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Reviewed, UniProtKB/Swiss-Prot P44491 (LPXK_HAEIN)

Last modified December 15, 2009. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Tetraacyldisaccharide 4'-kinase
    EC=2.7.1.130
Alternative name(s):
    Lipid A 4'-kinase
Gene names
Name: lpxK
Ordered Locus Names: HI0059
OrganismHaemophilus influenzae [Complete proteome] [HAMAP]
Taxonomic identifier727 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) By similarity.

Catalytic activity

ATP + (2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate) = ADP + (2-N,3-O-bis(3-hydroxytetradecanoyl)-4-O-phosphono-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate). HAMAP MF_00409

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6. HAMAP MF_00409

Sequence similarities

Belongs to the lpxK family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 332332Tetraacyldisaccharide 4'-kinase HAMAP MF_00409
PRO_0000190929

Regions

Nucleotide binding53 – 608ATP Potential

Sequences

Sequence LengthMass (Da)Tools
P44491-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: D34D58BF0D480DC7

FASTA33237,607
        10         20         30         40         50         60 
MPFWYSNSKL IWLLSPFSLL FWLISQLRRA LFSLGLKSSY RAPKPVIIVG NLSVGGNGKT 

        70         80         90        100        110        120 
PVVVWLMEEL KKRGLRVGVI SRGYGSKSKT YPLFVTKNTN PIEGGDEPVL IAKRTNAPVV 

       130        140        150        160        170        180 
ISPNRQQAIE LLLSQAECDI IISDDGLQHY QLQRDLEIVV MDAERALGNG FVLPAGPLRE 

       190        200        210        220        230        240 
LPSRLKSVDF VITNGGKNQY SDAVMRLVPH FAINLKTNEK RQLNEFQSGV AIAGIGNPQR 

       250        260        270        280        290        300 
FFTMLEKLGI QLKQTQAFQD HQHFEASQLE KLAENQPLFM TEKDAVKCQS FAKDNWWYVP 

       310        320        330 
VDAEIIEAEK QRENLPHFWA KIDKLVEQYR NG 

« Hide

Cross-references

Sequence databases

L42023 Genomic DNA. Translation: AAC21737.1.
PIRG64141.
RefSeqNP_438232.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID950959.
GenomeReviewsGene locus HI0059 in contig L42023_GR.
KEGGhin:HI0059.
NMPDRfig|71421.1.peg.58.
TIGRHI0059.

Phylogenomic databases

HOGENOMHBG663914.
OMAVILMDDG.

Enzyme and pathway databases

BioCycHINF71421:HI_0059-MON.
BRENDA2.7.1.130. 109.

Family and domain databases

HAMAPMF_00409.
[Tree]
InterProIPR003758. Tetraacyldisaccharide_4-kinase.
[Graphical view]
PfamPF02606. LpxK. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLPXK_HAEIN
AccessionPrimary (citable) accession number: P44491
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: December 15, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents