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P44680

- Y387_HAEIN

UniProt

P44680 - Y387_HAEIN

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Protein

Probable ATP-dependent helicase HI_0387

Gene

HI_0387

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi51 – 588ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP-dependent helicase activity Source: InterPro
  3. DNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent helicase HI_0387 (EC:3.6.4.12)
Gene namesi
Ordered Locus Names:HI_0387
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 640640Probable ATP-dependent helicase HI_0387PRO_0000102007Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0387.

Structurei

3D structure databases

ProteinModelPortaliP44680.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 278263Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini458 – 634177Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi231 – 2344DEAH box

Sequence similaritiesi

Belongs to the helicase family. DinG subfamily.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1199.
KOiK03722.
OMAiICDSRLV.
OrthoDBiEOG6742WF.
PhylomeDBiP44680.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR006555. ATP-dep_Helicase_C.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13307. Helicase_C_2. 1 hit.
PF04851. ResIII. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00491. HELICc2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 4 hits.
PROSITEiPS51193. HELICASE_ATP_BIND_2. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44680-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDYENQIANI FSLNGELSQN IKGFRPRAEQ LEMAYAVGKA IQNKSSLVIE
60 70 80 90 100
AGTGTGKTFA YLAPALVFGK KTIISTGSKN LQDQLFNRDL PAIKKALNFT
110 120 130 140 150
GKIALLKGRA NYLCLERLDQ VIAQGVLGDK SVLAELSKVR KWNNSTKTGD
160 170 180 190 200
FTECIELAED SPIIPQLTST AESCLGTDCP NYSECYVASA RKKALNADLV
210 220 230 240 250
VVNHHLFFAD MAVKESGFGE LIPNAEVIIF DEAHQLPDIA SQYFGQSLTS
260 270 280 290 300
RQLFDLCKDI NIVYRTELKD MQQLGTTSDT LLKVVQDFRL LLGNGSNVRG
310 320 330 340 350
NWRELYTQSA VKKAFELLQE KIDFLSEVIK LALGRSQTLD SIFERVESIK
360 370 380 390 400
IQLKRLSETN IVGYCYWYEG NGRQFGLHIT PLTVADKFGA QLEAKEAAWI
410 420 430 440 450
FTSATLEVGG TFNHFCQRLG IENATQKILY SPFNYPEQSL LCVPRYLPNT
460 470 480 490 500
NQMNTLNSLG EILLPVIEAN KGRCFVLCTS YSMMRGLAEY FREKSHLSIL
510 520 530 540 550
LQGETSKGKL LEQFIKETHS VLVATSSFWE GVDVRGDALS LVIIDKLPFT
560 570 580 590 600
APDEPLLKAR IEDCRLQGGD PFNDIQIPEA VITLKQGVGR LIRDVTDRGV
610 620 630 640
VIICDNRLVM RNYGETFLKS LPNSSRTRDL NKVIQFLQNK
Length:640
Mass (Da):71,531
Last modified:November 1, 1995 - v1
Checksum:iEC659D19C2F23D3C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22045.1.
PIRiA64065.
RefSeqiNP_438548.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22045; AAC22045; HI_0387.
GeneIDi949750.
KEGGihin:HI0387.
PATRICi20189323. VBIHaeInf48452_0405.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22045.1 .
PIRi A64065.
RefSeqi NP_438548.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44680.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0387.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22045 ; AAC22045 ; HI_0387 .
GeneIDi 949750.
KEGGi hin:HI0387.
PATRICi 20189323. VBIHaeInf48452_0405.

Phylogenomic databases

eggNOGi COG1199.
KOi K03722.
OMAi ICDSRLV.
OrthoDBi EOG6742WF.
PhylomeDBi P44680.

Family and domain databases

Gene3Di 3.40.50.300. 3 hits.
InterProi IPR006555. ATP-dep_Helicase_C.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF13307. Helicase_C_2. 1 hit.
PF04851. ResIII. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00491. HELICc2. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 4 hits.
PROSITEi PS51193. HELICASE_ATP_BIND_2. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiY387_HAEIN
AccessioniPrimary (citable) accession number: P44680
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3