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P44685

- CPDA_HAEIN

UniProt

P44685 - CPDA_HAEIN

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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. May coordinate responses to nutritional stress, ensuring optimal competence development.1 PublicationUniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi21 – 211Metal cation 1UniRule annotation
Metal bindingi23 – 231Metal cation 1UniRule annotation
Binding sitei23 – 231cAMPUniRule annotation
Metal bindingi63 – 631Metal cation 1UniRule annotation
Metal bindingi63 – 631Metal cation 2UniRule annotation
Binding sitei63 – 631cAMPUniRule annotation
Metal bindingi93 – 931Metal cation 2UniRule annotation
Metal bindingi163 – 1631Metal cation 2UniRule annotation
Metal bindingi202 – 2021Metal cation 2UniRule annotation
Metal bindingi204 – 2041Metal cation 1UniRule annotation
Binding sitei204 – 2041cAMPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi93 – 942cAMPUniRule annotation

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Synonyms:icc
Ordered Locus Names:HI_0399
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Pathology & Biotechi

Disruption phenotypei

Mutants show increased levels of cellular cAMP.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2742743',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000084148Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0399.

Structurei

3D structure databases

ProteinModelPortaliP44685.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1409.
KOiK03651.
OMAiWREIELH.
OrthoDBiEOG6QG8GQ.
PhylomeDBiP44685.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR013622. Calcineurin-like_phos_C.
IPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
ProDomiPD587589. Calcineurin-like_phos_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

P44685-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNTFVYQAE KPVIKLLQIT DPHLFKDESA ELLGVNTQAS FAQVLKEIQQ
60 70 80 90 100
ENNEFDVILA TGDLVQDSSD EGYIRFVEMM KPFNKPVFWI PGNHDFQPKM
110 120 130 140 150
AEFLNQPPMN AAKHLLLGEH WQALLLDSQV YGVPHGQLSQ HQLDLLKETL
160 170 180 190 200
GKNPERYTLV VLHHHLLPTN SAWLDQHNLR NSHELAEVLA PFTNVKAILY
210 220 230 240 250
GHIHQEVNSE WNGYQVMATP ATCIQFKPDC QYFSLDTLQP GWREIELHSD
260 270
GSIRTEVKRI QQAEFFPNMQ EEGY
Length:274
Mass (Da):31,556
Last modified:November 1, 1995 - v1
Checksum:iA810BF2072CA4957
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22058.1.
PIRiE64065.
RefSeqiNP_438561.1. NC_000907.1.
WP_005693770.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22058; AAC22058; HI_0399.
GeneIDi949501.
KEGGihin:HI0399.
PATRICi20189349. VBIHaeInf48452_0418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22058.1 .
PIRi E64065.
RefSeqi NP_438561.1. NC_000907.1.
WP_005693770.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44685.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0399.

Protocols and materials databases

DNASUi 949501.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22058 ; AAC22058 ; HI_0399 .
GeneIDi 949501.
KEGGi hin:HI0399.
PATRICi 20189349. VBIHaeInf48452_0418.

Phylogenomic databases

eggNOGi COG1409.
KOi K03651.
OMAi WREIELH.
OrthoDBi EOG6QG8GQ.
PhylomeDBi P44685.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR013622. Calcineurin-like_phos_C.
IPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
ProDomi PD587589. Calcineurin-like_phos_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. "A 3',5' cyclic AMP (cAMP) phosphodiesterase modulates cAMP levels and optimizes competence in Haemophilus influenzae Rd."
    Macfadyen L.P., Ma C., Redfield R.J.
    J. Bacteriol. 180:4401-4405(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiCPDA_HAEIN
AccessioniPrimary (citable) accession number: P44685
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3