SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P44685

- CPDA_HAEIN

UniProt

P44685 - CPDA_HAEIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA
Gene
cpdA, icc, HI_0399
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. May coordinate responses to nutritional stress, ensuring optimal competence development.1 Publication

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

Binds 2 metal cations per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi21 – 211Metal cation 1 By similarity
Metal bindingi23 – 231Metal cation 1 By similarity
Binding sitei23 – 231cAMP By similarity
Metal bindingi63 – 631Metal cation 1 By similarity
Metal bindingi63 – 631Metal cation 2 By similarity
Binding sitei63 – 631cAMP By similarity
Metal bindingi93 – 931Metal cation 2 By similarity
Metal bindingi163 – 1631Metal cation 2 By similarity
Metal bindingi202 – 2021Metal cation 2 By similarity
Metal bindingi204 – 2041Metal cation 1 By similarity
Binding sitei204 – 2041cAMP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi93 – 942cAMP By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA (EC:3.1.4.17)
Short name:
3',5'-cyclic AMP phosphodiesterase
Short name:
cAMP phosphodiesterase
Gene namesi
Name:cpdA
Synonyms:icc
Ordered Locus Names:HI_0399
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Pathology & Biotechi

Disruption phenotypei

Mutants show increased levels of cellular cAMP.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2742743',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation
PRO_0000084148Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0399.

Structurei

3D structure databases

ProteinModelPortaliP44685.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1409.
KOiK03651.
OMAiWREIELH.
OrthoDBiEOG6QG8GQ.
PhylomeDBiP44685.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR013622. Calcineurin-like_phos_C.
IPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
ProDomiPD587589. Calcineurin-like_phos_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

P44685-1 [UniParc]FASTAAdd to Basket

« Hide

MKNTFVYQAE KPVIKLLQIT DPHLFKDESA ELLGVNTQAS FAQVLKEIQQ    50
ENNEFDVILA TGDLVQDSSD EGYIRFVEMM KPFNKPVFWI PGNHDFQPKM 100
AEFLNQPPMN AAKHLLLGEH WQALLLDSQV YGVPHGQLSQ HQLDLLKETL 150
GKNPERYTLV VLHHHLLPTN SAWLDQHNLR NSHELAEVLA PFTNVKAILY 200
GHIHQEVNSE WNGYQVMATP ATCIQFKPDC QYFSLDTLQP GWREIELHSD 250
GSIRTEVKRI QQAEFFPNMQ EEGY 274
Length:274
Mass (Da):31,556
Last modified:November 1, 1995 - v1
Checksum:iA810BF2072CA4957
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22058.1.
PIRiE64065.
RefSeqiNP_438561.1. NC_000907.1.
WP_005693770.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22058; AAC22058; HI_0399.
GeneIDi949501.
KEGGihin:HI0399.
PATRICi20189349. VBIHaeInf48452_0418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22058.1 .
PIRi E64065.
RefSeqi NP_438561.1. NC_000907.1.
WP_005693770.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44685.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0399.

Protocols and materials databases

DNASUi 949501.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22058 ; AAC22058 ; HI_0399 .
GeneIDi 949501.
KEGGi hin:HI0399.
PATRICi 20189349. VBIHaeInf48452_0418.

Phylogenomic databases

eggNOGi COG1409.
KOi K03651.
OMAi WREIELH.
OrthoDBi EOG6QG8GQ.
PhylomeDBi P44685.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR013622. Calcineurin-like_phos_C.
IPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
ProDomi PD587589. Calcineurin-like_phos_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. "A 3',5' cyclic AMP (cAMP) phosphodiesterase modulates cAMP levels and optimizes competence in Haemophilus influenzae Rd."
    Macfadyen L.P., Ma C., Redfield R.J.
    J. Bacteriol. 180:4401-4405(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiCPDA_HAEIN
AccessioniPrimary (citable) accession number: P44685
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi