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P44624

- AMPD_HAEIN

UniProt

P44624 - AMPD_HAEIN

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Protein

1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD

Gene

ampD

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in both cell wall peptidoglycans recycling and beta-lactamase induction. Specifically cleaves the amide bond between the lactyl group of N-acetylmuramic acid and the alpha-amino group of the L-alanine in degradation products containing an anhydro N-acetylmuramyl moiety (By similarity).By similarity

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

Cofactori

Zinc; required for amidase activity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi38 – 381Zinc; catalyticBy similarity
Active sitei120 – 1201Proton acceptorBy similarity
Metal bindingi159 – 1591Zinc; catalyticBy similarity
Sitei167 – 1671Transition state stabilizerBy similarity
Metal bindingi169 – 1691Zinc; catalyticBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Cell wall biogenesis/degradation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD (EC:3.5.1.28)
Alternative name(s):
N-acetylmuramoyl-L-alanine amidase
Gene namesi
Name:ampD
Ordered Locus Names:HI_0300
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1841841,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpDPRO_0000164414Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0300.

Structurei

3D structure databases

ProteinModelPortaliP44624.
SMRiP44624. Positions 6-183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3023.
KOiK03806.
OMAiCEDRAWH.
OrthoDBiEOG60GRR5.
PhylomeDBiP44624.

Family and domain databases

Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
[Graphical view]
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
SMARTiSM00644. Ami_2. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.

Sequencei

Sequence statusi: Complete.

P44624-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRKIKDIEKG LLTDCRQIQS PHFDKRPNPQ DISLLVIHYI SLPPEQFGGG
60 70 80 90 100
YVDDFFQGKL DPKIHPYFAE IYQMRVSAHC LIERNGRITQ YVNFNDRAWH
110 120 130 140 150
AGVSNFQGRE KCNDFAIGIE LEGSNEQPFT DAQYFSLQEL TNVIMKSYPK
160 170 180
ITKDRIVGHC DISPKRKIDP GQYFDWERYL SSVK
Length:184
Mass (Da):21,448
Last modified:November 1, 1995 - v1
Checksum:iB7A035527E328401
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21965.1.
PIRiF64060.
RefSeqiNP_438467.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21965; AAC21965; HI_0300.
GeneIDi949420.
KEGGihin:HI0300.
PATRICi20189141. VBIHaeInf48452_0317.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21965.1 .
PIRi F64060.
RefSeqi NP_438467.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44624.
SMRi P44624. Positions 6-183.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0300.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21965 ; AAC21965 ; HI_0300 .
GeneIDi 949420.
KEGGi hin:HI0300.
PATRICi 20189141. VBIHaeInf48452_0317.

Phylogenomic databases

eggNOGi COG3023.
KOi K03806.
OMAi CEDRAWH.
OrthoDBi EOG60GRR5.
PhylomeDBi P44624.

Family and domain databases

Gene3Di 3.40.80.10. 1 hit.
InterProi IPR002502. Amidase_domain.
[Graphical view ]
Pfami PF01510. Amidase_2. 1 hit.
[Graphical view ]
SMARTi SM00644. Ami_2. 1 hit.
[Graphical view ]
SUPFAMi SSF55846. SSF55846. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiAMPD_HAEIN
AccessioniPrimary (citable) accession number: P44624
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3