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Protein

Threonine synthase

Gene

thrC

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.By similarity

Catalytic activityi

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactori

Pathwayi: L-threonine biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-threonine from L-aspartate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Bifunctional aspartokinase/homoserine dehydrogenase (thrA)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Bifunctional aspartokinase/homoserine dehydrogenase (thrA)
  4. Homoserine kinase (thrB)
  5. Threonine synthase (thrC)
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Threonine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-92-MONOMER
UniPathwayiUPA00050; UER00065

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthase (EC:4.2.3.1)
Short name:
TS
Gene namesi
Name:thrC
Ordered Locus Names:HI_0087
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001856321 – 425Threonine synthaseAdd BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei105N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PRIDEiP44503

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0087

Structurei

3D structure databases

ProteinModelPortaliP44503
SMRiP44503
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the threonine synthase family.Curated

Phylogenomic databases

eggNOGiENOG4105D98 Bacteria
COG0498 LUCA
KOiK01733
OMAiYNIKHPE
PhylomeDBiP44503

Family and domain databases

Gene3Di3.90.1380.101 hit
InterProiView protein in InterPro
IPR001926 PLP-dep
IPR000634 Ser/Thr_deHydtase_PyrdxlP-BS
IPR029144 Thr_synth_N
IPR037158 Thr_synth_N_sf
IPR004450 Thr_synthase-like
IPR036052 Trypto_synt_PLP_dependent
PfamiView protein in Pfam
PF00291 PALP, 1 hit
PF14821 Thr_synth_N, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR00260 thrC, 1 hit
PROSITEiView protein in PROSITE
PS00165 DEHYDRATASE_SER_THR, 1 hit

Sequencei

Sequence statusi: Complete.

P44503-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLYNIKHPE EQVTFSQAVR QGLGRDQGLF FPEVIPQLNN INELLELPLV
60 70 80 90 100
ERSQKILGAL IDGELPQATL DAMVKNAFTF PAPLEKVEEN IYALELFHGP
110 120 130 140 150
TLAFKDFGGR FMAQALAAVR GDGKITILTA TSGDTGAAVA HAFYGLENIN
160 170 180 190 200
VVILYPKGKI SPLQEKLFCT LGGNIRTVAI NADFDACQAL VKQAFDDVEL
210 220 230 240 250
RQAIGLNSAN SINISRLLAQ VCYYFEAVAQ LPKEKRDNVV VSVPSGNFGN
260 270 280 290 300
LTAGLIAKTL GLPIKRFVAS TNANDTVPRY LKSGNWDPKT TVATLSNAMD
310 320 330 340 350
VSRPNNWPRV EELFKRNGWD LTDLGSGMLS DSETEDTLKA MQSKGYLCEP
360 370 380 390 400
HGAIAYQVLK DQLKASETGI FLCTAHPAKF KESVERILGI QLPLPETLDK
410 420
HNQLPLLSDE MDNDFAQLRA YLLKS
Length:425
Mass (Da):46,682
Last modified:November 1, 1995 - v1
Checksum:i2CC222DD201F09E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC21765.1
PIRiH64047
RefSeqiNP_438260.1, NC_000907.1
WP_005693831.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC21765; AAC21765; HI_0087
GeneIDi950990
KEGGihin:HI0087
PATRICifig|71421.8.peg.88

Similar proteinsi

Entry informationi

Entry nameiTHRC_HAEIN
AccessioniPrimary (citable) accession number: P44503
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome