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P44685

- CPDA_HAEIN

UniProt

P44685 - CPDA_HAEIN

Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. May coordinate responses to nutritional stress, ensuring optimal competence development.1 PublicationUniRule annotation

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

    Cofactori

    Binds 2 metal cations per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi21 – 211Metal cation 1UniRule annotation
    Metal bindingi23 – 231Metal cation 1UniRule annotation
    Binding sitei23 – 231cAMPUniRule annotation
    Metal bindingi63 – 631Metal cation 1UniRule annotation
    Metal bindingi63 – 631Metal cation 2UniRule annotation
    Binding sitei63 – 631cAMPUniRule annotation
    Metal bindingi93 – 931Metal cation 2UniRule annotation
    Metal bindingi163 – 1631Metal cation 2UniRule annotation
    Metal bindingi202 – 2021Metal cation 2UniRule annotation
    Metal bindingi204 – 2041Metal cation 1UniRule annotation
    Binding sitei204 – 2041cAMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi93 – 942cAMPUniRule annotation

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP
    3. nucleotide binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
    Short name:
    3',5'-cyclic AMP phosphodiesteraseUniRule annotation
    Short name:
    cAMP phosphodiesteraseUniRule annotation
    Gene namesi
    Name:cpdAUniRule annotation
    Synonyms:icc
    Ordered Locus Names:HI_0399
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Pathology & Biotechi

    Disruption phenotypei

    Mutants show increased levels of cellular cAMP.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2742743',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000084148Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0399.

    Structurei

    3D structure databases

    ProteinModelPortaliP44685.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1409.
    KOiK03651.
    OMAiWREIELH.
    OrthoDBiEOG6QG8GQ.
    PhylomeDBiP44685.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    HAMAPiMF_00905. cAMP_phophodiest_CpdA.
    InterProiIPR013622. Calcineurin-like_phos_C.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    ProDomiPD587589. Calcineurin-like_phos_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P44685-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNTFVYQAE KPVIKLLQIT DPHLFKDESA ELLGVNTQAS FAQVLKEIQQ    50
    ENNEFDVILA TGDLVQDSSD EGYIRFVEMM KPFNKPVFWI PGNHDFQPKM 100
    AEFLNQPPMN AAKHLLLGEH WQALLLDSQV YGVPHGQLSQ HQLDLLKETL 150
    GKNPERYTLV VLHHHLLPTN SAWLDQHNLR NSHELAEVLA PFTNVKAILY 200
    GHIHQEVNSE WNGYQVMATP ATCIQFKPDC QYFSLDTLQP GWREIELHSD 250
    GSIRTEVKRI QQAEFFPNMQ EEGY 274
    Length:274
    Mass (Da):31,556
    Last modified:November 1, 1995 - v1
    Checksum:iA810BF2072CA4957
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22058.1.
    PIRiE64065.
    RefSeqiNP_438561.1. NC_000907.1.
    WP_005693770.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22058; AAC22058; HI_0399.
    GeneIDi949501.
    KEGGihin:HI0399.
    PATRICi20189349. VBIHaeInf48452_0418.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22058.1 .
    PIRi E64065.
    RefSeqi NP_438561.1. NC_000907.1.
    WP_005693770.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44685.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0399.

    Protocols and materials databases

    DNASUi 949501.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22058 ; AAC22058 ; HI_0399 .
    GeneIDi 949501.
    KEGGi hin:HI0399.
    PATRICi 20189349. VBIHaeInf48452_0418.

    Phylogenomic databases

    eggNOGi COG1409.
    KOi K03651.
    OMAi WREIELH.
    OrthoDBi EOG6QG8GQ.
    PhylomeDBi P44685.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    HAMAPi MF_00905. cAMP_phophodiest_CpdA.
    InterProi IPR013622. Calcineurin-like_phos_C.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    ProDomi PD587589. Calcineurin-like_phos_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
    2. "A 3',5' cyclic AMP (cAMP) phosphodiesterase modulates cAMP levels and optimizes competence in Haemophilus influenzae Rd."
      Macfadyen L.P., Ma C., Redfield R.J.
      J. Bacteriol. 180:4401-4405(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiCPDA_HAEIN
    AccessioniPrimary (citable) accession number: P44685
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3