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P44493

- AMIB_HAEIN

UniProt

P44493 - AMIB_HAEIN

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Protein

Probable N-acetylmuramoyl-L-alanine amidase AmiB

Gene

amiB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Cell-wall hydrolase involved in septum cleavage during cell division.By similarity

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

  1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Cell wall biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-acetylmuramoyl-L-alanine amidase AmiB (EC:3.5.1.28)
Gene namesi
Name:amiB
Ordered Locus Names:HI_0066
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Periplasm By similarity

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 432412Probable N-acetylmuramoyl-L-alanine amidase AmiBPRO_0000006464Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0066.

Structurei

3D structure databases

ProteinModelPortaliP44493.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati294 – 33643LysM 1Add
BLAST
Repeati387 – 43044LysM 2Add
BLAST

Domaini

LysM repeats are thought to be involved in peptidoglycan binding.

Sequence similaritiesi

Contains 2 LysM repeats.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG0860.
KOiK01448.
OMAiRIAYMIY.
OrthoDBiEOG6CP3X3.
PhylomeDBiP44493.

Family and domain databases

Gene3Di3.10.350.10. 2 hits.
3.40.630.40. 2 hits.
InterProiIPR002508. CW_Hdrlase/autolysin_cat.
IPR018392. LysM_dom.
[Graphical view]
PfamiPF01520. Amidase_3. 1 hit.
PF01476. LysM. 2 hits.
[Graphical view]
SMARTiSM00646. Ami_3. 1 hit.
SM00257. LysM. 2 hits.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P44493-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTKILFFLF FSTFSFSIFA APITIAIDPG HGGKDPGAIS RNLGIYEKNV
60 70 80 90 100
TLSIAKELKA LLDKDPHFRG VLTRKSDYYI SVPERSEIAR KFKANYLISI
110 120 130 140 150
HADSSKSPDR RGASVWVLSN RRANDEMGQW LEDDEKRSEL LGGAGKVLSH
160 170 180 190 200
NNDKYLDQTV LDLQFGHSQR TGYVLGEHIL HHFAKVTTLS RSTPQHASLG
210 220 230 240 250
VLRSPDIPSV LVETGFLSNS EEEKKLNSQT YRRRIAYMIY EGLVAFHSGK
260 270 280 290 300
TNTLVKDNLV QNIKQNDIKK SGKNNRTSEQ NINEDNIKDS GIRHIVKKGE
310 320 330 340 350
SLGSLSNKYH VKVSDIIKLN QLKRKTLWLN ESIKIPDNVE IKNKSLTIKE
360 370 380 390 400
NDFHKKQNSL VNNTNKDLKK EKNTQTNNQK NIIPLYHKVT KNQTLYAISR
410 420 430
EYNIPVNILL SLNPHLKNGK VITGQKIKLR EK
Length:432
Mass (Da):49,109
Last modified:November 1, 1995 - v1
Checksum:i008D918A0E1EE81D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21744.1.
PIRiD64046.
RefSeqiNP_438239.1. NC_000907.1.
WP_005693856.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21744; AAC21744; HI_0066.
GeneIDi950965.
KEGGihin:HI0066.
PATRICi20188587. VBIHaeInf48452_0067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21744.1 .
PIRi D64046.
RefSeqi NP_438239.1. NC_000907.1.
WP_005693856.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44493.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0066.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21744 ; AAC21744 ; HI_0066 .
GeneIDi 950965.
KEGGi hin:HI0066.
PATRICi 20188587. VBIHaeInf48452_0067.

Phylogenomic databases

eggNOGi COG0860.
KOi K01448.
OMAi RIAYMIY.
OrthoDBi EOG6CP3X3.
PhylomeDBi P44493.

Family and domain databases

Gene3Di 3.10.350.10. 2 hits.
3.40.630.40. 2 hits.
InterProi IPR002508. CW_Hdrlase/autolysin_cat.
IPR018392. LysM_dom.
[Graphical view ]
Pfami PF01520. Amidase_3. 1 hit.
PF01476. LysM. 2 hits.
[Graphical view ]
SMARTi SM00646. Ami_3. 1 hit.
SM00257. LysM. 2 hits.
[Graphical view ]
SUPFAMi SSF54106. SSF54106. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiAMIB_HAEIN
AccessioniPrimary (citable) accession number: P44493
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3