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P44570

- PGPB_HAEIN

UniProt

P44570 - PGPB_HAEIN

Protein

Phosphatidylglycerophosphatase B

Gene

pgpB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Also has undecaprenyl pyrophosphate phosphatase activity, required for the biosynthesis of the lipid carrier undecaprenyl phosphate. Can also use lysophosphatidic acid (LPA) and phosphatidylglycerophosphate as substrates. The pattern of activities varies according to subcellular location, PGP phosphatase activity is higher in the cytoplasmic membrane, whereas PA and LPA phosphatase activities are higher in the outer membrane. Activity is independent of a divalent cation ion and insensitive to inhibition by N-ethylmaleimide By similarity.By similarity

    Catalytic activityi

    Phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate.
    1,2-diacyl-sn-glycerol 3-diphosphate + H2O = 1,2-diacyl-sn-glycerol 3-phosphate + phosphate.
    A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.
    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.

    Pathwayi

    GO - Molecular functioni

    1. diacylglycerol diphosphate phosphatase activity Source: UniProtKB-EC
    2. phosphatidate phosphatase activity Source: UniProtKB-EC
    3. phosphatidylglycerophosphatase activity Source: UniProtKB-EC
    4. undecaprenyl-diphosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. phosphatidylglycerol biosynthetic process Source: UniProtKB-UniPathway
    2. phospholipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism, Phospholipid degradation, Phospholipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00084; UER00504.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylglycerophosphatase B (EC:3.1.3.27)
    Alternative name(s):
    Diacylglycerol pyrophosphate phosphatase (EC:3.1.3.81)
    Short name:
    DGPP phosphatase
    Phosphatidate phosphatase (EC:3.1.3.4)
    Undecaprenyl pyrophosphate phosphatase (EC:3.6.1.27)
    Undecaprenyl-diphosphatase
    Gene namesi
    Name:pgpB
    Ordered Locus Names:HI_0211
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Cell inner membrane By similarity; Multi-pass membrane protein By similarity. Cell outer membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. cell outer membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Cell outer membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 241241Phosphatidylglycerophosphatase BPRO_0000058363Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0211.

    Structurei

    3D structure databases

    ProteinModelPortaliP44570.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 44CytoplasmicBy similarity
    Topological domaini26 – 4520PeriplasmicBy similarityAdd
    BLAST
    Topological domaini67 – 715CytoplasmicBy similarity
    Topological domaini93 – 15866PeriplasmicBy similarityAdd
    BLAST
    Topological domaini180 – 1812CytoplasmicBy similarity
    Topological domaini203 – 2119PeriplasmicBy similarity
    Topological domaini233 – 2419CytoplasmicBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei46 – 6621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei72 – 9221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei182 – 20221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei212 – 23221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1029Phosphatase sequence motif I
    Regioni157 – 1604Phosphatase sequence motif II
    Regioni202 – 21312Phosphatase sequence motif IIIAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0671.
    KOiK01096.
    OMAiGMHYPID.
    OrthoDBiEOG60CWKV.
    PhylomeDBiP44570.

    Family and domain databases

    Gene3Di1.20.144.10. 1 hit.
    InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
    [Graphical view]
    PfamiPF01569. PAP2. 1 hit.
    [Graphical view]
    SMARTiSM00014. acidPPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48317. SSF48317. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    P44570-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFKRLSLYTL LLCLVPFFIW GISYQWHGNS QLTQADYWLY LLTETGSVPY    50
    ALITCVLFTL LFAFLFKNPK QWILGVIVMG ISVIATQAAK TGAKALFEEP 100
    RPFTVYLAEQ THSTPENFYK NDRTLRAEIA KNFYSMDAIT PAWLVHHYEN 150
    ETGYSFPSGH TIFAATWLML AVGFTQLLGN RSFKAKLLVV GIAVWGLLML 200
    ISRVRLGMHY PIDLLVATLL AWLINSIIFA FLKKKAIFVM K 241
    Length:241
    Mass (Da):27,491
    Last modified:November 1, 1995 - v1
    Checksum:i86896C8B066D2A41
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21879.1.
    PIRiI64054.
    RefSeqiNP_438379.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC21879; AAC21879; HI_0211.
    GeneIDi951120.
    KEGGihin:HI0211.
    PATRICi20188917. VBIHaeInf48452_0215.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21879.1 .
    PIRi I64054.
    RefSeqi NP_438379.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44570.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0211.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC21879 ; AAC21879 ; HI_0211 .
    GeneIDi 951120.
    KEGGi hin:HI0211.
    PATRICi 20188917. VBIHaeInf48452_0215.

    Phylogenomic databases

    eggNOGi COG0671.
    KOi K01096.
    OMAi GMHYPID.
    OrthoDBi EOG60CWKV.
    PhylomeDBi P44570.

    Enzyme and pathway databases

    UniPathwayi UPA00084 ; UER00504 .

    Family and domain databases

    Gene3Di 1.20.144.10. 1 hit.
    InterProi IPR000326. P_Acid_Pase_2/haloperoxidase.
    [Graphical view ]
    Pfami PF01569. PAP2. 1 hit.
    [Graphical view ]
    SMARTi SM00014. acidPPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48317. SSF48317. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiPGPB_HAEIN
    AccessioniPrimary (citable) accession number: P44570
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3