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P44570 (PGPB_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidylglycerophosphatase B

EC=3.1.3.27
Alternative name(s):
Diacylglycerol pyrophosphate phosphatase
Short name=DGPP phosphatase
EC=3.1.3.81
Phosphatidate phosphatase
EC=3.1.3.4
Undecaprenyl pyrophosphate phosphatase
EC=3.6.1.27
Undecaprenyl-diphosphatase
Gene names
Name:pgpB
Ordered Locus Names:HI_0211
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length241 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Also has undecaprenyl pyrophosphate phosphatase activity, required for the biosynthesis of the lipid carrier undecaprenyl phosphate. Can also use lysophosphatidic acid (LPA) and phosphatidylglycerophosphate as substrates. The pattern of activities varies according to subcellular location, PGP phosphatase activity is higher in the cytoplasmic membrane, whereas PA and LPA phosphatase activities are higher in the outer membrane. Activity is independent of a divalent cation ion and insensitive to inhibition by N-ethylmaleimide By similarity.

Catalytic activity

Phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate.

1,2-diacyl-sn-glycerol 3-diphosphate + H2O = 1,2-diacyl-sn-glycerol 3-phosphate + phosphate.

A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.

Pathway

Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2.

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity. Cell outer membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the PA-phosphatase related phosphoesterase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 241241Phosphatidylglycerophosphatase B
PRO_0000058363

Regions

Topological domain1 – 44Cytoplasmic By similarity
Transmembrane5 – 2521Helical; Potential
Topological domain26 – 4520Periplasmic By similarity
Transmembrane46 – 6621Helical; Potential
Topological domain67 – 715Cytoplasmic By similarity
Transmembrane72 – 9221Helical; Potential
Topological domain93 – 15866Periplasmic By similarity
Transmembrane159 – 17921Helical; Potential
Topological domain180 – 1812Cytoplasmic By similarity
Transmembrane182 – 20221Helical; Potential
Topological domain203 – 2119Periplasmic By similarity
Transmembrane212 – 23221Helical; Potential
Topological domain233 – 2419Cytoplasmic By similarity
Region94 – 1029Phosphatase sequence motif I
Region157 – 1604Phosphatase sequence motif II
Region202 – 21312Phosphatase sequence motif III

Sequences

Sequence LengthMass (Da)Tools
P44570 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 86896C8B066D2A41

FASTA24127,491
        10         20         30         40         50         60 
MFKRLSLYTL LLCLVPFFIW GISYQWHGNS QLTQADYWLY LLTETGSVPY ALITCVLFTL 

        70         80         90        100        110        120 
LFAFLFKNPK QWILGVIVMG ISVIATQAAK TGAKALFEEP RPFTVYLAEQ THSTPENFYK 

       130        140        150        160        170        180 
NDRTLRAEIA KNFYSMDAIT PAWLVHHYEN ETGYSFPSGH TIFAATWLML AVGFTQLLGN 

       190        200        210        220        230        240 
RSFKAKLLVV GIAVWGLLML ISRVRLGMHY PIDLLVATLL AWLINSIIFA FLKKKAIFVM 


K 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC21879.1.
PIRI64054.
RefSeqNP_438379.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44570.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0211.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC21879; AAC21879; HI_0211.
GeneID951120.
KEGGhin:HI0211.
PATRIC20188917. VBIHaeInf48452_0215.

Phylogenomic databases

eggNOGCOG0671.
KOK01096.
OMAGMHYPID.
OrthoDBEOG60CWKV.
ProtClustDBCLSK870197.

Enzyme and pathway databases

UniPathwayUPA00084; UER00504.

Family and domain databases

Gene3D1.20.144.10. 1 hit.
InterProIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamPF01569. PAP2. 1 hit.
[Graphical view]
SMARTSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMSSF48317. SSF48317. 2 hits.
ProtoNetSearch...

Entry information

Entry namePGPB_HAEIN
AccessionPrimary (citable) accession number: P44570
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names