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P44503

- THRC_HAEIN

UniProt

P44503 - THRC_HAEIN

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Protein
Threonine synthase
Gene
thrC, HI_0087
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine By similarity.

Catalytic activityi

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactori

Pyridoxal phosphate By similarity.

Pathwayi

GO - Molecular functioni

  1. pyridoxal phosphate binding Source: InterPro
  2. threonine synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. threonine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00050; UER00065.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthase (EC:4.2.3.1)
Short name:
TS
Gene namesi
Name:thrC
Ordered Locus Names:HI_0087
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Threonine synthase
PRO_0000185632Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei105 – 1051N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiP44503.

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0087.

Structurei

3D structure databases

ProteinModelPortaliP44503.
SMRiP44503. Positions 1-423.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0498.
KOiK01733.
OMAiHGAIAYQ.
OrthoDBiEOG65BDJX.
PhylomeDBiP44503.

Family and domain databases

Gene3Di3.90.1380.10. 1 hit.
InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR029144. Thr_synth_N.
IPR004450. Thr_synthase_like.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
PF14821. Thr_synth_N. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00260. thrC. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44503-1 [UniParc]FASTAAdd to Basket

« Hide

MNLYNIKHPE EQVTFSQAVR QGLGRDQGLF FPEVIPQLNN INELLELPLV    50
ERSQKILGAL IDGELPQATL DAMVKNAFTF PAPLEKVEEN IYALELFHGP 100
TLAFKDFGGR FMAQALAAVR GDGKITILTA TSGDTGAAVA HAFYGLENIN 150
VVILYPKGKI SPLQEKLFCT LGGNIRTVAI NADFDACQAL VKQAFDDVEL 200
RQAIGLNSAN SINISRLLAQ VCYYFEAVAQ LPKEKRDNVV VSVPSGNFGN 250
LTAGLIAKTL GLPIKRFVAS TNANDTVPRY LKSGNWDPKT TVATLSNAMD 300
VSRPNNWPRV EELFKRNGWD LTDLGSGMLS DSETEDTLKA MQSKGYLCEP 350
HGAIAYQVLK DQLKASETGI FLCTAHPAKF KESVERILGI QLPLPETLDK 400
HNQLPLLSDE MDNDFAQLRA YLLKS 425
Length:425
Mass (Da):46,682
Last modified:November 1, 1995 - v1
Checksum:i2CC222DD201F09E0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21765.1.
PIRiH64047.
RefSeqiNP_438260.1. NC_000907.1.
WP_005693831.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21765; AAC21765; HI_0087.
GeneIDi950990.
KEGGihin:HI0087.
PATRICi20188637. VBIHaeInf48452_0088.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21765.1 .
PIRi H64047.
RefSeqi NP_438260.1. NC_000907.1.
WP_005693831.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44503.
SMRi P44503. Positions 1-423.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0087.

Proteomic databases

PRIDEi P44503.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21765 ; AAC21765 ; HI_0087 .
GeneIDi 950990.
KEGGi hin:HI0087.
PATRICi 20188637. VBIHaeInf48452_0088.

Phylogenomic databases

eggNOGi COG0498.
KOi K01733.
OMAi HGAIAYQ.
OrthoDBi EOG65BDJX.
PhylomeDBi P44503.

Enzyme and pathway databases

UniPathwayi UPA00050 ; UER00065 .

Family and domain databases

Gene3Di 3.90.1380.10. 1 hit.
InterProi IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR029144. Thr_synth_N.
IPR004450. Thr_synthase_like.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view ]
Pfami PF00291. PALP. 1 hit.
PF14821. Thr_synth_N. 1 hit.
[Graphical view ]
SUPFAMi SSF53686. SSF53686. 1 hit.
TIGRFAMsi TIGR00260. thrC. 1 hit.
PROSITEi PS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiTHRC_HAEIN
AccessioniPrimary (citable) accession number: P44503
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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