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P44557

- FRMA_HAEIN

UniProt

P44557 - FRMA_HAEIN

Protein

S-(hydroxymethyl)glutathione dehydrogenase

Gene

frmA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.
    An alcohol + NAD+ = an aldehyde or ketone + NADH.

    Cofactori

    Binds 2 zinc ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi49 – 491Zinc 1; catalyticBy similarity
    Metal bindingi71 – 711Zinc 1; catalyticBy similarity
    Metal bindingi101 – 1011Zinc 2By similarity
    Metal bindingi104 – 1041Zinc 2By similarity
    Metal bindingi107 – 1071Zinc 2By similarity
    Metal bindingi115 – 1151Zinc 2By similarity
    Metal bindingi178 – 1781Zinc 1; catalyticBy similarity

    GO - Molecular functioni

    1. alcohol dehydrogenase (NAD) activity Source: UniProtKB-EC
    2. S-(hydroxymethyl)glutathione dehydrogenase activity Source: UniProtKB-EC
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. ethanol oxidation Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284)
    Alternative name(s):
    Alcohol dehydrogenase class-3 (EC:1.1.1.1)
    Alcohol dehydrogenase class-III
    Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-)
    Short name:
    FALDH
    Short name:
    FDH
    Short name:
    GSH-FDH
    Gene namesi
    Name:frmA
    Synonyms:adhC
    Ordered Locus Names:HI_0185
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 378378S-(hydroxymethyl)glutathione dehydrogenasePRO_0000160776Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0185.

    Structurei

    3D structure databases

    ProteinModelPortaliP44557.
    SMRiP44557. Positions 7-377.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1062.
    KOiK00121.
    OMAiKTNLCGS.
    OrthoDBiEOG6K9QDH.
    PhylomeDBiP44557.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProiIPR014183. ADH_3.
    IPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR002328. ADH_Zn_CS.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11695. PTHR11695. 1 hit.
    PfamiPF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50129. SSF50129. 2 hits.
    TIGRFAMsiTIGR02818. adh_III_F_hyde. 1 hit.
    PROSITEiPS00059. ADH_ZINC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P44557-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEIKQINSTI KSRAAVAFAP NQPLQIVEID VEMPRKGEVL IRNTHTGVCH    50
    TDAFTLSGSD PEGVFPVVLG HEGAGVVVAV GEGVLSVKPG DHVIPLYTAE 100
    CGECEFCRSG KTNLCVSVRD TQGKGLMPDC TTRFSYQGQP IYHYMGCSTF 150
    SEYSVVAEVS LAKINPEANH EQVCLLGCGV TTGIGAVHNT AKVQEGDSVA 200
    VFGLGAIGLA VVQGARQAKA GRIIAIDTNP AKFELAKQFG ATDCLNPNDY 250
    DKPIKDVLLD INKWGIDHTF ECIGNVNVMR QALESAHRGW GQSIIIGVAG 300
    AGQEISTRPF QLVTGRVWKG SAFGGVKGRS ELPQMVEDSM KGDIQLEPFV 350
    THTMPLDKIN EAFELMHEGK SIRTVIHY 378
    Length:378
    Mass (Da):40,651
    Last modified:November 1, 1995 - v1
    Checksum:iA68677243681165E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21854.1.
    PIRiH64052.
    RefSeqiNP_438353.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC21854; AAC21854; HI_0185.
    GeneIDi951091.
    KEGGihin:HI0185.
    PATRICi20188865. VBIHaeInf48452_0189.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21854.1 .
    PIRi H64052.
    RefSeqi NP_438353.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44557.
    SMRi P44557. Positions 7-377.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0185.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC21854 ; AAC21854 ; HI_0185 .
    GeneIDi 951091.
    KEGGi hin:HI0185.
    PATRICi 20188865. VBIHaeInf48452_0189.

    Phylogenomic databases

    eggNOGi COG1062.
    KOi K00121.
    OMAi KTNLCGS.
    OrthoDBi EOG6K9QDH.
    PhylomeDBi P44557.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProi IPR014183. ADH_3.
    IPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR002328. ADH_Zn_CS.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11695. PTHR11695. 1 hit.
    Pfami PF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50129. SSF50129. 2 hits.
    TIGRFAMsi TIGR02818. adh_III_F_hyde. 1 hit.
    PROSITEi PS00059. ADH_ZINC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiFRMA_HAEIN
    AccessioniPrimary (citable) accession number: P44557
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3