P44635 (NUDB_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dihydroneopterin triphosphate pyrophosphatase
EC=3.6.1.-

Alternative name(s):
dATP pyrophosphohydrolase

Gene names

Name:	nudB
Synonyms:	ntpA
Ordered Locus Names:	HI_0316

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP By similarity.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Sequence similarities	Belongs to the Nudix hydrolase family. Contains 1 nudix hydrolase domain.

Ontologies

Keywords
Biological process	Folate biosynthesis
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA repair Inferred from electronic annotation. Source: InterPro folic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	dATP pyrophosphohydrolase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 158	158	Dihydroneopterin triphosphate pyrophosphatase		PRO_0000056955
Regions
	Domain	14 – 153	140	Nudix hydrolase
	Region	88 – 91	4	Substrate binding Potential
	Motif	48 – 69	22	Nudix box
Sites
	Metal binding	63	1	Magnesium By similarity
	Metal binding	67	1	Magnesium By similarity
	Metal binding	124	1	Magnesium By similarity
	Binding site	14	1	Substrate By similarity
	Binding site	36	1	Substrate By similarity
	Binding site	47	1	Substrate By similarity
	Binding site	142	1	Substrate Potential

Sequences

	Sequence		Length	Mass (Da)
	P44635 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: A82B3750A5631553	FASTA	158	18,826
	10 20 30 40 50 60 MRSDLTAFLM MQYKNNQSVL VVIYTKDTNR VLMLQRQDDP DFWQSVTGTI ESDETPKKTA 70 80 90 100 110 120 IRELWEEVRL DISENSTALF DCNESIEFEI FPHFRYKYAP NITHCKEHWF LCEVEKEFIP 130 140 150 VLSEHLDFCW VSAKKAVEMT KSQNNAEAIK KYLFNLRR

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC21980.1.
PIR	H64147.
RefSeq	NP_438482.2. NC_000907.1.
3D structure databases
ProteinModelPortal	P44635.
ModBase	Search...
Protein-protein interaction databases
STRING	71421.HI0316.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC21980; AAC21980; HI_0316.
GeneID	949449.
KEGG	hin:HI0316.
PATRIC	20189173. VBIHaeInf48452_0333.
Phylogenomic databases
eggNOG	COG0494.
KO	K08310.
OMA	PGFWQSV.
ProtClustDB	PRK09438.
Family and domain databases
Gene3D	3.90.79.10. 1 hit.
InterPro	IPR003564. dATP_pyrPHydro. IPR020084. NUDIX_hydrolase_CS. IPR000086. NUDIX_hydrolase_dom. IPR015797. NUDIX_hydrolase_dom-like. [Graphical view]
Pfam	PF00293. NUDIX. 1 hit. [Graphical view]
PRINTS	PR01404. NPPPHYDRLASE.
SUPFAM	SSF55811. NUDIX_hydrolase. 1 hit.
PROSITE	PS51462. NUDIX. 1 hit. PS00893. NUDIX_BOX. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUDB_HAEIN

Accession

Primary (citable) accession number: P44635

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program