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P44688

- MUTH_HAEIN

UniProt

P44688 - MUTH_HAEIN

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Protein

DNA mismatch repair protein MutH

Gene

mutH

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. endonuclease activity Source: UniProtKB-KW

GO - Biological processi

  1. DNA modification Source: InterPro
  2. DNA repair Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutHUniRule annotation
Alternative name(s):
Methyl-directed mismatch repair proteinUniRule annotation
Gene namesi
Name:mutHUniRule annotation
Ordered Locus Names:HI_0403
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223DNA mismatch repair protein MutHPRO_0000198669Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0403.

Structurei

Secondary structure

1
223
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 1611
Helixi21 – 277
Helixi42 – 5110
Beta strandi59 – 613
Turni64 – 674
Beta strandi68 – 758
Beta strandi81 – 833
Beta strandi85 – 895
Helixi100 – 1023
Helixi104 – 1096
Beta strandi110 – 1189
Helixi125 – 1273
Beta strandi134 – 1363
Helixi140 – 15819
Helixi162 – 1643
Beta strandi171 – 1777
Beta strandi179 – 1813
Beta strandi186 – 1894
Beta strandi195 – 1984
Beta strandi201 – 2055
Helixi207 – 21812

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AOQX-ray2.20A1-223[»]
2AORX-ray2.00A/B1-223[»]
ProteinModelPortaliP44688.
SMRiP44688. Positions 1-221.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP44688.

Family & Domainsi

Sequence similaritiesi

Belongs to the MutH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3066.
KOiK03573.
OMAiLRPKGAN.
OrthoDBiEOG6CGCC0.
PhylomeDBiP44688.

Family and domain databases

Gene3Di3.40.600.10. 1 hit.
HAMAPiMF_00759. MutH.
InterProiIPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamiPF02976. MutH. 1 hit.
[Graphical view]
SMARTiSM00927. MutH. 1 hit.
[Graphical view]
SUPFAMiSSF52980. SSF52980. 1 hit.
TIGRFAMsiTIGR02248. mutH_TIGR. 1 hit.

Sequencei

Sequence statusi: Complete.

P44688 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIPQTLEQLL SQAQSIAGLT FGELADELHI PVPIDLKRDK GWVGMLLERA
60 70 80 90 100
LGATAGSKAE QDFSHLGVEL KTLPINAEGY PLETTFVSLA PLVQNSGVKW
110 120 130 140 150
ENSHVRHKLS CVLWMPIEGS RHIPLRERHI GAPIFWKPTA EQERQLKQDW
160 170 180 190 200
EELMDLIVLG KLDQITARIG EVMQLRPKGA NSRAVTKGIG KNGEIIDTLP
210 220
LGFYLRKEFT AQILNAFLET KSL
Length:223
Mass (Da):24,906
Last modified:November 1, 1995 - v1
Checksum:i339A4EF9DA0E622A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22062.1.
PIRiH64065.
RefSeqiNP_438565.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22062; AAC22062; HI_0403.
GeneIDi949640.
KEGGihin:HI0403.
PATRICi20189357. VBIHaeInf48452_0422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22062.1 .
PIRi H64065.
RefSeqi NP_438565.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2AOQ X-ray 2.20 A 1-223 [» ]
2AOR X-ray 2.00 A/B 1-223 [» ]
ProteinModelPortali P44688.
SMRi P44688. Positions 1-221.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0403.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22062 ; AAC22062 ; HI_0403 .
GeneIDi 949640.
KEGGi hin:HI0403.
PATRICi 20189357. VBIHaeInf48452_0422.

Phylogenomic databases

eggNOGi COG3066.
KOi K03573.
OMAi LRPKGAN.
OrthoDBi EOG6CGCC0.
PhylomeDBi P44688.

Miscellaneous databases

EvolutionaryTracei P44688.

Family and domain databases

Gene3Di 3.40.600.10. 1 hit.
HAMAPi MF_00759. MutH.
InterProi IPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view ]
Pfami PF02976. MutH. 1 hit.
[Graphical view ]
SMARTi SM00927. MutH. 1 hit.
[Graphical view ]
SUPFAMi SSF52980. SSF52980. 1 hit.
TIGRFAMsi TIGR02248. mutH_TIGR. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiMUTH_HAEIN
AccessioniPrimary (citable) accession number: P44688
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3