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P44635 (NUDB_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydroneopterin triphosphate pyrophosphatase

EC=3.6.1.-
Alternative name(s):
dATP pyrophosphohydrolase
Gene names
Name:nudB
Synonyms:ntpA
Ordered Locus Names:HI_0316
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length158 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP By similarity.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Sequence similarities

Belongs to the Nudix hydrolase family.

Contains 1 nudix hydrolase domain.

Ontologies

Keywords
   Biological processFolate biosynthesis
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA repair

Inferred from electronic annotation. Source: InterPro

folic acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiondATP pyrophosphohydrolase activity

Inferred from electronic annotation. Source: InterPro

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 158158Dihydroneopterin triphosphate pyrophosphatase
PRO_0000056955

Regions

Domain14 – 153140Nudix hydrolase
Region88 – 914Substrate binding Potential
Motif48 – 6922Nudix box

Sites

Metal binding631Magnesium By similarity
Metal binding671Magnesium By similarity
Metal binding1241Magnesium By similarity
Binding site141Substrate By similarity
Binding site361Substrate By similarity
Binding site471Substrate By similarity
Binding site1421Substrate Potential

Sequences

Sequence LengthMass (Da)Tools
P44635 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: A82B3750A5631553

FASTA15818,826
        10         20         30         40         50         60 
MRSDLTAFLM MQYKNNQSVL VVIYTKDTNR VLMLQRQDDP DFWQSVTGTI ESDETPKKTA 

        70         80         90        100        110        120 
IRELWEEVRL DISENSTALF DCNESIEFEI FPHFRYKYAP NITHCKEHWF LCEVEKEFIP 

       130        140        150 
VLSEHLDFCW VSAKKAVEMT KSQNNAEAIK KYLFNLRR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC21980.1.
PIRH64147.
RefSeqNP_438482.2. NC_000907.1.

3D structure databases

ProteinModelPortalP44635.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0316.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC21980; AAC21980; HI_0316.
GeneID949449.
KEGGhin:HI0316.
PATRIC20189173. VBIHaeInf48452_0333.

Phylogenomic databases

eggNOGCOG0494.
KOK08310.
OMAPGFWQSV.
OrthoDBEOG69WFKW.
ProtClustDBPRK09438.

Family and domain databases

Gene3D3.90.79.10. 1 hit.
InterProIPR003564. dATP_pyrPHydro.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSPR01404. NPPPHYDRLASE.
SUPFAMSSF55811. SSF55811. 1 hit.
PROSITEPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUDB_HAEIN
AccessionPrimary (citable) accession number: P44635
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 13, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names