SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P44570

- PGPB_HAEIN

UniProt

P44570 - PGPB_HAEIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Phosphatidylglycerophosphatase B
Gene
pgpB, HI_0211
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Also has undecaprenyl pyrophosphate phosphatase activity, required for the biosynthesis of the lipid carrier undecaprenyl phosphate. Can also use lysophosphatidic acid (LPA) and phosphatidylglycerophosphate as substrates. The pattern of activities varies according to subcellular location, PGP phosphatase activity is higher in the cytoplasmic membrane, whereas PA and LPA phosphatase activities are higher in the outer membrane. Activity is independent of a divalent cation ion and insensitive to inhibition by N-ethylmaleimide By similarity.

Catalytic activityi

Phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate.
1,2-diacyl-sn-glycerol 3-diphosphate + H2O = 1,2-diacyl-sn-glycerol 3-phosphate + phosphate.
A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.
Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.

Pathwayi

GO - Molecular functioni

  1. diacylglycerol diphosphate phosphatase activity Source: UniProtKB-EC
  2. phosphatidate phosphatase activity Source: UniProtKB-EC
  3. phosphatidylglycerophosphatase activity Source: UniProtKB-EC
  4. undecaprenyl-diphosphatase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. phosphatidylglycerol biosynthetic process Source: UniProtKB-UniPathway
  2. phospholipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism, Phospholipid degradation, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00084; UER00504.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylglycerophosphatase B (EC:3.1.3.27)
Alternative name(s):
Diacylglycerol pyrophosphate phosphatase (EC:3.1.3.81)
Short name:
DGPP phosphatase
Phosphatidate phosphatase (EC:3.1.3.4)
Undecaprenyl pyrophosphate phosphatase (EC:3.6.1.27)
Undecaprenyl-diphosphatase
Gene namesi
Name:pgpB
Ordered Locus Names:HI_0211
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 44Cytoplasmic By similarity
Transmembranei5 – 2521Helical; Reviewed prediction
Add
BLAST
Topological domaini26 – 4520Periplasmic By similarity
Add
BLAST
Transmembranei46 – 6621Helical; Reviewed prediction
Add
BLAST
Topological domaini67 – 715Cytoplasmic By similarity
Transmembranei72 – 9221Helical; Reviewed prediction
Add
BLAST
Topological domaini93 – 15866Periplasmic By similarity
Add
BLAST
Transmembranei159 – 17921Helical; Reviewed prediction
Add
BLAST
Topological domaini180 – 1812Cytoplasmic By similarity
Transmembranei182 – 20221Helical; Reviewed prediction
Add
BLAST
Topological domaini203 – 2119Periplasmic By similarity
Transmembranei212 – 23221Helical; Reviewed prediction
Add
BLAST
Topological domaini233 – 2419Cytoplasmic By similarity

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Phosphatidylglycerophosphatase B
PRO_0000058363Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0211.

Structurei

3D structure databases

ProteinModelPortaliP44570.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1029Phosphatase sequence motif I
Regioni157 – 1604Phosphatase sequence motif II
Regioni202 – 21312Phosphatase sequence motif III
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0671.
KOiK01096.
OMAiGMHYPID.
OrthoDBiEOG60CWKV.
PhylomeDBiP44570.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 2 hits.

Sequencei

Sequence statusi: Complete.

P44570-1 [UniParc]FASTAAdd to Basket

« Hide

MFKRLSLYTL LLCLVPFFIW GISYQWHGNS QLTQADYWLY LLTETGSVPY    50
ALITCVLFTL LFAFLFKNPK QWILGVIVMG ISVIATQAAK TGAKALFEEP 100
RPFTVYLAEQ THSTPENFYK NDRTLRAEIA KNFYSMDAIT PAWLVHHYEN 150
ETGYSFPSGH TIFAATWLML AVGFTQLLGN RSFKAKLLVV GIAVWGLLML 200
ISRVRLGMHY PIDLLVATLL AWLINSIIFA FLKKKAIFVM K 241
Length:241
Mass (Da):27,491
Last modified:November 1, 1995 - v1
Checksum:i86896C8B066D2A41
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21879.1.
PIRiI64054.
RefSeqiNP_438379.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21879; AAC21879; HI_0211.
GeneIDi951120.
KEGGihin:HI0211.
PATRICi20188917. VBIHaeInf48452_0215.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21879.1 .
PIRi I64054.
RefSeqi NP_438379.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44570.
ModBasei Search...

Protein-protein interaction databases

STRINGi 71421.HI0211.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21879 ; AAC21879 ; HI_0211 .
GeneIDi 951120.
KEGGi hin:HI0211.
PATRICi 20188917. VBIHaeInf48452_0215.

Phylogenomic databases

eggNOGi COG0671.
KOi K01096.
OMAi GMHYPID.
OrthoDBi EOG60CWKV.
PhylomeDBi P44570.

Enzyme and pathway databases

UniPathwayi UPA00084 ; UER00504 .

Family and domain databases

Gene3Di 1.20.144.10. 1 hit.
InterProi IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view ]
Pfami PF01569. PAP2. 1 hit.
[Graphical view ]
SMARTi SM00014. acidPPc. 1 hit.
[Graphical view ]
SUPFAMi SSF48317. SSF48317. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiPGPB_HAEIN
AccessioniPrimary (citable) accession number: P44570
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi