Reviewed, UniProtKB/Swiss-Prot P44489 (UVRC_HAEIN)

Names and origin

Protein names

Recommended name:
    UvrABC system protein C
      Short name=Protein uvrC
Alternative name(s):
    Excinuclease ABC subunit C

Gene names

Name:	uvrC
Ordered Locus Names:	HI0057

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	609 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision By similarity.
Subunit structure	Interacts with uvrB in an incision complex By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the uvrC family. Contains 1 UVR domain.

Ontologies

Keywords
Biological process	DNA damage DNA excision DNA repair SOS response
Cellular component	Cytoplasm
Molecular function	Excision nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	SOS response Inferred from electronic annotation. Source: HAMAP nucleotide-excision repair Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell excinuclease repair complex Inferred from electronic annotation. Source: InterPro
Molecular function	DNA binding Inferred from electronic annotation. Source: HAMAP excinuclease ABC activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 609	609	UvrABC system protein C HAMAP MF_00203		PRO_0000138304
Regions
	Domain	201 – 236	36	UVR

Sequences

	Sequence		Length	Mass (Da)
	P44489-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 049DD9212349017A	FASTA	609	69,609
	10 20 30 40 50 60 MFDAKKFLTD VSHEPGVYRM YDDKDQVIYV GKAKDLKKRL SSYFRKNLSS KKTEALVASI 70 80 90 100 110 120 HHIDTTLTSS ETEALLLEHN FIKLYQPRYN VLLRDDKSYP FILLTKERHQ RITSYRGSKK 130 140 150 160 170 180 FAGEYFGPYP HAGAVRETLS LLQKLFPVRQ CENSVYSNRS RPCLQYQIGR CSAPCVQGYV 190 200 210 220 230 240 SDEEYNQQVE LARLFLQGKD QQVLDYLIGK MEQASRNLDF EQAARYRDQI QAVRSVIEKQ 250 260 270 280 290 300 FVSNERLDDM DIMSIAYQHG LACVQVMFIR QGKVLGNRSY FPKVPANTDL SELTETFVGQ 310 320 330 340 350 360 FYLQGHQGRS IPNSIIVDRQ LAEKSELEQL LSEQAGRKVT IQESVKGDKS KYLQLAQVNA 370 380 390 400 410 420 KAALNVQLKQ SSRMSERYQA LCDLLNLPKI KRMECFDISH TMGNQTVASC VVFNKEGPLK 430 440 450 460 470 480 SDYRRFNIEG ITGGDDYAAM EQVLQKRYER DLEEDKIPDI IFIDGGKGQL NRALNVFQHL 490 500 510 520 530 540 QVKWDKNRPH LIGVAKGVDR RAGQEVLIIS KQDREIHLPD DSLALHLIQH IRDESHNHAI 550 560 570 580 590 600 SGHRKKRQKA FTQSGLETIE GVGAKRRQAL LKYLGGLQGV KKATLDEIAS VPGISPKLAE RIFETLKND

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L42023 Genomic DNA. Translation: AAC21735.1.
PIR	F64045.
RefSeq	NP_438230.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	950955.
GenomeReviews	Gene locus HI0057 in contig L42023_GR.
KEGG	hin:HI0057.
NMPDR	fig|71421.1.peg.56.
TIGR	HI0057.
Phylogenomic databases
HOGENOM	P44489.
OMA	LRDDKSF
Enzyme and pathway databases
BioCyc	HINF71421:HI_0057-MON.
Family and domain databases
HAMAP	MF_00203. [Tree]
InterPro	IPR000445. HhH_motif. IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif. IPR010994. RuvA_2-like. IPR001943. UvrB/C. IPR009055. UvrB_UvrC-bd_C. IPR004791. UvrC_ABC. IPR001162. UvrC_C. IPR000305. UvrC_N. [Graphical view]
Pfam	PF01541. GIY-YIG. 1 hit. PF00633. HHH. 1 hit. PF02151. UVR. 1 hit. PF08459. UvrC_HhH_N. 1 hit. [Graphical view]
SMART	SM00465. GIYc. 1 hit. SM00278. HhH1. 2 hits. [Graphical view]
TIGRFAMs	TIGR00194. uvrC. 1 hit.
PROSITE	PS50151. UVR. 1 hit. PS50164. UVRC_1. 1 hit. PS50165. UVRC_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UVRC_HAEIN

Accession

Primary (citable) accession number: P44489

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 24, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)