Reviewed, UniProtKB/Swiss-Prot P44578 (ARCB_HAEIN)

Names and origin

Protein names

Recommended name:
    Aerobic respiration control sensor protein arcB homolog
    EC=2.7.13.3

Gene names

Name:	arcB
Ordered Locus Names:	HI0220

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Member of the two-component regulatory system arcB/arcA. Activates arcA by phosphorylation By similarity.
Catalytic activity	ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
Subcellular location	Cell inner membrane; Multi-pass membrane protein Probable.
Sequence similarities	Contains 1 histidine kinase domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Two-component regulatory system
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	peptidyl-histidine phosphorylation Inferred from electronic annotation. Source: InterPro regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW two-component signal transduction system (phosphorelay) Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW two-component sensor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 325	325	Aerobic respiration control sensor protein arcB homolog		PRO_0000074686
Regions
	Topological domain	1 – 26	26	Cytoplasmic Potential
	Transmembrane	27 – 47	21	Potential
	Topological domain	48 – 57	10	Periplasmic Potential
	Transmembrane	58 – 78	21	Potential
	Topological domain	79 – 325	247	Cytoplasmic Potential
	Domain	128 – 325	198	Histidine kinase
Amino acid modifications
	Modified residue	131	1	Phosphohistidine; by autocatalysis By similarity

Sequences

	Sequence		Length	Mass (Da)
	P44578-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 5D1E952870CCA21B	FASTA	325	37,249
	10 20 30 40 50 60 MKNFKYFAQS YVDWVIRLGR LRFSLLGVMI LAVLALCTQI LFSLFIVHQI SWVDIFRSVT 70 80 90 100 110 120 FGLLTAPFVI YFFTLLVEKL EHSRLDLSSS VNRLENEVAE RIAAQKKLSQ ALEKLEKNSR 130 140 150 160 170 180 DKSTLLATIS HEFRTPLNGI VGLSQILLDD ELDDLQRNYL KTINISAVSL GYIFSDIIDL 190 200 210 220 230 240 EKIDASRIEL NRQPTDFPAL LNDIYNFASF LAKEKNLIFS LELEPNLPNW LNLDRVRLSQ 250 260 270 280 290 300 ILWNLISNAV KFTDQGNIIL KIMRNQDCYH FIVKDTGMGI SPEEQKHIFE MYYQVKESRQ 310 320 QSAGSGIGLA ISKNLAQLMG RGFNS

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L42023 Genomic DNA. No translation available.
PIR	G64055.
3D structure databases
ModBase	Search...
Genome annotation databases
GenomeReviews	Gene locus HI0220 in contig L42023_GR.
KEGG	hin:HI0220.
TIGR	HI0220.
Enzyme and pathway databases
BRENDA	2.7.13.3. 109.
Family and domain databases
InterPro	IPR003594. ATP_bd_ATPase. IPR004358. Sig_transdc_His_kin-like_C. IPR003661. Sig_transdc_His_kin_sub1_dim/P. IPR005467. Sig_transdc_His_kinase_core. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit.
Pfam	PF02518. HATPase_c. 1 hit. PF00512. HisKA. 1 hit. [Graphical view]
PRINTS	PR00344. BCTRLSENSOR.
SMART	SM00387. HATPase_c. 1 hit. SM00388. HisKA. 1 hit. [Graphical view]
PROSITE	PS50109. HIS_KIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARCB_HAEIN

Accession

Primary (citable) accession number: P44578

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	October 13, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)