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P44573

- OPDA_HAEIN

UniProt

P44573 - OPDA_HAEIN

Protein

Oligopeptidase A

Gene

prlC

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala4 By similarity.By similarity

    Catalytic activityi

    Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)5.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi470 – 4701Zinc; catalyticPROSITE-ProRule annotation
    Active sitei471 – 4711PROSITE-ProRule annotation
    Metal bindingi474 – 4741Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi477 – 4771Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oligopeptidase A (EC:3.4.24.70)
    Gene namesi
    Name:prlC
    Ordered Locus Names:HI_0214
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 681681Oligopeptidase APRO_0000078161Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0214.

    Structurei

    3D structure databases

    ProteinModelPortaliP44573.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Phylogenomic databases

    eggNOGiCOG0339.
    KOiK01414.
    OMAiTYCENRA.
    OrthoDBiEOG6WHNPN.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 1 hit.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P44573-1 [UniParc]FASTAAdd to Basket

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    MSMSNPLLNI QGLPPFSQIK PEHIRPAVEK LIQDCRNTIE QVLKQPHFTW    50
    ENFILPLTET NDRLNRAWSP VSHLNSVKNS TELREAYQTC LPLLSEYSTW 100
    VGQHKGLYNA YLALKNSAEF ADYSIAQKKA IENSLRDFEL SGIGLSEEKQ 150
    QRYGEIVARL SELNSQFSNN VLDATMGWEK LIENEAELAG LPESALQAAQ 200
    QSAESKGLKG YRFTLEIPSY LPVMTYCENR ALREEMYRAY ATRASEQGPN 250
    AGKWDNSKVM EEILTLRVEL AKLLGFNTYT ELSLATKMAE NPQQVLDFLD 300
    HLAERAKPQG EKELQELKGY CEKEFGVTEL APWDIGFYSE KQKQHLYAIN 350
    DEELRPYFPE NRVISGLFEL IKRIFNIRAV ERKGVDTWHK DVRFFDLIDE 400
    NDQLRGSFYL DLYAREHKRG GAWMDDCIGR KRKLDGSIET PVAYLTCNFN 450
    APIGNKPALF THNEVTTLFH EFGHGIHHML TQIDVSDVAG INGVPWDAVE 500
    LPSQFMENWC WEEEALAFIS GHYETGEPLP KEKLTQLLKA KNFQAAMFIL 550
    RQLEFGIFDF RLHHTFDAEK TNQILDTLKS VKSQVAVIKG VDWARAPHSF 600
    SHIFAGGYAA GYYSYLWAEV LSADAYSRFE EEGIFNPITG KSFLDEILTR 650
    GGSEEPMELF KRFRGREPQL DALLRHKGIM N 681
    Length:681
    Mass (Da):78,017
    Last modified:November 1, 1995 - v1
    Checksum:i1452905A001ECFC5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21882.1.
    PIRiC64055.
    RefSeqiNP_438383.2. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC21882; AAC21882; HI_0214.
    GeneIDi951121.
    KEGGihin:HI0214.
    PATRICi20188925. VBIHaeInf48452_0219.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21882.1 .
    PIRi C64055.
    RefSeqi NP_438383.2. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44573.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0214.

    Protein family/group databases

    MEROPSi M03.004.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC21882 ; AAC21882 ; HI_0214 .
    GeneIDi 951121.
    KEGGi hin:HI0214.
    PATRICi 20188925. VBIHaeInf48452_0219.

    Phylogenomic databases

    eggNOGi COG0339.
    KOi K01414.
    OMAi TYCENRA.
    OrthoDBi EOG6WHNPN.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 1 hit.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiOPDA_HAEIN
    AccessioniPrimary (citable) accession number: P44573
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3