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P44644

- RELA_HAEIN

UniProt

P44644 - RELA_HAEIN

Protein

GTP pyrophosphokinase

Gene

relA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp By similarity.By similarity

    Catalytic activityi

    ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.

    Pathwayi

    GO - Molecular functioni

    1. amino acid binding Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. GTP binding Source: UniProtKB-KW
    4. GTP diphosphokinase activity Source: UniProtKB-EC
    5. kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP pyrophosphokinase (EC:2.7.6.5)
    Alternative name(s):
    (p)ppGpp synthase
    ATP:GTP 3'-pyrophosphotransferase
    ppGpp synthase I
    Gene namesi
    Name:relA
    Ordered Locus Names:HI_0334
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 743743GTP pyrophosphokinasePRO_0000166549Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0334.

    Structurei

    3D structure databases

    ProteinModelPortaliP44644.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini670 – 74374ACTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RelA/SpoT family.Curated
    Contains 1 ACT domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0317.
    KOiK00951.
    OMAiTEIGHNC.
    OrthoDBiEOG6SV551.
    PhylomeDBiP44644.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR002912. ACT_dom.
    IPR012675. Beta-grasp_dom.
    IPR004811. RelA/Spo_fam.
    IPR007685. RelA_SpoT.
    IPR004095. TGS.
    IPR012676. TGS-like.
    [Graphical view]
    PfamiPF01842. ACT. 1 hit.
    PF04607. RelA_SpoT. 1 hit.
    PF02824. TGS. 1 hit.
    [Graphical view]
    SMARTiSM00954. RelA_SpoT. 1 hit.
    [Graphical view]
    SUPFAMiSSF81271. SSF81271. 1 hit.
    TIGRFAMsiTIGR00691. spoT_relA. 1 hit.
    PROSITEiPS51671. ACT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P44644-1 [UniParc]FASTAAdd to Basket

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    MVAVRGSHLL NPQDFVIEQW CTGLKLAEQT EKSLIDAWYY ARDLMNAYPD    50
    EMKNATLMLQ SGVEMVEILH ELNMDAETLL TAMLFPIVAN KLTDWESLKE 100
    KFGAKITKLL KGVLEMDNIR QLNASHSANA LQVDNVRRML LAMVDDFRCV 150
    IIKLAERITF LRDAEHRCAE EDKVLAVKEC SYIYAPLANR LGIGQLKWEL 200
    EDYCFRYLHP EQYRAIAKLL QERRLDREHY IADFVSELSG YLRENIEQVE 250
    VYGRPKHIYS IWRKMQKKHL EFSGLYDVRA VRIIVQKLQD CYTALGIVHT 300
    QFKHLPKEFD DYVANPKPNG YQSIHTVVLG KGGKPIEVQI RTQQMHDDAE 350
    LGMAAHWKYK EGNTGSMSAY EEKIAWLRKL LAWQDDITDS GEVLAELRSQ 400
    VFDDRVYVFT PKGEVVDLPT GSTPLDFAYA IHSEIGHRCI GAKVAGRIVP 450
    FTYQLQMGDQ IDIITQKNPN PSRDWLNPNL GFTHTAKSRA KIQAWFKKQD 500
    RDKNIPAGKE LLDNELALLN LSIKQVEPYA LPRYNLKNLD DLYAGIGSGD 550
    IRLNNLIHFL QSKLIKVTAE EADQEILRHV ANKSAVNSQQ KSEKNNGCVI 600
    VEGVDNLMHH IARCCQPIPG DAIVGYITMG RGISIHRADC EQFLDLQAAH 650
    PERVVESIWG ENYASGFHIN IRIVAGDRNG LLRDITTVLA NEKISVLGVS 700
    SRADTKKQLA TIDMEIELHN VESLSKILAR LAKLDDVIEA KRL 743
    Length:743
    Mass (Da):84,567
    Last modified:November 1, 1995 - v1
    Checksum:i39B47619896AC211
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21996.1.
    PIRiD64062.
    RefSeqiNP_438498.1. NC_000907.1.
    WP_005694339.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC21996; AAC21996; HI_0334.
    GeneIDi950822.
    KEGGihin:HI0334.
    PATRICi20189211. VBIHaeInf48452_0351.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21996.1 .
    PIRi D64062.
    RefSeqi NP_438498.1. NC_000907.1.
    WP_005694339.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44644.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0334.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC21996 ; AAC21996 ; HI_0334 .
    GeneIDi 950822.
    KEGGi hin:HI0334.
    PATRICi 20189211. VBIHaeInf48452_0351.

    Phylogenomic databases

    eggNOGi COG0317.
    KOi K00951.
    OMAi TEIGHNC.
    OrthoDBi EOG6SV551.
    PhylomeDBi P44644.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR002912. ACT_dom.
    IPR012675. Beta-grasp_dom.
    IPR004811. RelA/Spo_fam.
    IPR007685. RelA_SpoT.
    IPR004095. TGS.
    IPR012676. TGS-like.
    [Graphical view ]
    Pfami PF01842. ACT. 1 hit.
    PF04607. RelA_SpoT. 1 hit.
    PF02824. TGS. 1 hit.
    [Graphical view ]
    SMARTi SM00954. RelA_SpoT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81271. SSF81271. 1 hit.
    TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
    PROSITEi PS51671. ACT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiRELA_HAEIN
    AccessioniPrimary (citable) accession number: P44644
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3