Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P44635

- NUDB_HAEIN

UniProt

P44635 - NUDB_HAEIN

Protein

Dihydroneopterin triphosphate pyrophosphatase

Gene

nudB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP By similarity.By similarity

    Cofactori

    Binds 1 magnesium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei14 – 141SubstrateBy similarity
    Binding sitei36 – 361SubstrateBy similarity
    Binding sitei47 – 471SubstrateBy similarity
    Metal bindingi63 – 631MagnesiumBy similarity
    Metal bindingi67 – 671MagnesiumBy similarity
    Metal bindingi124 – 1241MagnesiumBy similarity
    Binding sitei142 – 1421SubstrateSequence Analysis

    GO - Molecular functioni

    1. dATP pyrophosphohydrolase activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. DNA repair Source: InterPro
    2. folic acid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Folate biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydroneopterin triphosphate pyrophosphatase (EC:3.6.1.-)
    Alternative name(s):
    dATP pyrophosphohydrolase
    Gene namesi
    Name:nudB
    Synonyms:ntpA
    Ordered Locus Names:HI_0316
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 158158Dihydroneopterin triphosphate pyrophosphatasePRO_0000056955Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0316.

    Structurei

    3D structure databases

    ProteinModelPortaliP44635.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 153140Nudix hydrolasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni88 – 914Substrate bindingSequence Analysis

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi48 – 6922Nudix boxAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Nudix hydrolase family.Curated
    Contains 1 nudix hydrolase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0494.
    KOiK08310.
    OMAiTAIRELW.
    OrthoDBiEOG69WFKW.

    Family and domain databases

    Gene3Di3.90.79.10. 1 hit.
    InterProiIPR003564. dATP_pyrPHydro.
    IPR020084. NUDIX_hydrolase_CS.
    IPR000086. NUDIX_hydrolase_dom.
    IPR015797. NUDIX_hydrolase_dom-like.
    [Graphical view]
    PfamiPF00293. NUDIX. 1 hit.
    [Graphical view]
    PRINTSiPR01404. NPPPHYDRLASE.
    SUPFAMiSSF55811. SSF55811. 1 hit.
    PROSITEiPS51462. NUDIX. 1 hit.
    PS00893. NUDIX_BOX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P44635-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSDLTAFLM MQYKNNQSVL VVIYTKDTNR VLMLQRQDDP DFWQSVTGTI    50
    ESDETPKKTA IRELWEEVRL DISENSTALF DCNESIEFEI FPHFRYKYAP 100
    NITHCKEHWF LCEVEKEFIP VLSEHLDFCW VSAKKAVEMT KSQNNAEAIK 150
    KYLFNLRR 158
    Length:158
    Mass (Da):18,826
    Last modified:November 1, 1995 - v1
    Checksum:iA82B3750A5631553
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21980.1.
    PIRiH64147.
    RefSeqiNP_438482.2. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC21980; AAC21980; HI_0316.
    GeneIDi949449.
    KEGGihin:HI0316.
    PATRICi20189173. VBIHaeInf48452_0333.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21980.1 .
    PIRi H64147.
    RefSeqi NP_438482.2. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44635.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0316.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC21980 ; AAC21980 ; HI_0316 .
    GeneIDi 949449.
    KEGGi hin:HI0316.
    PATRICi 20189173. VBIHaeInf48452_0333.

    Phylogenomic databases

    eggNOGi COG0494.
    KOi K08310.
    OMAi TAIRELW.
    OrthoDBi EOG69WFKW.

    Family and domain databases

    Gene3Di 3.90.79.10. 1 hit.
    InterProi IPR003564. dATP_pyrPHydro.
    IPR020084. NUDIX_hydrolase_CS.
    IPR000086. NUDIX_hydrolase_dom.
    IPR015797. NUDIX_hydrolase_dom-like.
    [Graphical view ]
    Pfami PF00293. NUDIX. 1 hit.
    [Graphical view ]
    PRINTSi PR01404. NPPPHYDRLASE.
    SUPFAMi SSF55811. SSF55811. 1 hit.
    PROSITEi PS51462. NUDIX. 1 hit.
    PS00893. NUDIX_BOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiNUDB_HAEIN
    AccessioniPrimary (citable) accession number: P44635
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3