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P44573

- OPDA_HAEIN

UniProt

P44573 - OPDA_HAEIN

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Protein

Oligopeptidase A

Gene

prlC

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala4 (By similarity).By similarity

Catalytic activityi

Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)5.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi470 – 4701Zinc; catalyticPROSITE-ProRule annotation
Active sitei471 – 4711PROSITE-ProRule annotation
Metal bindingi474 – 4741Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi477 – 4771Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Oligopeptidase A (EC:3.4.24.70)
Gene namesi
Name:prlC
Ordered Locus Names:HI_0214
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 681681Oligopeptidase APRO_0000078161Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0214.

Structurei

3D structure databases

ProteinModelPortaliP44573.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Phylogenomic databases

eggNOGiCOG0339.
KOiK01414.
OMAiTYCENRA.
OrthoDBiEOG6WHNPN.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44573-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSMSNPLLNI QGLPPFSQIK PEHIRPAVEK LIQDCRNTIE QVLKQPHFTW
60 70 80 90 100
ENFILPLTET NDRLNRAWSP VSHLNSVKNS TELREAYQTC LPLLSEYSTW
110 120 130 140 150
VGQHKGLYNA YLALKNSAEF ADYSIAQKKA IENSLRDFEL SGIGLSEEKQ
160 170 180 190 200
QRYGEIVARL SELNSQFSNN VLDATMGWEK LIENEAELAG LPESALQAAQ
210 220 230 240 250
QSAESKGLKG YRFTLEIPSY LPVMTYCENR ALREEMYRAY ATRASEQGPN
260 270 280 290 300
AGKWDNSKVM EEILTLRVEL AKLLGFNTYT ELSLATKMAE NPQQVLDFLD
310 320 330 340 350
HLAERAKPQG EKELQELKGY CEKEFGVTEL APWDIGFYSE KQKQHLYAIN
360 370 380 390 400
DEELRPYFPE NRVISGLFEL IKRIFNIRAV ERKGVDTWHK DVRFFDLIDE
410 420 430 440 450
NDQLRGSFYL DLYAREHKRG GAWMDDCIGR KRKLDGSIET PVAYLTCNFN
460 470 480 490 500
APIGNKPALF THNEVTTLFH EFGHGIHHML TQIDVSDVAG INGVPWDAVE
510 520 530 540 550
LPSQFMENWC WEEEALAFIS GHYETGEPLP KEKLTQLLKA KNFQAAMFIL
560 570 580 590 600
RQLEFGIFDF RLHHTFDAEK TNQILDTLKS VKSQVAVIKG VDWARAPHSF
610 620 630 640 650
SHIFAGGYAA GYYSYLWAEV LSADAYSRFE EEGIFNPITG KSFLDEILTR
660 670 680
GGSEEPMELF KRFRGREPQL DALLRHKGIM N
Length:681
Mass (Da):78,017
Last modified:November 1, 1995 - v1
Checksum:i1452905A001ECFC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21882.1.
PIRiC64055.
RefSeqiNP_438383.2. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21882; AAC21882; HI_0214.
GeneIDi951121.
KEGGihin:HI0214.
PATRICi20188925. VBIHaeInf48452_0219.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21882.1 .
PIRi C64055.
RefSeqi NP_438383.2. NC_000907.1.

3D structure databases

ProteinModelPortali P44573.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0214.

Protein family/group databases

MEROPSi M03.004.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21882 ; AAC21882 ; HI_0214 .
GeneIDi 951121.
KEGGi hin:HI0214.
PATRICi 20188925. VBIHaeInf48452_0219.

Phylogenomic databases

eggNOGi COG0339.
KOi K01414.
OMAi TYCENRA.
OrthoDBi EOG6WHNPN.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiOPDA_HAEIN
AccessioniPrimary (citable) accession number: P44573
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3