Reviewed, UniProtKB/Swiss-Prot P44494 (MUTL_HAEIN)

Names and origin

Protein names

Recommended name:
    DNA mismatch repair protein mutL

Gene names

Name:	mutL
Ordered Locus Names:	HI0067

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	629 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex By similarity.
Sequence similarities	Belongs to the DNA mismatch repair mutL/hexB family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mismatch repair Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro mismatched DNA binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 629	629	DNA mismatch repair protein mutL HAMAP MF_00149		PRO_0000177947

Sequences

	Sequence		Length	Mass (Da)
	P44494-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 0ADC240FD94D1556	FASTA	629	71,623
	10 20 30 40 50 60 MPIKILSPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAN KIQIDIENGG ANLIRIRDNG 70 80 90 100 110 120 CGIPKEELSL ALARHATSKI ADLDDLEAIL SLGFRGEALA SISSVSRLTL TSRTEEQTEA 130 140 150 160 170 180 WQVYAQGRDM ETTIKPASHP VGTTVEVANL FFNTPARRKF LRTDKTEFSH IDEVIRRIAL 190 200 210 220 230 240 TKFNTAFTLT HNGKIIRQYR PAEAINQQLK RVAAICGDDF VKNALRIEWK HDDLHLSGWV 250 260 270 280 290 300 ATPNFSRTQN DLSYCYINGR MVRDKVISHA IRQAYAQYLP TDAYPAFVLF IDLNPHDVDV 310 320 330 340 350 360 NVHPTKHEVR FHQQRLIHDF IYEGISHALN NQEQINWHTD QSAVENHEEN TVREPQPNYS 370 380 390 400 410 420 IRPNRATAGQ NSFAPQYHEK PQQNQPHFSN TPMFPNHVST GYRDYRSDAP SKTEQRLYAE 430 440 450 460 470 480 LLRTLPPTAQ KDISDTAQQN ISDTAKIIST EIIECSSHLR ALSLIENRAL LLQQNQDFFL 490 500 510 520 530 540 LSLEKLQRLQ WQLALKQIQI EQQALLIPIV FRLTESQFQA WQQYSDDFKK IGFEFIENQA 550 560 570 580 590 600 QLRLTLNKVP SALRTQNLQK CVMAMLTRDE NSSSFLTALC AQLECKTFNA LADALNLLSE 610 620 TERLLTQTNR TAFTQLLKPV NWQPLLDEI

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L42023 Genomic DNA. Translation: AAC21745.1.
PIR	E64046.
RefSeq	NP_438240.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	950964.
GenomeReviews	Gene locus HI0067 in contig L42023_GR.
KEGG	hin:HI0067.
NMPDR	fig|71421.1.peg.66.
TIGR	HI0067.
Phylogenomic databases
HOGENOM	P44494.
OMA	EVANLFF
Enzyme and pathway databases
BioCyc	HINF71421:HI_0067-MON.
Family and domain databases
HAMAP	MF_00149. [Tree]
InterPro	IPR003594. ATP_bd_ATPase. IPR002099. DNA_mismatch_repair. IPR013507. DNA_mismatch_repair_C. IPR014762. DNA_mismatch_repair_CS. IPR020667. DNA_mismatch_repair_MutL. IPR014763. DNA_mismatch_repair_N. IPR014790. MutL_C. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit. G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
PANTHER	PTHR10073. DNA_mis_repair. 1 hit.
Pfam	PF01119. DNA_mis_repair. 1 hit. PF02518. HATPase_c. 1 hit. PF08676. MutL_C. 1 hit. [Graphical view]
SMART	SM00387. HATPase_c. 1 hit. SM00853. MutL_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00585. mutl. 1 hit.
PROSITE	PS00058. DNA_MISMATCH_REPAIR_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MUTL_HAEIN

Accession

Primary (citable) accession number: P44494

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 24, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)