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P44554

- NAGK_HAEIN

UniProt

P44554 - NAGK_HAEIN

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Protein

N-acetyl-D-glucosamine kinase

Gene

nagK

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.UniRule annotation

Catalytic activityi

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi157 – 1571ZincUniRule annotation
Metal bindingi178 – 1781ZincUniRule annotation
Metal bindingi180 – 1801ZincUniRule annotation
Metal bindingi185 – 1851ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 118ATPUniRule annotation
Nucleotide bindingi133 – 1408ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. N-acetylglucosamine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. N-acetylglucosamine metabolic process Source: UniProtKB-HAMAP
  2. peptidoglycan turnover Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00544.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-D-glucosamine kinaseUniRule annotation (EC:2.7.1.59UniRule annotation)
Alternative name(s):
GlcNAc kinaseUniRule annotation
Gene namesi
Name:nagKUniRule annotation
Ordered Locus Names:HI_0182
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304N-acetyl-D-glucosamine kinasePRO_0000095719Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0182.

Structurei

3D structure databases

ProteinModelPortaliP44554.
SMRiP44554. Positions 1-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ROK (NagC/XylR) family. NagK subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1940.
KOiK00884.
OMAiPEIVAQW.
OrthoDBiEOG61P6P0.
PhylomeDBiP44554.

Family and domain databases

HAMAPiMF_01271. GlcNAc_kinase.
InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44554-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYYGLDIGGT KIELAVFNEK LEKLYSERVP TPKTDYEEWL NTIVDLVNRA
60 70 80 90 100
DEKFGEVGTV GLGVPGFVNQ QTGLAEIANI RVADNKPILC DLSTRLGREV
110 120 130 140 150
RAENDANCFA LSEAWDTENQ QYSTVLGLIL GTGFGGGFVL NGKVHSGQVG
160 170 180 190 200
MAGELGHLQL NYHALKLLGW DNAPIYQCGC GNKACLDNYL SGRGFEMLYQ
210 220 230 240 250
DLKGETLSAR KIINLFYQSN ESAVDFVNLF VELAAISIGN IITAFDPHMI
260 270 280 290 300
VLGGGLSNFD YLYEALPKAL PPHLMRKAKV PPIKKAKHGD SGGVRGAAAL

FLTK
Length:304
Mass (Da):33,107
Last modified:November 28, 2006 - v2
Checksum:i97E174C5EF48CB7F
GO

Sequence cautioni

The sequence AAC21851.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21851.1. Different initiation.
PIRiH64144.
RefSeqiNP_438350.2. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21851; AAC21851; HI_0182.
GeneIDi951092.
KEGGihin:HI0182.
PATRICi20188859. VBIHaeInf48452_0186.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21851.1 . Different initiation.
PIRi H64144.
RefSeqi NP_438350.2. NC_000907.1.

3D structure databases

ProteinModelPortali P44554.
SMRi P44554. Positions 1-303.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0182.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21851 ; AAC21851 ; HI_0182 .
GeneIDi 951092.
KEGGi hin:HI0182.
PATRICi 20188859. VBIHaeInf48452_0186.

Phylogenomic databases

eggNOGi COG1940.
KOi K00884.
OMAi PEIVAQW.
OrthoDBi EOG61P6P0.
PhylomeDBi P44554.

Enzyme and pathway databases

UniPathwayi UPA00544 .

Family and domain databases

HAMAPi MF_01271. GlcNAc_kinase.
InterProi IPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view ]
Pfami PF00480. ROK. 1 hit.
[Graphical view ]
PROSITEi PS01125. ROK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiNAGK_HAEIN
AccessioniPrimary (citable) accession number: P44554
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 28, 2006
Last modified: October 1, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3