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Protein

Oligopeptidase A

Gene

prlC

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala4 (By similarity).By similarity

Catalytic activityi

Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)5.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi470Zinc; catalyticPROSITE-ProRule annotation1
Active sitei471PROSITE-ProRule annotation1
Metal bindingi474Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi477Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM03.004

Names & Taxonomyi

Protein namesi
Recommended name:
Oligopeptidase A (EC:3.4.24.70)
Gene namesi
Name:prlC
Ordered Locus Names:HI_0214
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000781611 – 681Oligopeptidase AAdd BLAST681

Proteomic databases

PRIDEiP44573

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0214

Structurei

3D structure databases

ProteinModelPortaliP44573
SMRiP44573
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Phylogenomic databases

eggNOGiENOG4105DGW Bacteria
COG0339 LUCA
KOiK01414
OMAiINGVAWD

Family and domain databases

CDDicd06456 M3A_DCP, 1 hit
Gene3Di1.10.1370.10, 2 hits
InterProiView protein in InterPro
IPR034005 M3A_DCP
IPR024077 Neurolysin/TOP_dom2
IPR001567 Pept_M3A_M3B
PfamiView protein in Pfam
PF01432 Peptidase_M3, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

P44573-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMSNPLLNI QGLPPFSQIK PEHIRPAVEK LIQDCRNTIE QVLKQPHFTW
60 70 80 90 100
ENFILPLTET NDRLNRAWSP VSHLNSVKNS TELREAYQTC LPLLSEYSTW
110 120 130 140 150
VGQHKGLYNA YLALKNSAEF ADYSIAQKKA IENSLRDFEL SGIGLSEEKQ
160 170 180 190 200
QRYGEIVARL SELNSQFSNN VLDATMGWEK LIENEAELAG LPESALQAAQ
210 220 230 240 250
QSAESKGLKG YRFTLEIPSY LPVMTYCENR ALREEMYRAY ATRASEQGPN
260 270 280 290 300
AGKWDNSKVM EEILTLRVEL AKLLGFNTYT ELSLATKMAE NPQQVLDFLD
310 320 330 340 350
HLAERAKPQG EKELQELKGY CEKEFGVTEL APWDIGFYSE KQKQHLYAIN
360 370 380 390 400
DEELRPYFPE NRVISGLFEL IKRIFNIRAV ERKGVDTWHK DVRFFDLIDE
410 420 430 440 450
NDQLRGSFYL DLYAREHKRG GAWMDDCIGR KRKLDGSIET PVAYLTCNFN
460 470 480 490 500
APIGNKPALF THNEVTTLFH EFGHGIHHML TQIDVSDVAG INGVPWDAVE
510 520 530 540 550
LPSQFMENWC WEEEALAFIS GHYETGEPLP KEKLTQLLKA KNFQAAMFIL
560 570 580 590 600
RQLEFGIFDF RLHHTFDAEK TNQILDTLKS VKSQVAVIKG VDWARAPHSF
610 620 630 640 650
SHIFAGGYAA GYYSYLWAEV LSADAYSRFE EEGIFNPITG KSFLDEILTR
660 670 680
GGSEEPMELF KRFRGREPQL DALLRHKGIM N
Length:681
Mass (Da):78,017
Last modified:November 1, 1995 - v1
Checksum:i1452905A001ECFC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC21882.1
PIRiC64055
RefSeqiNP_438383.2, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC21882; AAC21882; HI_0214
GeneIDi951121
KEGGihin:HI0214
PATRICifig|71421.8.peg.219

Entry informationi

Entry nameiOPDA_HAEIN
AccessioniPrimary (citable) accession number: P44573
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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