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P44503 (THRC_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Threonine synthase

Short name=TS
EC=4.2.3.1
Gene names
Name:thrC
Ordered Locus Names:HI_0087
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine By similarity.

Catalytic activity

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.

Sequence similarities

Belongs to the threonine synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis
   LigandPyridoxal phosphate
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processthreonine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionpyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

threonine synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 425425Threonine synthase
PRO_0000185632

Amino acid modifications

Modified residue1051N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P44503 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 2CC222DD201F09E0

FASTA42546,682
        10         20         30         40         50         60 
MNLYNIKHPE EQVTFSQAVR QGLGRDQGLF FPEVIPQLNN INELLELPLV ERSQKILGAL 

        70         80         90        100        110        120 
IDGELPQATL DAMVKNAFTF PAPLEKVEEN IYALELFHGP TLAFKDFGGR FMAQALAAVR 

       130        140        150        160        170        180 
GDGKITILTA TSGDTGAAVA HAFYGLENIN VVILYPKGKI SPLQEKLFCT LGGNIRTVAI 

       190        200        210        220        230        240 
NADFDACQAL VKQAFDDVEL RQAIGLNSAN SINISRLLAQ VCYYFEAVAQ LPKEKRDNVV 

       250        260        270        280        290        300 
VSVPSGNFGN LTAGLIAKTL GLPIKRFVAS TNANDTVPRY LKSGNWDPKT TVATLSNAMD 

       310        320        330        340        350        360 
VSRPNNWPRV EELFKRNGWD LTDLGSGMLS DSETEDTLKA MQSKGYLCEP HGAIAYQVLK 

       370        380        390        400        410        420 
DQLKASETGI FLCTAHPAKF KESVERILGI QLPLPETLDK HNQLPLLSDE MDNDFAQLRA 


YLLKS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC21765.1.
PIRH64047.
RefSeqNP_438260.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44503.
SMRP44503. Positions 1-423.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0087.

Proteomic databases

PRIDEP44503.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC21765; AAC21765; HI_0087.
GeneID950990.
KEGGhin:HI0087.
PATRIC20188637. VBIHaeInf48452_0088.

Phylogenomic databases

eggNOGCOG0498.
KOK01733.
OMAHGAIAYQ.
OrthoDBEOG65BDJX.
ProtClustDBPRK09225.

Enzyme and pathway databases

UniPathwayUPA00050; UER00065.

Family and domain databases

InterProIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR004450. Thr_synthase_like.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view]
PfamPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMSSF53686. SSF53686. 1 hit.
TIGRFAMsTIGR00260. thrC. 1 hit.
PROSITEPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTHRC_HAEIN
AccessionPrimary (citable) accession number: P44503
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 13, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names