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P44554

- NAGK_HAEIN

UniProt

P44554 - NAGK_HAEIN

Protein

N-acetyl-D-glucosamine kinase

Gene

nagK

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (28 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.UniRule annotation

    Catalytic activityi

    ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi157 – 1571ZincUniRule annotation
    Metal bindingi178 – 1781ZincUniRule annotation
    Metal bindingi180 – 1801ZincUniRule annotation
    Metal bindingi185 – 1851ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi4 – 118ATPUniRule annotation
    Nucleotide bindingi133 – 1408ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. N-acetylglucosamine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. N-acetylglucosamine metabolic process Source: UniProtKB-HAMAP
    2. peptidoglycan turnover Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00544.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetyl-D-glucosamine kinaseUniRule annotation (EC:2.7.1.59UniRule annotation)
    Alternative name(s):
    GlcNAc kinaseUniRule annotation
    Gene namesi
    Name:nagKUniRule annotation
    Ordered Locus Names:HI_0182
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 304304N-acetyl-D-glucosamine kinasePRO_0000095719Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0182.

    Structurei

    3D structure databases

    ProteinModelPortaliP44554.
    SMRiP44554. Positions 1-303.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ROK (NagC/XylR) family. NagK subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1940.
    KOiK00884.
    OMAiPEIVAQW.
    OrthoDBiEOG61P6P0.
    PhylomeDBiP44554.

    Family and domain databases

    HAMAPiMF_01271. GlcNAc_kinase.
    InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
    IPR000600. ROK.
    [Graphical view]
    PfamiPF00480. ROK. 1 hit.
    [Graphical view]
    PROSITEiPS01125. ROK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P44554-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYYGLDIGGT KIELAVFNEK LEKLYSERVP TPKTDYEEWL NTIVDLVNRA    50
    DEKFGEVGTV GLGVPGFVNQ QTGLAEIANI RVADNKPILC DLSTRLGREV 100
    RAENDANCFA LSEAWDTENQ QYSTVLGLIL GTGFGGGFVL NGKVHSGQVG 150
    MAGELGHLQL NYHALKLLGW DNAPIYQCGC GNKACLDNYL SGRGFEMLYQ 200
    DLKGETLSAR KIINLFYQSN ESAVDFVNLF VELAAISIGN IITAFDPHMI 250
    VLGGGLSNFD YLYEALPKAL PPHLMRKAKV PPIKKAKHGD SGGVRGAAAL 300
    FLTK 304
    Length:304
    Mass (Da):33,107
    Last modified:November 28, 2006 - v2
    Checksum:i97E174C5EF48CB7F
    GO

    Sequence cautioni

    The sequence AAC21851.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21851.1. Different initiation.
    PIRiH64144.
    RefSeqiNP_438350.2. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC21851; AAC21851; HI_0182.
    GeneIDi951092.
    KEGGihin:HI0182.
    PATRICi20188859. VBIHaeInf48452_0186.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21851.1 . Different initiation.
    PIRi H64144.
    RefSeqi NP_438350.2. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44554.
    SMRi P44554. Positions 1-303.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0182.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC21851 ; AAC21851 ; HI_0182 .
    GeneIDi 951092.
    KEGGi hin:HI0182.
    PATRICi 20188859. VBIHaeInf48452_0186.

    Phylogenomic databases

    eggNOGi COG1940.
    KOi K00884.
    OMAi PEIVAQW.
    OrthoDBi EOG61P6P0.
    PhylomeDBi P44554.

    Enzyme and pathway databases

    UniPathwayi UPA00544 .

    Family and domain databases

    HAMAPi MF_01271. GlcNAc_kinase.
    InterProi IPR023505. N-acetyl-D-glucosamine_kinase.
    IPR000600. ROK.
    [Graphical view ]
    Pfami PF00480. ROK. 1 hit.
    [Graphical view ]
    PROSITEi PS01125. ROK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiNAGK_HAEIN
    AccessioniPrimary (citable) accession number: P44554
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3