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P44573 (OPDA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Oligopeptidase A
EC=3.4.24.70
Gene names
Name:prlC
Ordered Locus Names:HI_0214
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus ›

Protein attributes

Sequence length681 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala4 By similarity.

Catalytic activity

Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)5.

Cofactor

Binds 1 zinc ion By similarity.

Sequence similarities

Belongs to the peptidase M3 family.

Ontologies

Keywords
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
Metalloprotease
Protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

metalloendopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 681681Oligopeptidase A
PRO_0000078161

Sites

Active site4711 By similarity
Metal binding4701Zinc; catalytic By similarity
Metal binding4741Zinc; catalytic By similarity
Metal binding4771Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
P44573 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 1452905A001ECFC5

FASTA68178,017
        10         20         30         40         50         60 
MSMSNPLLNI QGLPPFSQIK PEHIRPAVEK LIQDCRNTIE QVLKQPHFTW ENFILPLTET 

        70         80         90        100        110        120 
NDRLNRAWSP VSHLNSVKNS TELREAYQTC LPLLSEYSTW VGQHKGLYNA YLALKNSAEF 

       130        140        150        160        170        180 
ADYSIAQKKA IENSLRDFEL SGIGLSEEKQ QRYGEIVARL SELNSQFSNN VLDATMGWEK 

       190        200        210        220        230        240 
LIENEAELAG LPESALQAAQ QSAESKGLKG YRFTLEIPSY LPVMTYCENR ALREEMYRAY 

       250        260        270        280        290        300 
ATRASEQGPN AGKWDNSKVM EEILTLRVEL AKLLGFNTYT ELSLATKMAE NPQQVLDFLD 

       310        320        330        340        350        360 
HLAERAKPQG EKELQELKGY CEKEFGVTEL APWDIGFYSE KQKQHLYAIN DEELRPYFPE 

       370        380        390        400        410        420 
NRVISGLFEL IKRIFNIRAV ERKGVDTWHK DVRFFDLIDE NDQLRGSFYL DLYAREHKRG 

       430        440        450        460        470        480 
GAWMDDCIGR KRKLDGSIET PVAYLTCNFN APIGNKPALF THNEVTTLFH EFGHGIHHML 

       490        500        510        520        530        540 
TQIDVSDVAG INGVPWDAVE LPSQFMENWC WEEEALAFIS GHYETGEPLP KEKLTQLLKA 

       550        560        570        580        590        600 
KNFQAAMFIL RQLEFGIFDF RLHHTFDAEK TNQILDTLKS VKSQVAVIKG VDWARAPHSF 

       610        620        630        640        650        660 
SHIFAGGYAA GYYSYLWAEV LSADAYSRFE EEGIFNPITG KSFLDEILTR GGSEEPMELF 

       670        680 
KRFRGREPQL DALLRHKGIM N

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L42023 Genomic DNA. Translation: AAC21882.1.
PIRC64055.
RefSeqNP_438383.2. NC_000907.1.

3D structure databases

ProteinModelPortalP44573.
ModBaseSearch...

Protein-protein interaction databases

STRING71421.HI0214.

Protein family/group databases

MEROPSM03.004.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC21882; AAC21882; HI_0214.
GeneID951121.
KEGGhin:HI0214.
PATRIC20188925. VBIHaeInf48452_0219.

Phylogenomic databases

eggNOGCOG0339.
KOK01414.
OMAFTHDEVT.
ProtClustDBCLSK870199.

Family and domain databases

Gene3D1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOPDA_HAEIN
AccessionPrimary (citable) accession number: P44573
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

SIMILARITY comments

Index of protein domains and families

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