P44589 (ARSC_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative arsenate reductase
EC=1.20.4.1

Gene names

Name:	arsC
Synonyms:	arsG
Ordered Locus Names:	HI_0236

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	116 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Reduction of arsenate [As(V)] to arsenite [As(III)] Potential.
Catalytic activity	Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H2O.
Sequence similarities	Belongs to the ArsC family.

Ontologies

Keywords
Biological process	Arsenical resistance
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	response to arsenic-containing substance Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arsenate reductase (glutaredoxin) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 116	116	Putative arsenate reductase		PRO_0000162539

Sequences

	Sequence		Length	Mass (Da)
	P44589 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 4780A59D04C4247E	FASTA	116	13,228
	10 20 30 40 50 60 MSVIIYHNPH CSKSRETLAL LENKGIQPII ELYLQKQYSV NELQSIAKKL GIDDVRQMMR 70 80 90 100 110 TKDELYKSLN LDNLDLSQAE LFKAISEHSA LIERPIVING DKAKIGRPPE TVLEIL

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC21906.1.
PIR	G64056.
RefSeq	NP_438407.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P44589.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	951153.
GenomeReviews	Gene locus HI_0236 in contig L42023_GR.
KEGG	hin:HI0236.
PATRIC	20188997. VBIHaeInf48452_0251.
TIGR	HI_0236.
Phylogenomic databases
HOGENOM	HBG734370.
OMA	QIDYIEK.
ProtClustDB	CLSK789665.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0236-MONOMER.
Family and domain databases
InterPro	IPR006659. Arsenate_reductase. IPR006660. Arsenate_reductase-like. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K00537.
Pfam	PF03960. ArsC. 1 hit. [Graphical view]
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMs	TIGR00014. ArsC. 1 hit.
PROSITE	PS51353. ARSC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARSC_HAEIN

Accession

Primary (citable) accession number: P44589

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program