ID   HOFC_HAEIN              Reviewed;         406 AA.
AC   P44621;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   27-MAR-2024, entry version 121.
DE   RecName: Full=Protein transport protein HofC homolog;
GN   Name=hofC; Synonyms=hopC; OrderedLocusNames=HI_0297;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GSP F family. {ECO:0000305}.
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DR   EMBL; L42023; AAC21961.1; -; Genomic_DNA.
DR   PIR; D64060; D64060.
DR   RefSeq; NP_438464.1; NC_000907.1.
DR   AlphaFoldDB; P44621; -.
DR   SMR; P44621; -.
DR   STRING; 71421.HI_0297; -.
DR   EnsemblBacteria; AAC21961; AAC21961; HI_0297.
DR   KEGG; hin:HI_0297; -.
DR   PATRIC; fig|71421.8.peg.313; -.
DR   eggNOG; COG1459; Bacteria.
DR   HOGENOM; CLU_035032_0_1_6; -.
DR   OrthoDB; 9805682at2; -.
DR   PhylomeDB; P44621; -.
DR   BioCyc; HINF71421:G1GJ1-315-MONOMER; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015628; P:protein secretion by the type II secretion system; IBA:GO_Central.
DR   Gene3D; 1.20.81.30; Type II secretion system (T2SS), domain F; 2.
DR   InterPro; IPR003004; GspF/PilC.
DR   InterPro; IPR001992; T2SS_GspF/T4SS_PilC_CS.
DR   InterPro; IPR018076; T2SS_GspF_dom.
DR   InterPro; IPR042094; T2SS_GspF_sf.
DR   PANTHER; PTHR30012; GENERAL SECRETION PATHWAY PROTEIN; 1.
DR   PANTHER; PTHR30012:SF7; PROTEIN TRANSPORT PROTEIN HOFC HOMOLOG; 1.
DR   Pfam; PF00482; T2SSF; 2.
DR   PRINTS; PR00812; BCTERIALGSPF.
DR   PROSITE; PS00874; T2SP_F; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..406
FT                   /note="Protein transport protein HofC homolog"
FT                   /id="PRO_0000207846"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        379..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   406 AA;  46291 MW;  429D83B7C10F8F82 CRC64;
     MTKKLFYYQA SNPLNQKQKG SIIADTKQQA HFQLISRGLT HIKLQQNWQF GAKPKNSEIS
     ELLNQLATLL QSAIPLKNSL QILQQNCTQI VLNEWLERLL QSIESGLAFS QAIEQQGKYL
     TQQEIQLIQV GEMTGKLAVV CKKIATHRSQ SLALQRKLQK IMLYPSMVLG ISLLLTLALL
     LFIVPQFAEM YSGNNAELPT ITAILLSISN FLKQNIGILL FFVLSFFLFY YFYLKRQTWF
     YQKKNQLISI TPIFGTIQKL SRLVNFSQSL QIMLQAGVPL NQALDSFLPR TQTWQTKKTL
     VNDIVLDKEV RSILQWVSQG YAFSNSVSSD LFPMEAQQML QIGEQSGKLA LMLEHIAENY
     QEKLNHQIDL LSQMLEPLMM VIIGSLIGII MMGMYLPIFN MGSVIQ
//