Reviewed, UniProtKB/Swiss-Prot P44501 (DDH_HAEIN)

Names and origin

Protein names

Recommended name:
    2-hydroxyacid dehydrogenase homolog
    EC=1.1.1.-

Gene names

Name:	ddh
Ordered Locus Names:	HI0085

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Sequence similarities

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 331	331	2-hydroxyacid dehydrogenase homolog		PRO_0000076021
Sites
	Active site	234	1	By similarity
	Active site	295	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	P44501-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: AB13300E94962566	FASTA	331	37,088
	10 20 30 40 50 60 MKIAIYSTKS YDRKYIELIN AKYNFDLEFF DFMLNESTVR LAEHCEVVCI FVNDNGSRKV 70 80 90 100 110 120 LEKLAALGVK IVALRCAGFN NVDLKAAQEL GIQVVRVPAY SPEAVAEHTI GLMMTLNRRI 130 140 150 160 170 180 HRAYQRTREA NFSLEGLIGF NMYGRTVGVI GTGKIGIAVM RILKGFGMNI LAYDPFKNPV 190 200 210 220 230 240 VEELGGQYVE LDELYAKSHV ITLHCPATPE NYHLLNCEAF AKMKDGVMIV NTSRGSLIDT 250 260 270 280 290 300 QAAIDALKQR KIGALGMDVY ENERDLFFED KSNEVIQDDI FRRLSSCHNV LLTGHQAFLT 310 320 330 EEALTNIADV TLSNIYKLKS GKVCENIVLP S

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L42023 Genomic DNA. Translation: AAC21763.1.
PIR	F64047.
RefSeq	NP_438258.1.
3D structure databases
HSSP	HSSP built from PDB template 1J4A based on UniProtKB P26297.
ModBase	Search...
Genome annotation databases
GeneID	950977.
GenomeReviews	Gene locus HI0085 in contig L42023_GR.
KEGG	hin:HI0085.
NMPDR	fig|71421.1.peg.84.
TIGR	HI0085.
Phylogenomic databases
HOGENOM	P44501.
OMA	P44501. NERELFF.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0085-MON.
Family and domain databases
InterPro	IPR006139. D-isomer_2_OHA_DH. IPR006140. D-isomer_2_OHA_DH_NAD-bd. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF00389. 2-Hacid_dh. 1 hit. PF02826. 2-Hacid_dh_C. 1 hit. [Graphical view]
PROSITE	PS00065. D_2_HYDROXYACID_DH_1. 1 hit. PS00670. D_2_HYDROXYACID_DH_2. 1 hit. PS00671. D_2_HYDROXYACID_DH_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DDH_HAEIN

Accession

Primary (citable) accession number: P44501

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	June 16, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)