMAi LRPKGAN.
    OrthoDBi EOG6CGCC0.
    PhylomeDBi P44688.

    Miscellaneous databases

    EvolutionaryTracei P44688.

    Family and domain databases

    Gene3Di 3.40.600.10. 1 hit.
    HAMAPi MF_00759. MutH.
    InterProi IPR004230. DNA_mismatch_repair_MutH.
    IPR011337. DNA_rep_MutH/RE_typeII.
    IPR011335. Restrct_endonuc-II-like.
    [Graphical view ]
    Pfami PF02976. MutH. 1 hit.
    [Graphical view ]
    SMARTi SM00927. MutH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52980. SSF52980. 1 hit.
    TIGRFAMsi TIGR02248. mutH_TIGR. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiMUTH_HAEIN
    AccessioniPrimary (citable) accession number: P44688
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3