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Protein

Probable N-acetylmuramoyl-L-alanine amidase AmiB

Gene

amiB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cell-wall hydrolase involved in septum cleavage during cell division.By similarity

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Cell wall biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-acetylmuramoyl-L-alanine amidase AmiB (EC:3.5.1.28)
Gene namesi
Name:amiB
Ordered Locus Names:HI_0066
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 432412Probable N-acetylmuramoyl-L-alanine amidase AmiBPRO_0000006464Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0066.

Structurei

3D structure databases

ProteinModelPortaliP44493.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati294 – 33643LysM 1Add
BLAST
Repeati387 – 43044LysM 2Add
BLAST

Domaini

LysM repeats are thought to be involved in peptidoglycan binding.

Sequence similaritiesi

Contains 2 LysM repeats.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG0860.
KOiK01448.
OMAiYNIPVNI.
OrthoDBiEOG6CP3X3.
PhylomeDBiP44493.

Family and domain databases

Gene3Di3.10.350.10. 2 hits.
3.40.630.40. 2 hits.
InterProiIPR002508. CW_Hdrlase/autolysin_cat.
IPR018392. LysM_dom.
[Graphical view]
PfamiPF01520. Amidase_3. 1 hit.
PF01476. LysM. 2 hits.
[Graphical view]
SMARTiSM00646. Ami_3. 1 hit.
SM00257. LysM. 2 hits.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P44493-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTKILFFLF FSTFSFSIFA APITIAIDPG HGGKDPGAIS RNLGIYEKNV
60 70 80 90 100
TLSIAKELKA LLDKDPHFRG VLTRKSDYYI SVPERSEIAR KFKANYLISI
110 120 130 140 150
HADSSKSPDR RGASVWVLSN RRANDEMGQW LEDDEKRSEL LGGAGKVLSH
160 170 180 190 200
NNDKYLDQTV LDLQFGHSQR TGYVLGEHIL HHFAKVTTLS RSTPQHASLG
210 220 230 240 250
VLRSPDIPSV LVETGFLSNS EEEKKLNSQT YRRRIAYMIY EGLVAFHSGK
260 270 280 290 300
TNTLVKDNLV QNIKQNDIKK SGKNNRTSEQ NINEDNIKDS GIRHIVKKGE
310 320 330 340 350
SLGSLSNKYH VKVSDIIKLN QLKRKTLWLN ESIKIPDNVE IKNKSLTIKE
360 370 380 390 400
NDFHKKQNSL VNNTNKDLKK EKNTQTNNQK NIIPLYHKVT KNQTLYAISR
410 420 430
EYNIPVNILL SLNPHLKNGK VITGQKIKLR EK
Length:432
Mass (Da):49,109
Last modified:November 1, 1995 - v1
Checksum:i008D918A0E1EE81D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21744.1.
PIRiD64046.
RefSeqiNP_438239.1. NC_000907.1.
WP_005693856.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21744; AAC21744; HI_0066.
GeneIDi950965.
KEGGihin:HI0066.
PATRICi20188587. VBIHaeInf48452_0067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21744.1.
PIRiD64046.
RefSeqiNP_438239.1. NC_000907.1.
WP_005693856.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP44493.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0066.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC21744; AAC21744; HI_0066.
GeneIDi950965.
KEGGihin:HI0066.
PATRICi20188587. VBIHaeInf48452_0067.

Phylogenomic databases

eggNOGiCOG0860.
KOiK01448.
OMAiYNIPVNI.
OrthoDBiEOG6CP3X3.
PhylomeDBiP44493.

Family and domain databases

Gene3Di3.10.350.10. 2 hits.
3.40.630.40. 2 hits.
InterProiIPR002508. CW_Hdrlase/autolysin_cat.
IPR018392. LysM_dom.
[Graphical view]
PfamiPF01520. Amidase_3. 1 hit.
PF01476. LysM. 2 hits.
[Graphical view]
SMARTiSM00646. Ami_3. 1 hit.
SM00257. LysM. 2 hits.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiAMIB_HAEIN
AccessioniPrimary (citable) accession number: P44493
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 27, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.