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P44503

- THRC_HAEIN

UniProt

P44503 - THRC_HAEIN

Protein

Threonine synthase

Gene

thrC

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.By similarity

    Catalytic activityi

    O-phospho-L-homoserine + H2O = L-threonine + phosphate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. pyridoxal phosphate binding Source: InterPro
    2. threonine synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. threonine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Threonine biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00050; UER00065.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Threonine synthase (EC:4.2.3.1)
    Short name:
    TS
    Gene namesi
    Name:thrC
    Ordered Locus Names:HI_0087
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425Threonine synthasePRO_0000185632Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei105 – 1051N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PRIDEiP44503.

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0087.

    Structurei

    3D structure databases

    ProteinModelPortaliP44503.
    SMRiP44503. Positions 1-423.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the threonine synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0498.
    KOiK01733.
    OMAiHGAIAYQ.
    OrthoDBiEOG65BDJX.
    PhylomeDBiP44503.

    Family and domain databases

    Gene3Di3.90.1380.10. 1 hit.
    InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
    IPR029144. Thr_synth_N.
    IPR004450. Thr_synthase_like.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view]
    PfamiPF00291. PALP. 1 hit.
    PF14821. Thr_synth_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF53686. SSF53686. 1 hit.
    TIGRFAMsiTIGR00260. thrC. 1 hit.
    PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P44503-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLYNIKHPE EQVTFSQAVR QGLGRDQGLF FPEVIPQLNN INELLELPLV    50
    ERSQKILGAL IDGELPQATL DAMVKNAFTF PAPLEKVEEN IYALELFHGP 100
    TLAFKDFGGR FMAQALAAVR GDGKITILTA TSGDTGAAVA HAFYGLENIN 150
    VVILYPKGKI SPLQEKLFCT LGGNIRTVAI NADFDACQAL VKQAFDDVEL 200
    RQAIGLNSAN SINISRLLAQ VCYYFEAVAQ LPKEKRDNVV VSVPSGNFGN 250
    LTAGLIAKTL GLPIKRFVAS TNANDTVPRY LKSGNWDPKT TVATLSNAMD 300
    VSRPNNWPRV EELFKRNGWD LTDLGSGMLS DSETEDTLKA MQSKGYLCEP 350
    HGAIAYQVLK DQLKASETGI FLCTAHPAKF KESVERILGI QLPLPETLDK 400
    HNQLPLLSDE MDNDFAQLRA YLLKS 425
    Length:425
    Mass (Da):46,682
    Last modified:November 1, 1995 - v1
    Checksum:i2CC222DD201F09E0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21765.1.
    PIRiH64047.
    RefSeqiNP_438260.1. NC_000907.1.
    WP_005693831.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC21765; AAC21765; HI_0087.
    GeneIDi950990.
    KEGGihin:HI0087.
    PATRICi20188637. VBIHaeInf48452_0088.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21765.1 .
    PIRi H64047.
    RefSeqi NP_438260.1. NC_000907.1.
    WP_005693831.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44503.
    SMRi P44503. Positions 1-423.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0087.

    Proteomic databases

    PRIDEi P44503.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC21765 ; AAC21765 ; HI_0087 .
    GeneIDi 950990.
    KEGGi hin:HI0087.
    PATRICi 20188637. VBIHaeInf48452_0088.

    Phylogenomic databases

    eggNOGi COG0498.
    KOi K01733.
    OMAi HGAIAYQ.
    OrthoDBi EOG65BDJX.
    PhylomeDBi P44503.

    Enzyme and pathway databases

    UniPathwayi UPA00050 ; UER00065 .

    Family and domain databases

    Gene3Di 3.90.1380.10. 1 hit.
    InterProi IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
    IPR029144. Thr_synth_N.
    IPR004450. Thr_synthase_like.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view ]
    Pfami PF00291. PALP. 1 hit.
    PF14821. Thr_synth_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53686. SSF53686. 1 hit.
    TIGRFAMsi TIGR00260. thrC. 1 hit.
    PROSITEi PS00165. DEHYDRATASE_SER_THR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiTHRC_HAEIN
    AccessioniPrimary (citable) accession number: P44503
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3