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P44557 (FRMA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
S-(hydroxymethyl)glutathione dehydrogenase

EC=1.1.1.284
Alternative name(s):
Alcohol dehydrogenase class-3
EC=1.1.1.1
Alcohol dehydrogenase class-III
Glutathione-dependent formaldehyde dehydrogenase
Short name=FALDH
Short name=FDH
Short name=GSH-FDH
EC=1.1.1.-
Gene names
Name:frmA
Synonyms:adhC
Ordered Locus Names:HI_0185
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processethanol oxidation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionS-(hydroxymethyl)glutathione dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

alcohol dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: UniProtKB-EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 378378S-(hydroxymethyl)glutathione dehydrogenase
PRO_0000160776

Sites

Metal binding491Zinc 1; catalytic By similarity
Metal binding711Zinc 1; catalytic By similarity
Metal binding1011Zinc 2 By similarity
Metal binding1041Zinc 2 By similarity
Metal binding1071Zinc 2 By similarity
Metal binding1151Zinc 2 By similarity
Metal binding1781Zinc 1; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
P44557 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: A68677243681165E

FASTA37840,651
        10         20         30         40         50         60 
MEIKQINSTI KSRAAVAFAP NQPLQIVEID VEMPRKGEVL IRNTHTGVCH TDAFTLSGSD 

        70         80         90        100        110        120 
PEGVFPVVLG HEGAGVVVAV GEGVLSVKPG DHVIPLYTAE CGECEFCRSG KTNLCVSVRD 

       130        140        150        160        170        180 
TQGKGLMPDC TTRFSYQGQP IYHYMGCSTF SEYSVVAEVS LAKINPEANH EQVCLLGCGV 

       190        200        210        220        230        240 
TTGIGAVHNT AKVQEGDSVA VFGLGAIGLA VVQGARQAKA GRIIAIDTNP AKFELAKQFG 

       250        260        270        280        290        300 
ATDCLNPNDY DKPIKDVLLD INKWGIDHTF ECIGNVNVMR QALESAHRGW GQSIIIGVAG 

       310        320        330        340        350        360 
AGQEISTRPF QLVTGRVWKG SAFGGVKGRS ELPQMVEDSM KGDIQLEPFV THTMPLDKIN 

       370 
EAFELMHEGK SIRTVIHY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC21854.1.
PIRH64052.
RefSeqNP_438353.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44557.
SMRP44557. Positions 7-377.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0185.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC21854; AAC21854; HI_0185.
GeneID951091.
KEGGhin:HI0185.
PATRIC20188865. VBIHaeInf48452_0189.

Phylogenomic databases

eggNOGCOG1062.
KOK00121.
OMARCVVDMS.
OrthoDBEOG6K9QDH.
ProtClustDBCLSK2393140.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProIPR014183. ADH_3.
IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11695. PTHR11695. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. SSF50129. 2 hits.
TIGRFAMsTIGR02818. adh_III_F_hyde. 1 hit.
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFRMA_HAEIN
AccessionPrimary (citable) accession number: P44557
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 13, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names