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P44521 (GST_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase

EC=2.5.1.18
Gene names
Name:gst
Ordered Locus Names:HI_0111
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the GST superfamily. Beta family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 209209Glutathione S-transferase
PRO_0000185972

Regions

Domain1 – 8181GST N-terminal
Domain87 – 209123GST C-terminal
Region65 – 662Glutathione binding By similarity

Sites

Binding site101Glutathione By similarity
Binding site531Glutathione; via amide nitrogen and carbonyl oxygen By similarity
Binding site1061Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
P44521 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 0FA44B9415B52BEA

FASTA20923,925
        10         20         30         40         50         60 
MKLYGLIGAC SFVPHVALEW VKIRENADYE FEPVTRELIK SPEFLSLNPR GAVPVLVDGD 

        70         80         90        100        110        120 
LVLSQNQAIL HYLDELYPNS KLFGSKTVRD KAKAARWLAF FNSDVHKSFV PLFRLPNYAK 

       130        140        150        160        170        180 
DNETLAHTIR QQAVEQILDQ LAVANEHLES HIYFGENISV ADAYLYIMLN WCKAVKIDFS 

       190        200 
HLTQLSAFMQ RVETDQAVEN VRKSEELKV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC21788.1.
PIRA64049.
RefSeqNP_438285.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44521.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0111.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC21788; AAC21788; HI_0111.
GeneID951011.
KEGGhin:HI0111.
PATRIC20188691. VBIHaeInf48452_0115.

Phylogenomic databases

eggNOGCOG0625.
KOK00799.
OMARENADYE.
OrthoDBEOG6H1Q01.
ProtClustDBCLSK892357.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGST_HAEIN
AccessionPrimary (citable) accession number: P44521
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names