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P44538 (NAGB_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glucosamine-6-phosphate deaminase
EC=3.5.99.6
Alternative name(s):
GlcN6P deaminase
Short name=GNPDA
Glucosamine-6-phosphate isomerase
Gene names
Name:nagB
Ordered Locus Names:HI_0141
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length270 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion By similarity. HAMAP MF_01241

Catalytic activity

D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3. HAMAP MF_01241

Enzyme regulation

Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P) By similarity. HAMAP MF_01241

Pathway

Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 5/5. HAMAP MF_01241

Subunit structure

Homohexamer By similarity. HAMAP MF_01241

Sequence similarities

Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 270270Glucosamine-6-phosphate deaminase HAMAP MF_01241
PRO_0000160149

Sites

Active site721Proton acceptor; for enolization step By similarity
Active site1411For ring-opening step By similarity
Active site1431Proton acceptor; for ring-opening step By similarity
Active site1481For ring-opening step By similarity
Site1511Part of the allosteric site By similarity
Site1581Part of the allosteric site By similarity
Site1601Part of the allosteric site By similarity
Site1611Part of the allosteric site By similarity
Site2541Part of the allosteric site By similarity

Sequences

Sequence LengthMass (Da)Tools
P44538 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: D06C651C1A41C235

FASTA27030,501
        10         20         30         40         50         60 
MRFIPLQTEQ QVSCWAAQHI INRINDFKPT AERPFVLGLP TGGTPLKTYQ ELIRLYQAGK 

        70         80         90        100        110        120 
VSFKHVVTFN MDEYVALPEE HPESYHSFMY NNFFNHIDIL PENINILNGN TDDHNAECRR 

       130        140        150        160        170        180 
YEEKIKSYGK IHLFMGGVGV DGHIAFNEPA SSLSSRTRIK TLTQDTLIAN SRFFNNDVTQ 

       190        200        210        220        230        240 
VPKYALTIGV GTLLDAEEVM ILATGHQKAL AVQAAVEGSI NHLWTVSALQ MHRHFLLVCD 

       250        260        270 
EAAQQELKVK TVKYFTELEG AVAGTDYQDK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L42023 Genomic DNA. Translation: AAC21813.1.
PIRF64050.
RefSeqNP_438310.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44538.
SMRP44538. Positions 1-260.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID951053.
GenomeReviewsGene locus HI_0141 in contig L42023_GR.
KEGGhin:HI0141.
NMPDRfig|71421.1.peg.132.
PATRIC20188773. VBIHaeInf48452_0143.
TIGRHI_0141.

Phylogenomic databases

HOGENOMHBG725991.
OMAHSFMYNN.
ProtClustDBPRK00443.

Enzyme and pathway databases

BioCycHINF71421:HI_0141-MONOMER.

Family and domain databases

HAMAPMF_01241. GlcN6P_deamin.
[Tree]
InterProIPR006148. Glc/Gal-6P_isomerase.
IPR004547. Glucosamine6P_isomerase.
IPR018321. Glucosamine6P_isomerase_CS.
[Graphical view]
KOK02564.
PANTHERPTHR11280. NagB. 1 hit.
PfamPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsTIGR00502. NagB. 1 hit.
PROSITEPS01161. GLC_GALNAC_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNAGB_HAEIN
AccessionPrimary (citable) accession number: P44538
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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