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P44635

- NUDB_HAEIN

UniProt

P44635 - NUDB_HAEIN

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Protein

Dihydroneopterin triphosphate pyrophosphatase

Gene
nudB, ntpA, HI_0316
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP By similarity.

Cofactori

Binds 1 magnesium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141Substrate By similarity
Binding sitei36 – 361Substrate By similarity
Binding sitei47 – 471Substrate By similarity
Metal bindingi63 – 631Magnesium By similarity
Metal bindingi67 – 671Magnesium By similarity
Metal bindingi124 – 1241Magnesium By similarity
Binding sitei142 – 1421Substrate Reviewed prediction

GO - Molecular functioni

  1. dATP pyrophosphohydrolase activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA repair Source: InterPro
  2. folic acid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Folate biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroneopterin triphosphate pyrophosphatase (EC:3.6.1.-)
Alternative name(s):
dATP pyrophosphohydrolase
Gene namesi
Name:nudB
Synonyms:ntpA
Ordered Locus Names:HI_0316
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 158158Dihydroneopterin triphosphate pyrophosphatasePRO_0000056955Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0316.

Structurei

3D structure databases

ProteinModelPortaliP44635.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 153140Nudix hydrolaseAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni88 – 914Substrate binding Reviewed prediction

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi48 – 6922Nudix boxAdd
BLAST

Sequence similaritiesi

Belongs to the Nudix hydrolase family.

Phylogenomic databases

eggNOGiCOG0494.
KOiK08310.
OMAiTAIRELW.
OrthoDBiEOG69WFKW.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR003564. dATP_pyrPHydro.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR01404. NPPPHYDRLASE.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44635-1 [UniParc]FASTAAdd to Basket

« Hide

MRSDLTAFLM MQYKNNQSVL VVIYTKDTNR VLMLQRQDDP DFWQSVTGTI    50
ESDETPKKTA IRELWEEVRL DISENSTALF DCNESIEFEI FPHFRYKYAP 100
NITHCKEHWF LCEVEKEFIP VLSEHLDFCW VSAKKAVEMT KSQNNAEAIK 150
KYLFNLRR 158
Length:158
Mass (Da):18,826
Last modified:November 1, 1995 - v1
Checksum:iA82B3750A5631553
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21980.1.
PIRiH64147.
RefSeqiNP_438482.2. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21980; AAC21980; HI_0316.
GeneIDi949449.
KEGGihin:HI0316.
PATRICi20189173. VBIHaeInf48452_0333.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21980.1 .
PIRi H64147.
RefSeqi NP_438482.2. NC_000907.1.

3D structure databases

ProteinModelPortali P44635.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0316.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21980 ; AAC21980 ; HI_0316 .
GeneIDi 949449.
KEGGi hin:HI0316.
PATRICi 20189173. VBIHaeInf48452_0333.

Phylogenomic databases

eggNOGi COG0494.
KOi K08310.
OMAi TAIRELW.
OrthoDBi EOG69WFKW.

Family and domain databases

Gene3Di 3.90.79.10. 1 hit.
InterProi IPR003564. dATP_pyrPHydro.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view ]
Pfami PF00293. NUDIX. 1 hit.
[Graphical view ]
PRINTSi PR01404. NPPPHYDRLASE.
SUPFAMi SSF55811. SSF55811. 1 hit.
PROSITEi PS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiNUDB_HAEIN
AccessioniPrimary (citable) accession number: P44635
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi