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P44688 (MUTH_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA mismatch repair protein MutH
Alternative name(s):
Methyl-directed mismatch repair protein
Gene names
Name:mutH
Ordered Locus Names:HI_0403
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair By similarity. HAMAP-Rule MF_00759

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00759.

Sequence similarities

Belongs to the MutH family.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   Cellular componentCytoplasm
   Molecular functionEndonuclease
Hydrolase
Nuclease
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA modification

Inferred from electronic annotation. Source: InterPro

DNA repair

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: InterPro

endonuclease activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 223223DNA mismatch repair protein MutH HAMAP-Rule MF_00759
PRO_0000198669

Secondary structure

......................................... 223
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P44688 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 339A4EF9DA0E622A

FASTA22324,906
        10         20         30         40         50         60 
MIPQTLEQLL SQAQSIAGLT FGELADELHI PVPIDLKRDK GWVGMLLERA LGATAGSKAE 

        70         80         90        100        110        120 
QDFSHLGVEL KTLPINAEGY PLETTFVSLA PLVQNSGVKW ENSHVRHKLS CVLWMPIEGS 

       130        140        150        160        170        180 
RHIPLRERHI GAPIFWKPTA EQERQLKQDW EELMDLIVLG KLDQITARIG EVMQLRPKGA 

       190        200        210        220 
NSRAVTKGIG KNGEIIDTLP LGFYLRKEFT AQILNAFLET KSL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22062.1.
PIRH64065.
RefSeqNP_438565.1. NC_000907.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2AOQX-ray2.20A1-223[»]
2AORX-ray2.00A/B1-223[»]
ProteinModelPortalP44688.
SMRP44688. Positions 1-221.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0403.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22062; AAC22062; HI_0403.
GeneID949640.
KEGGhin:HI0403.
PATRIC20189357. VBIHaeInf48452_0422.

Phylogenomic databases

eggNOGCOG3066.
KOK03573.
OMALRPKGAN.
OrthoDBEOG6CGCC0.
PhylomeDBP44688.

Family and domain databases

Gene3D3.40.600.10. 1 hit.
HAMAPMF_00759. MutH.
InterProIPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamPF02976. MutH. 1 hit.
[Graphical view]
SMARTSM00927. MutH. 1 hit.
[Graphical view]
SUPFAMSSF52980. SSF52980. 1 hit.
TIGRFAMsTIGR02248. mutH_TIGR. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP44688.

Entry information

Entry nameMUTH_HAEIN
AccessionPrimary (citable) accession number: P44688
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names