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P44493

- AMIB_HAEIN

UniProt

P44493 - AMIB_HAEIN

Protein

Probable N-acetylmuramoyl-L-alanine amidase AmiB

Gene

amiB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Cell-wall hydrolase involved in septum cleavage during cell division.By similarity

    Catalytic activityi

    Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

    GO - Molecular functioni

    1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Cell wall biogenesis/degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable N-acetylmuramoyl-L-alanine amidase AmiB (EC:3.5.1.28)
    Gene namesi
    Name:amiB
    Ordered Locus Names:HI_0066
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Periplasm By similarity

    GO - Cellular componenti

    1. periplasmic space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 432412Probable N-acetylmuramoyl-L-alanine amidase AmiBPRO_0000006464Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0066.

    Structurei

    3D structure databases

    ProteinModelPortaliP44493.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati294 – 33643LysM 1Add
    BLAST
    Repeati387 – 43044LysM 2Add
    BLAST

    Domaini

    LysM repeats are thought to be involved in peptidoglycan binding.

    Sequence similaritiesi

    Contains 2 LysM repeats.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG0860.
    KOiK01448.
    OMAiRIAYMIY.
    OrthoDBiEOG6CP3X3.
    PhylomeDBiP44493.

    Family and domain databases

    Gene3Di3.10.350.10. 2 hits.
    3.40.630.40. 2 hits.
    InterProiIPR002508. CW_Hdrlase/autolysin_cat.
    IPR018392. LysM_dom.
    [Graphical view]
    PfamiPF01520. Amidase_3. 1 hit.
    PF01476. LysM. 2 hits.
    [Graphical view]
    SMARTiSM00646. Ami_3. 1 hit.
    SM00257. LysM. 2 hits.
    [Graphical view]
    SUPFAMiSSF54106. SSF54106. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P44493-1 [UniParc]FASTAAdd to Basket

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    MKTKILFFLF FSTFSFSIFA APITIAIDPG HGGKDPGAIS RNLGIYEKNV    50
    TLSIAKELKA LLDKDPHFRG VLTRKSDYYI SVPERSEIAR KFKANYLISI 100
    HADSSKSPDR RGASVWVLSN RRANDEMGQW LEDDEKRSEL LGGAGKVLSH 150
    NNDKYLDQTV LDLQFGHSQR TGYVLGEHIL HHFAKVTTLS RSTPQHASLG 200
    VLRSPDIPSV LVETGFLSNS EEEKKLNSQT YRRRIAYMIY EGLVAFHSGK 250
    TNTLVKDNLV QNIKQNDIKK SGKNNRTSEQ NINEDNIKDS GIRHIVKKGE 300
    SLGSLSNKYH VKVSDIIKLN QLKRKTLWLN ESIKIPDNVE IKNKSLTIKE 350
    NDFHKKQNSL VNNTNKDLKK EKNTQTNNQK NIIPLYHKVT KNQTLYAISR 400
    EYNIPVNILL SLNPHLKNGK VITGQKIKLR EK 432
    Length:432
    Mass (Da):49,109
    Last modified:November 1, 1995 - v1
    Checksum:i008D918A0E1EE81D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21744.1.
    PIRiD64046.
    RefSeqiNP_438239.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC21744; AAC21744; HI_0066.
    GeneIDi950965.
    KEGGihin:HI0066.
    PATRICi20188587. VBIHaeInf48452_0067.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21744.1 .
    PIRi D64046.
    RefSeqi NP_438239.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44493.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0066.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC21744 ; AAC21744 ; HI_0066 .
    GeneIDi 950965.
    KEGGi hin:HI0066.
    PATRICi 20188587. VBIHaeInf48452_0067.

    Phylogenomic databases

    eggNOGi COG0860.
    KOi K01448.
    OMAi RIAYMIY.
    OrthoDBi EOG6CP3X3.
    PhylomeDBi P44493.

    Family and domain databases

    Gene3Di 3.10.350.10. 2 hits.
    3.40.630.40. 2 hits.
    InterProi IPR002508. CW_Hdrlase/autolysin_cat.
    IPR018392. LysM_dom.
    [Graphical view ]
    Pfami PF01520. Amidase_3. 1 hit.
    PF01476. LysM. 2 hits.
    [Graphical view ]
    SMARTi SM00646. Ami_3. 1 hit.
    SM00257. LysM. 2 hits.
    [Graphical view ]
    SUPFAMi SSF54106. SSF54106. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiAMIB_HAEIN
    AccessioniPrimary (citable) accession number: P44493
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3