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P44624

- AMPD_HAEIN

UniProt

P44624 - AMPD_HAEIN

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Protein
1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD
Gene
ampD, HI_0300
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in both cell wall peptidoglycans recycling and beta-lactamase induction. Specifically cleaves the amide bond between the lactyl group of N-acetylmuramic acid and the alpha-amino group of the L-alanine in degradation products containing an anhydro N-acetylmuramyl moiety By similarity.

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

Cofactori

Zinc; required for amidase activity By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi38 – 381Zinc; catalytic By similarity
Active sitei120 – 1201Proton acceptor By similarity
Metal bindingi159 – 1591Zinc; catalytic By similarity
Sitei167 – 1671Transition state stabilizer By similarity
Metal bindingi169 – 1691Zinc; catalytic By similarity

GO - Molecular functioni

  1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Cell wall biogenesis/degradation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD (EC:3.5.1.28)
Alternative name(s):
N-acetylmuramoyl-L-alanine amidase
Gene namesi
Name:ampD
Ordered Locus Names:HI_0300
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1841841,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD
PRO_0000164414Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0300.

Structurei

3D structure databases

ProteinModelPortaliP44624.
SMRiP44624. Positions 6-183.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3023.
KOiK03806.
OMAiCEDRAWH.
OrthoDBiEOG60GRR5.
PhylomeDBiP44624.

Family and domain databases

Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
[Graphical view]
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
SMARTiSM00644. Ami_2. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.

Sequencei

Sequence statusi: Complete.

P44624-1 [UniParc]FASTAAdd to Basket

« Hide

MRKIKDIEKG LLTDCRQIQS PHFDKRPNPQ DISLLVIHYI SLPPEQFGGG    50
YVDDFFQGKL DPKIHPYFAE IYQMRVSAHC LIERNGRITQ YVNFNDRAWH 100
AGVSNFQGRE KCNDFAIGIE LEGSNEQPFT DAQYFSLQEL TNVIMKSYPK 150
ITKDRIVGHC DISPKRKIDP GQYFDWERYL SSVK 184
Length:184
Mass (Da):21,448
Last modified:November 1, 1995 - v1
Checksum:iB7A035527E328401
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21965.1.
PIRiF64060.
RefSeqiNP_438467.1. NC_000907.1.
WP_005694366.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21965; AAC21965; HI_0300.
GeneIDi949420.
KEGGihin:HI0300.
PATRICi20189141. VBIHaeInf48452_0317.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21965.1 .
PIRi F64060.
RefSeqi NP_438467.1. NC_000907.1.
WP_005694366.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44624.
SMRi P44624. Positions 6-183.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0300.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21965 ; AAC21965 ; HI_0300 .
GeneIDi 949420.
KEGGi hin:HI0300.
PATRICi 20189141. VBIHaeInf48452_0317.

Phylogenomic databases

eggNOGi COG3023.
KOi K03806.
OMAi CEDRAWH.
OrthoDBi EOG60GRR5.
PhylomeDBi P44624.

Family and domain databases

Gene3Di 3.40.80.10. 1 hit.
InterProi IPR002502. Amidase_domain.
[Graphical view ]
Pfami PF01510. Amidase_2. 1 hit.
[Graphical view ]
SMARTi SM00644. Ami_2. 1 hit.
[Graphical view ]
SUPFAMi SSF55846. SSF55846. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiAMPD_HAEIN
AccessioniPrimary (citable) accession number: P44624
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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