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P44635

- NUDB_HAEIN

UniProt

P44635 - NUDB_HAEIN

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Protein

Dihydroneopterin triphosphate pyrophosphatase

Gene

nudB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP (By similarity).By similarity

Cofactori

Binds 1 magnesium ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141SubstrateBy similarity
Binding sitei36 – 361SubstrateBy similarity
Binding sitei47 – 471SubstrateBy similarity
Metal bindingi63 – 631MagnesiumBy similarity
Metal bindingi67 – 671MagnesiumBy similarity
Metal bindingi124 – 1241MagnesiumBy similarity
Binding sitei142 – 1421SubstrateSequence Analysis

GO - Molecular functioni

  1. dATP pyrophosphohydrolase activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA repair Source: InterPro
  2. folic acid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Folate biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroneopterin triphosphate pyrophosphatase (EC:3.6.1.-)
Alternative name(s):
dATP pyrophosphohydrolase
Gene namesi
Name:nudB
Synonyms:ntpA
Ordered Locus Names:HI_0316
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 158158Dihydroneopterin triphosphate pyrophosphatasePRO_0000056955Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0316.

Structurei

3D structure databases

ProteinModelPortaliP44635.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 153140Nudix hydrolasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni88 – 914Substrate bindingSequence Analysis

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi48 – 6922Nudix boxAdd
BLAST

Sequence similaritiesi

Belongs to the Nudix hydrolase family.Curated
Contains 1 nudix hydrolase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0494.
KOiK08310.
OMAiTAIRELW.
OrthoDBiEOG69WFKW.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR003564. dATP_pyrPHydro.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR01404. NPPPHYDRLASE.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44635-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRSDLTAFLM MQYKNNQSVL VVIYTKDTNR VLMLQRQDDP DFWQSVTGTI
60 70 80 90 100
ESDETPKKTA IRELWEEVRL DISENSTALF DCNESIEFEI FPHFRYKYAP
110 120 130 140 150
NITHCKEHWF LCEVEKEFIP VLSEHLDFCW VSAKKAVEMT KSQNNAEAIK

KYLFNLRR
Length:158
Mass (Da):18,826
Last modified:November 1, 1995 - v1
Checksum:iA82B3750A5631553
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21980.1.
PIRiH64147.
RefSeqiNP_438482.2. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21980; AAC21980; HI_0316.
GeneIDi949449.
KEGGihin:HI0316.
PATRICi20189173. VBIHaeInf48452_0333.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21980.1 .
PIRi H64147.
RefSeqi NP_438482.2. NC_000907.1.

3D structure databases

ProteinModelPortali P44635.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0316.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21980 ; AAC21980 ; HI_0316 .
GeneIDi 949449.
KEGGi hin:HI0316.
PATRICi 20189173. VBIHaeInf48452_0333.

Phylogenomic databases

eggNOGi COG0494.
KOi K08310.
OMAi TAIRELW.
OrthoDBi EOG69WFKW.

Family and domain databases

Gene3Di 3.90.79.10. 1 hit.
InterProi IPR003564. dATP_pyrPHydro.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view ]
Pfami PF00293. NUDIX. 1 hit.
[Graphical view ]
PRINTSi PR01404. NPPPHYDRLASE.
SUPFAMi SSF55811. SSF55811. 1 hit.
PROSITEi PS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiNUDB_HAEIN
AccessioniPrimary (citable) accession number: P44635
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 1, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3