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Protein

Sensor protein NarQ homolog

Gene

narQ

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable member of a two-component regulatory system. It is not known what protein it phosphorylates and in which regulatory pathway it acts, as the narL and other nar genes do not exist in H.influenzae.

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.13.3. 2529.

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor protein NarQ homolog (EC:2.7.13.3)
Gene namesi
Name:narQ
Ordered Locus Names:HI_0267
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313CytoplasmicSequence analysisAdd
BLAST
Transmembranei14 – 3421HelicalSequence analysisAdd
BLAST
Topological domaini35 – 147113PeriplasmicSequence analysisAdd
BLAST
Transmembranei148 – 17225HelicalSequence analysisAdd
BLAST
Topological domaini173 – 567395CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 567567Sensor protein NarQ homologPRO_0000074811Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei373 – 3731Phosphohistidine; by autocatalysisPROSITE-ProRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0267.

Structurei

3D structure databases

ProteinModelPortaliP44604.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini175 – 22854HAMPPROSITE-ProRule annotationAdd
BLAST
Domaini367 – 566200Histidine kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HAMP domain.PROSITE-ProRule annotation
Contains 1 histidine kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
KOiK07674.
OMAiFLQIQLT.
OrthoDBiEOG6JX7HQ.
PhylomeDBiP44604.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR029095. NarX-like_N.
IPR016380. Sig_transdc_His_kin_NarX/NarQ.
IPR011712. Sig_transdc_His_kin_sub3_dim/P.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF07730. HisKA_3. 1 hit.
PF13675. PilJ. 1 hit.
[Graphical view]
PIRSFiPIRSF003167. STHK_NarX/NarQ. 1 hit.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44604-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYTKGSVSTR IAKYLFIILI VAGVISSLSL AIMSSNKYDA EAINISGSLR
60 70 80 90 100
MQSYRLLYEM QEQPESVETN LRRYHISLHS SALLEVQNQF FTPNVLKHSY
110 120 130 140 150
QNILQRWTNM EKYARQQDVK NYSKQLTDYV ADVDYFVFEL QRFSEQKWIL
160 170 180 190 200
GVSVLGFAML LILLMVSYVI WYTNREVVKP LHLMTKASMQ VQMRQFNHIP
210 220 230 240 250
LDTRKQNELG TLARVFTQMS TELGQLYSRL EEAVNEKTQK LRQTNRTLST
260 270 280 290 300
LYQSAQLLNT NTINDKILNQ VLNYIFISDH LNFVKVEVMG AEHWDITLGK
310 320 330 340 350
QDANNELQIE TLSVDNEELG VLSWQAGLPC PDPRIMQNLA QMLARALYFH
360 370 380 390 400
KNLRQKEQLL LMEERSIIAR ELHDSLAQVL SFLQIQLTLL KHNLKKEDEQ
410 420 430 440 450
SKEKSLAIIA NFEQALSGGY AQLRELLATF RLTIQEANLQ LALKQVIDSL
460 470 480 490 500
RSQTTMQMNV NCQLPSQSLN PQQLVHVLQI VREATTNAIK HSQGTVIEIS
510 520 530 540 550
ARINAEGEYE ILVEDDGVGI PNLEEPEGHY GLNIMAERCR QLNAQLHIHR
560
REQGGTQVKI TLPHTLY
Length:567
Mass (Da):65,238
Last modified:November 1, 1995 - v1
Checksum:iA74F54998C6ECAB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21933.1.
PIRiF64058.
RefSeqiNP_438436.1. NC_000907.1.
WP_005694037.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21933; AAC21933; HI_0267.
GeneIDi949389.
KEGGihin:HI0267.
PATRICi20189061. VBIHaeInf48452_0282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21933.1.
PIRiF64058.
RefSeqiNP_438436.1. NC_000907.1.
WP_005694037.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP44604.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0267.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC21933; AAC21933; HI_0267.
GeneIDi949389.
KEGGihin:HI0267.
PATRICi20189061. VBIHaeInf48452_0282.

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
KOiK07674.
OMAiFLQIQLT.
OrthoDBiEOG6JX7HQ.
PhylomeDBiP44604.

Enzyme and pathway databases

BRENDAi2.7.13.3. 2529.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR029095. NarX-like_N.
IPR016380. Sig_transdc_His_kin_NarX/NarQ.
IPR011712. Sig_transdc_His_kin_sub3_dim/P.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF07730. HisKA_3. 1 hit.
PF13675. PilJ. 1 hit.
[Graphical view]
PIRSFiPIRSF003167. STHK_NarX/NarQ. 1 hit.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiNARQ_HAEIN
AccessioniPrimary (citable) accession number: P44604
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 11, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.