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P44480

- ALKH_HAEIN

UniProt

P44480 - ALKH_HAEIN

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Protein

Putative KHG/KDPG aldolase

Gene

eda

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei45 – 451PROSITE-ProRule annotation
Active sitei49 – 491PROSITE-ProRule annotation
Active sitei133 – 1331Schiff-base intermediate with KHG or pyruvatePROSITE-ProRule annotation

GO - Molecular functioni

  1. 2-dehydro-3-deoxy-phosphogluconate aldolase activity Source: UniProtKB-EC
  2. 4-hydroxy-2-oxoglutarate aldolase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00227.
UPA00856; UER00829.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative KHG/KDPG aldolase
Including the following 2 domains:
4-hydroxy-2-oxoglutarate aldolase (EC:4.1.3.16)
Alternative name(s):
2-keto-4-hydroxyglutarate aldolase
Short name:
KHG-aldolase
2-dehydro-3-deoxy-phosphogluconate aldolase (EC:4.1.2.14)
Alternative name(s):
2-keto-3-deoxy-6-phosphogluconate aldolase
Short name:
KDPG-aldolase
Phospho-2-dehydro-3-deoxygluconate aldolase
Phospho-2-keto-3-deoxygluconate aldolase
Gene namesi
Name:eda
Ordered Locus Names:HI_0047
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Putative KHG/KDPG aldolasePRO_0000201041Add
BLAST

Interactioni

Subunit structurei

Homotrimer.

Protein-protein interaction databases

STRINGi71421.HI0047.

Structurei

Secondary structure

1
212
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1511Combined sources
Beta strandi17 – 215Combined sources
Helixi26 – 283Combined sources
Helixi29 – 3810Combined sources
Beta strandi43 – 475Combined sources
Helixi53 – 6311Combined sources
Beta strandi68 – 736Combined sources
Helixi77 – 8610Combined sources
Beta strandi89 – 924Combined sources
Helixi98 – 1069Combined sources
Helixi118 – 1269Combined sources
Beta strandi131 – 1344Combined sources
Turni135 – 1417Combined sources
Helixi142 – 1509Combined sources
Turni151 – 1555Combined sources
Beta strandi157 – 1637Combined sources
Turni166 – 1683Combined sources
Helixi169 – 1735Combined sources
Beta strandi181 – 1833Combined sources
Helixi185 – 1873Combined sources
Helixi189 – 1935Combined sources
Helixi197 – 21115Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VHCX-ray1.89A/B/C/D/E/F2-212[»]
ProteinModelPortaliP44480.
SMRiP44480. Positions 2-212.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP44480.

Family & Domainsi

Sequence similaritiesi

Belongs to the KHG/KDPG aldolase family.Curated

Phylogenomic databases

eggNOGiCOG0800.
KOiK01625.
OMAiYCQELNI.
OrthoDBiEOG67DPKT.
PhylomeDBiP44480.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR000887. Aldlse_KDPG_KHG.
IPR013785. Aldolase_TIM.
[Graphical view]
PfamiPF01081. Aldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01182. eda. 1 hit.
PROSITEiPS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44480-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSYTTQQIIE KLRELKIVPV IALDNADDIL PLADTLAKNG LSVAEITFRS
60 70 80 90 100
EAAADAIRLL RANRPDFLIA AGTVLTAEQV VLAKSSGADF VVTPGLNPKI
110 120 130 140 150
VKLCQDLNFP ITPGVNNPMA IEIALEMGIS AVKFFPAEAS GGVKMIKALL
160 170 180 190 200
GPYAQLQIMP TGGIGLHNIR DYLAIPNIVA CGGSWFVEKK LIQSNNWDEI
210
GRLVREVIDI IK
Length:212
Mass (Da):22,861
Last modified:November 1, 1995 - v1
Checksum:i1D920F34AB4C14E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21725.1.
PIRiA64045.
RefSeqiNP_438220.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21725; AAC21725; HI_0047.
GeneIDi950945.
KEGGihin:HI0047.
PATRICi20188547. VBIHaeInf48452_0047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21725.1 .
PIRi A64045.
RefSeqi NP_438220.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1VHC X-ray 1.89 A/B/C/D/E/F 2-212 [» ]
ProteinModelPortali P44480.
SMRi P44480. Positions 2-212.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0047.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21725 ; AAC21725 ; HI_0047 .
GeneIDi 950945.
KEGGi hin:HI0047.
PATRICi 20188547. VBIHaeInf48452_0047.

Phylogenomic databases

eggNOGi COG0800.
KOi K01625.
OMAi YCQELNI.
OrthoDBi EOG67DPKT.
PhylomeDBi P44480.

Enzyme and pathway databases

UniPathwayi UPA00227 .
UPA00856 ; UER00829 .

Miscellaneous databases

EvolutionaryTracei P44480.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR000887. Aldlse_KDPG_KHG.
IPR013785. Aldolase_TIM.
[Graphical view ]
Pfami PF01081. Aldolase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01182. eda. 1 hit.
PROSITEi PS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (1.89 ANGSTROMS) OF 2-212.

Entry informationi

Entry nameiALKH_HAEIN
AccessioniPrimary (citable) accession number: P44480
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3