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Protein

DNA mismatch repair protein MutH

Gene

mutH

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutHUniRule annotation
Alternative name(s):
Methyl-directed mismatch repair proteinUniRule annotation
Gene namesi
Name:mutHUniRule annotation
Ordered Locus Names:HI_0403
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001986691 – 223DNA mismatch repair protein MutHAdd BLAST223

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0403.

Structurei

Secondary structure

1223
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 16Combined sources11
Helixi21 – 27Combined sources7
Helixi42 – 51Combined sources10
Beta strandi59 – 61Combined sources3
Turni64 – 67Combined sources4
Beta strandi68 – 75Combined sources8
Beta strandi81 – 83Combined sources3
Beta strandi85 – 89Combined sources5
Helixi100 – 102Combined sources3
Helixi104 – 109Combined sources6
Beta strandi110 – 118Combined sources9
Helixi125 – 127Combined sources3
Beta strandi134 – 136Combined sources3
Helixi140 – 158Combined sources19
Helixi162 – 164Combined sources3
Beta strandi171 – 177Combined sources7
Beta strandi179 – 181Combined sources3
Beta strandi186 – 189Combined sources4
Beta strandi195 – 198Combined sources4
Beta strandi201 – 205Combined sources5
Helixi207 – 218Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AOQX-ray2.20A1-223[»]
2AORX-ray2.00A/B1-223[»]
ProteinModelPortaliP44688.
SMRiP44688.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP44688.

Family & Domainsi

Sequence similaritiesi

Belongs to the MutH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105IRT. Bacteria.
COG3066. LUCA.
KOiK03573.
OMAiVMQLRPK.
PhylomeDBiP44688.

Family and domain databases

CDDicd00583. MutH_Sau3AI. 1 hit.
Gene3Di3.40.600.10. 1 hit.
HAMAPiMF_00759. MutH. 1 hit.
InterProiIPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamiPF02976. MutH. 1 hit.
[Graphical view]
SMARTiSM00927. MutH. 1 hit.
[Graphical view]
SUPFAMiSSF52980. SSF52980. 1 hit.
TIGRFAMsiTIGR02248. mutH_TIGR. 1 hit.

Sequencei

Sequence statusi: Complete.

P44688-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPQTLEQLL SQAQSIAGLT FGELADELHI PVPIDLKRDK GWVGMLLERA
60 70 80 90 100
LGATAGSKAE QDFSHLGVEL KTLPINAEGY PLETTFVSLA PLVQNSGVKW
110 120 130 140 150
ENSHVRHKLS CVLWMPIEGS RHIPLRERHI GAPIFWKPTA EQERQLKQDW
160 170 180 190 200
EELMDLIVLG KLDQITARIG EVMQLRPKGA NSRAVTKGIG KNGEIIDTLP
210 220
LGFYLRKEFT AQILNAFLET KSL
Length:223
Mass (Da):24,906
Last modified:November 1, 1995 - v1
Checksum:i339A4EF9DA0E622A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22062.1.
PIRiH64065.
RefSeqiNP_438565.1. NC_000907.1.
WP_005693765.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22062; AAC22062; HI_0403.
GeneIDi949640.
KEGGihin:HI0403.
PATRICi20189357. VBIHaeInf48452_0422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22062.1.
PIRiH64065.
RefSeqiNP_438565.1. NC_000907.1.
WP_005693765.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AOQX-ray2.20A1-223[»]
2AORX-ray2.00A/B1-223[»]
ProteinModelPortaliP44688.
SMRiP44688.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0403.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22062; AAC22062; HI_0403.
GeneIDi949640.
KEGGihin:HI0403.
PATRICi20189357. VBIHaeInf48452_0422.

Phylogenomic databases

eggNOGiENOG4105IRT. Bacteria.
COG3066. LUCA.
KOiK03573.
OMAiVMQLRPK.
PhylomeDBiP44688.

Miscellaneous databases

EvolutionaryTraceiP44688.

Family and domain databases

CDDicd00583. MutH_Sau3AI. 1 hit.
Gene3Di3.40.600.10. 1 hit.
HAMAPiMF_00759. MutH. 1 hit.
InterProiIPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamiPF02976. MutH. 1 hit.
[Graphical view]
SMARTiSM00927. MutH. 1 hit.
[Graphical view]
SUPFAMiSSF52980. SSF52980. 1 hit.
TIGRFAMsiTIGR02248. mutH_TIGR. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMUTH_HAEIN
AccessioniPrimary (citable) accession number: P44688
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.