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P44644

- RELA_HAEIN

UniProt

P44644 - RELA_HAEIN

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Protein

GTP pyrophosphokinase

Gene

relA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity).By similarity

Catalytic activityi

ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.

Pathwayi

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. GTP binding Source: UniProtKB-KW
  4. GTP diphosphokinase activity Source: UniProtKB-EC
  5. kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, GTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP pyrophosphokinase (EC:2.7.6.5)
Alternative name(s):
(p)ppGpp synthase
ATP:GTP 3'-pyrophosphotransferase
ppGpp synthase I
Gene namesi
Name:relA
Ordered Locus Names:HI_0334
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 743743GTP pyrophosphokinasePRO_0000166549Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0334.

Structurei

3D structure databases

ProteinModelPortaliP44644.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini670 – 74374ACTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RelA/SpoT family.Curated
Contains 1 ACT domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0317.
KOiK00951.
OMAiTEIGHNC.
OrthoDBiEOG6SV551.
PhylomeDBiP44644.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
SMARTiSM00954. RelA_SpoT. 1 hit.
[Graphical view]
SUPFAMiSSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00691. spoT_relA. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44644 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVAVRGSHLL NPQDFVIEQW CTGLKLAEQT EKSLIDAWYY ARDLMNAYPD
60 70 80 90 100
EMKNATLMLQ SGVEMVEILH ELNMDAETLL TAMLFPIVAN KLTDWESLKE
110 120 130 140 150
KFGAKITKLL KGVLEMDNIR QLNASHSANA LQVDNVRRML LAMVDDFRCV
160 170 180 190 200
IIKLAERITF LRDAEHRCAE EDKVLAVKEC SYIYAPLANR LGIGQLKWEL
210 220 230 240 250
EDYCFRYLHP EQYRAIAKLL QERRLDREHY IADFVSELSG YLRENIEQVE
260 270 280 290 300
VYGRPKHIYS IWRKMQKKHL EFSGLYDVRA VRIIVQKLQD CYTALGIVHT
310 320 330 340 350
QFKHLPKEFD DYVANPKPNG YQSIHTVVLG KGGKPIEVQI RTQQMHDDAE
360 370 380 390 400
LGMAAHWKYK EGNTGSMSAY EEKIAWLRKL LAWQDDITDS GEVLAELRSQ
410 420 430 440 450
VFDDRVYVFT PKGEVVDLPT GSTPLDFAYA IHSEIGHRCI GAKVAGRIVP
460 470 480 490 500
FTYQLQMGDQ IDIITQKNPN PSRDWLNPNL GFTHTAKSRA KIQAWFKKQD
510 520 530 540 550
RDKNIPAGKE LLDNELALLN LSIKQVEPYA LPRYNLKNLD DLYAGIGSGD
560 570 580 590 600
IRLNNLIHFL QSKLIKVTAE EADQEILRHV ANKSAVNSQQ KSEKNNGCVI
610 620 630 640 650
VEGVDNLMHH IARCCQPIPG DAIVGYITMG RGISIHRADC EQFLDLQAAH
660 670 680 690 700
PERVVESIWG ENYASGFHIN IRIVAGDRNG LLRDITTVLA NEKISVLGVS
710 720 730 740
SRADTKKQLA TIDMEIELHN VESLSKILAR LAKLDDVIEA KRL
Length:743
Mass (Da):84,567
Last modified:November 1, 1995 - v1
Checksum:i39B47619896AC211
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21996.1.
PIRiD64062.
RefSeqiNP_438498.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21996; AAC21996; HI_0334.
GeneIDi950822.
KEGGihin:HI0334.
PATRICi20189211. VBIHaeInf48452_0351.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21996.1 .
PIRi D64062.
RefSeqi NP_438498.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44644.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0334.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21996 ; AAC21996 ; HI_0334 .
GeneIDi 950822.
KEGGi hin:HI0334.
PATRICi 20189211. VBIHaeInf48452_0351.

Phylogenomic databases

eggNOGi COG0317.
KOi K00951.
OMAi TEIGHNC.
OrthoDBi EOG6SV551.
PhylomeDBi P44644.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view ]
Pfami PF01842. ACT. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view ]
SMARTi SM00954. RelA_SpoT. 1 hit.
[Graphical view ]
SUPFAMi SSF81271. SSF81271. 1 hit.
TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiRELA_HAEIN
AccessioniPrimary (citable) accession number: P44644
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3