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P44490 (KDSB_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-deoxy-manno-octulosonate cytidylyltransferase
EC=2.7.7.38
Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthase
Short name=CKS
Short name=CMP-KDO synthase
Gene names
Name:kdsB
Ordered Locus Names:HI_0058
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria By similarity. HAMAP MF_00057

Catalytic activity

CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. HAMAP MF_00057

Pathway

Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1. HAMAP MF_00057

Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP MF_00057

Subcellular location

Cytoplasm Potential HAMAP MF_00057.

Sequence similarities

Belongs to the KdsB family.

Ontologies

Keywords
   Biological processLipopolysaccharide biosynthesis
   Cellular componentCytoplasm
   Molecular functionNucleotidyltransferase
Transferase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processlipopolysaccharide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-deoxy-manno-octulosonate cytidylyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 2542533-deoxy-manno-octulosonate cytidylyltransferase HAMAP MF_00057
PRO_0000188506

Secondary structure

1 ............................................ 254
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P44490 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 2FAC2BB15BD961A2

FASTA25428,255
        10         20         30         40         50         60 
MSFTVIIPAR FASSRLPGKP LADIKGKPMI QHVFEKALQS GASRVIIATD NENVADVAKS 

        70         80         90        100        110        120 
FGAEVCMTSV NHNSGTERLA EVVEKLAIPD NEIIVNIQGD EPLIPPVIVR QVADNLAKFN 

       130        140        150        160        170        180 
VNMASLAVKI HDAEELFNPN AVKVLTDKDG YVLYFSRSVI PYDRDQFMNL QDVQKVQLSD 

       190        200        210        220        230        240 
AYLRHIGIYA YRAGFIKQYV QWAPTQLENL EKLEQLRVLY NGERIHVELA KEVPAVGVDT 

       250 
AEDLEKVRAI LAAN

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L42023 Genomic DNA. Translation: AAC21736.1.
PIRG64045.
RefSeqNP_438231.1. NC_000907.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1VH3X-ray2.70A/B/C2-253[»]
1VICX-ray1.80A/B2-253[»]
3DUVX-ray2.30A/B1-254[»]
ProteinModelPortalP44490.
SMRP44490. Positions 2-254.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID950957.
GenomeReviewsGene locus HI_0058 in contig L42023_GR.
KEGGhin:HI0058.
NMPDRfig|71421.1.peg.57.
PATRIC20188569. VBIHaeInf48452_0058.
TIGRHI_0058.

Phylogenomic databases

HOGENOMHBG637773.
OMAFSRAPLP.
ProtClustDBPRK05450.

Enzyme and pathway databases

BioCycHINF71421:HI_0058-MONOMER.

Family and domain databases

HAMAPMF_00057. CMP-KDO_synth.
[Tree]
InterProIPR003329. Cytidylyl_trans.
IPR004528. KdsB.
[Graphical view]
KOK00979.
PANTHERPTHR21485:SF4. PTHR21485:SF4. 1 hit.
PfamPF02348. CTP_transf_3. 1 hit.
[Graphical view]
TIGRFAMsTIGR00466. KdsB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKDSB_HAEIN
AccessionPrimary (citable) accession number: P44490
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: January 25, 2012
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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