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P44612 (MEND_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
Short name=SEPHCHC synthase
EC=2.2.1.9
Alternative name(s):
Menaquinone biosynthesis protein MenD
Gene names
Name:menD
Ordered Locus Names:HI_0283
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length568 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) By similarity. HAMAP MF_01659

Catalytic activity

Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2. HAMAP MF_01659

Cofactor

Magnesium or manganese By similarity. HAMAP MF_01659

Binds 1 thiamine pyrophosphate per subunit By similarity.

Pathway

Cofactor biosynthesis; menaquinone biosynthesis; menaquinone-2 from chorismate: step 2/8. HAMAP MF_01659

Subunit structure

Homodimer By similarity. HAMAP MF_01659

Sequence similarities

Belongs to the TPP enzyme family. MenD subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 5685682-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase HAMAP MF_01659
PRO_0000090830

Sequences

Sequence LengthMass (Da)Tools
P44612 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: C0BE9A36E7EAAE4F

FASTA56863,097
        10         20         30         40         50         60 
MSVSVFNRCW SKVILETLVR QGVSHLCIAP GSRSTPLTLE AVRLQNAGAV TCHTHFDERG 

        70         80         90        100        110        120 
LGFFALGIAK ATQSPVAIIV TSGTATANLY PAIIEARQTG VNLFVLTADR PPELWECGAN 

       130        140        150        160        170        180 
QAILQQNMFG QYPVANVNLP KPNADYSAQW LISLLEQAVF QQKQQGGVVH INVPFAEPLY 

       190        200        210        220        230        240 
DATDEEVNSH SWLQPLQRWL IQNKSWINVE AQQNEVLMHE NWDHWRTKRG VVVVGQLPAE 

       250        260        270        280        290        300 
QAMGINSWAS AMGWVLLTDI QSGVVPTTPY EDIWLANQTV REKLLQADIV IQFGARFISK 

       310        320        330        340        350        360 
RINQFLQAFK GEFWLVEQSG KALDPYHHSL TRFNAKVHHW LRAHPPLRQK PWLLEPLALS 

       370        380        390        400        410        420 
KFCATFIEQQ VGGNLTEASL ALRLPTLLPY NGVLFLGNSL LVRLVDALTQ LPESYPVYTN 

       430        440        450        460        470        480 
RGASGIDGLL ATAAGIGIGS NKPVVAVIGD TSTLYDLNSF ALFKNVTQPT LIFVINNNGG 

       490        500        510        520        530        540 
AIFDMLPVDE QVKDQFYRLP HNGDFSQIAA MFDLKYAHPY TWADLNSVVK QAYSRRKATL 

       550        560 
IEIKTNPSDG SSLYKRLIEQ ISHAVIGA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L42023 Genomic DNA. Translation: AAC21946.1.
PIRD64059.
RefSeqNP_438451.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44612.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID949474.
GenomeReviewsGene locus HI_0283 in contig L42023_GR.
KEGGhin:HI0283.
NMPDRfig|71421.1.peg.266.
PATRIC20189105. VBIHaeInf48452_0299.
TIGRHI_0283.

Phylogenomic databases

HOGENOMHBG634405.
OMAICTSGTA.
PhylomeDBP44612.
ProtClustDBPRK07449.

Enzyme and pathway databases

BioCycHINF71421:HI_0283-MONOMER.

Family and domain databases

HAMAPMF_01659. MenD.
[Tree]
InterProIPR004433. MenaQ_synth_MenD.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR011766. TPP_enzyme-bd_C.
[Graphical view]
KOK02551.
PANTHERPTHR18968:SF3. PTHR18968:SF3. 1 hit.
PfamPF02775. TPP_enzyme_C. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
PIRSFPIRSF004983. MenD. 1 hit.
TIGRFAMsTIGR00173. MenD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMEND_HAEIN
AccessionPrimary (citable) accession number: P44612
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 25, 2012
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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