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P44502

- METB_HAEIN

UniProt

P44502 - METB_HAEIN

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Protein

Cystathionine gamma-synthase

Gene
metB, HI_0086
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia By similarity.

Catalytic activityi

O(4)-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate.

Cofactori

Binds 1 pyridoxal phosphate per subunit By similarity.

GO - Molecular functioni

  1. cystathionine gamma-synthase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. methionine biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Cystathionine gamma-synthase (EC:2.5.1.48)
Short name:
CGS
Alternative name(s):
O-succinylhomoserine (thiol)-lyase
Gene namesi
Name:metB
Ordered Locus Names:HI_0086
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Cystathionine gamma-synthasePRO_0000114757Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei200 – 2001N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi71421.HI0086.

Structurei

3D structure databases

ProteinModelPortaliP44502.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0626.
KOiK01739.
OMAiTPIFLST.
OrthoDBiEOG67DPN3.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000277. Cys/Met-Metab_PyrdxlP-dep_enz.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11808. PTHR11808. 1 hit.
PfamiPF01053. Cys_Met_Meta_PP. 1 hit.
[Graphical view]
PIRSFiPIRSF001434. CGS. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00868. CYS_MET_METAB_PP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44502-1 [UniParc]FASTAAdd to Basket

« Hide

MTQQYAIDTL LAQAGNRSDE RTGAVSAPIF LSTAYGHCGI GESTGFDYTR    50
TKNPTRTVLE ETIAKLENGD RGFAFSSGMA AIQVLMTLFT APDEWIVSSD 100
VYGGTYRLLD FSYKNNNSVK PVYVNTASAS AIEAAINPNT KAIFIETPSN 150
PLMEECDVVE IAKLAKKHNL MLIVDNTFLT PVLSRPLDLG ADVVIHSGTK 200
YIAGHNDALV GLIVAKGQEL CDRIAYIQNG AGAVLSPFDS WLTIRGMKTL 250
SLRMKRHQEN AQAIAEFLKA QPQVESVLYP NKGGMLSFRL QDEAWVNTFL 300
KSIKLITFAE SLGGTESFIT YPATQTHMDI PESERVARGI TNTLLRFSVG 350
IEDVEDIKAD LLQAFANLK 369
Length:369
Mass (Da):40,371
Last modified:November 1, 1995 - v1
Checksum:iD76A8A03FEAF7A14
GO

Sequence cautioni

The sequence AAC21764.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21764.1. Different initiation.
RefSeqiNP_438259.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21764; AAC21764; HI_0086.
GeneIDi950982.
KEGGihin:HI0086.
PATRICi20188627. VBIHaeInf48452_0087.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21764.1 . Different initiation.
RefSeqi NP_438259.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44502.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0086.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21764 ; AAC21764 ; HI_0086 .
GeneIDi 950982.
KEGGi hin:HI0086.
PATRICi 20188627. VBIHaeInf48452_0087.

Phylogenomic databases

eggNOGi COG0626.
KOi K01739.
OMAi TPIFLST.
OrthoDBi EOG67DPN3.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR000277. Cys/Met-Metab_PyrdxlP-dep_enz.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11808. PTHR11808. 1 hit.
Pfami PF01053. Cys_Met_Meta_PP. 1 hit.
[Graphical view ]
PIRSFi PIRSF001434. CGS. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00868. CYS_MET_METAB_PP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiMETB_HAEIN
AccessioniPrimary (citable) accession number: P44502
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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