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P44644 (RELA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP pyrophosphokinase

EC=2.7.6.5
Alternative name(s):
(p)ppGpp synthase
ATP:GTP 3'-pyrophosphotransferase
ppGpp synthase I
Gene names
Name:relA
Ordered Locus Names:HI_0334
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length743 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp By similarity.

Catalytic activity

ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.

Sequence similarities

Belongs to the RelA/SpoT family.

Contains 1 ACT domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 743743GTP pyrophosphokinase
PRO_0000166549

Regions

Domain670 – 74374ACT

Sequences

Sequence LengthMass (Da)Tools
P44644 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 39B47619896AC211

FASTA74384,567
        10         20         30         40         50         60 
MVAVRGSHLL NPQDFVIEQW CTGLKLAEQT EKSLIDAWYY ARDLMNAYPD EMKNATLMLQ 

        70         80         90        100        110        120 
SGVEMVEILH ELNMDAETLL TAMLFPIVAN KLTDWESLKE KFGAKITKLL KGVLEMDNIR 

       130        140        150        160        170        180 
QLNASHSANA LQVDNVRRML LAMVDDFRCV IIKLAERITF LRDAEHRCAE EDKVLAVKEC 

       190        200        210        220        230        240 
SYIYAPLANR LGIGQLKWEL EDYCFRYLHP EQYRAIAKLL QERRLDREHY IADFVSELSG 

       250        260        270        280        290        300 
YLRENIEQVE VYGRPKHIYS IWRKMQKKHL EFSGLYDVRA VRIIVQKLQD CYTALGIVHT 

       310        320        330        340        350        360 
QFKHLPKEFD DYVANPKPNG YQSIHTVVLG KGGKPIEVQI RTQQMHDDAE LGMAAHWKYK 

       370        380        390        400        410        420 
EGNTGSMSAY EEKIAWLRKL LAWQDDITDS GEVLAELRSQ VFDDRVYVFT PKGEVVDLPT 

       430        440        450        460        470        480 
GSTPLDFAYA IHSEIGHRCI GAKVAGRIVP FTYQLQMGDQ IDIITQKNPN PSRDWLNPNL 

       490        500        510        520        530        540 
GFTHTAKSRA KIQAWFKKQD RDKNIPAGKE LLDNELALLN LSIKQVEPYA LPRYNLKNLD 

       550        560        570        580        590        600 
DLYAGIGSGD IRLNNLIHFL QSKLIKVTAE EADQEILRHV ANKSAVNSQQ KSEKNNGCVI 

       610        620        630        640        650        660 
VEGVDNLMHH IARCCQPIPG DAIVGYITMG RGISIHRADC EQFLDLQAAH PERVVESIWG 

       670        680        690        700        710        720 
ENYASGFHIN IRIVAGDRNG LLRDITTVLA NEKISVLGVS SRADTKKQLA TIDMEIELHN 

       730        740 
VESLSKILAR LAKLDDVIEA KRL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC21996.1.
PIRD64062.
RefSeqNP_438498.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44644.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0334.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC21996; AAC21996; HI_0334.
GeneID950822.
KEGGhin:HI0334.
PATRIC20189211. VBIHaeInf48452_0351.

Phylogenomic databases

eggNOGCOG0317.
KOK00951.
OMATEIGHNC.
OrthoDBEOG6SV551.
PhylomeDBP44644.

Enzyme and pathway databases

UniPathwayUPA00908; UER00884.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamPF01842. ACT. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
SMARTSM00954. RelA_SpoT. 1 hit.
[Graphical view]
SUPFAMSSF81271. SSF81271. 1 hit.
TIGRFAMsTIGR00691. spoT_relA. 1 hit.
PROSITEPS51671. ACT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRELA_HAEIN
AccessionPrimary (citable) accession number: P44644
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names