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P44480

- ALKH_HAEIN

UniProt

P44480 - ALKH_HAEIN

Protein

Putative KHG/KDPG aldolase

Gene

eda

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
    2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei45 – 451PROSITE-ProRule annotation
    Active sitei49 – 491PROSITE-ProRule annotation
    Active sitei133 – 1331Schiff-base intermediate with KHG or pyruvatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. 2-dehydro-3-deoxy-phosphogluconate aldolase activity Source: UniProtKB-EC
    2. 4-hydroxy-2-oxoglutarate aldolase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    UniPathwayiUPA00227.
    UPA00856; UER00829.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative KHG/KDPG aldolase
    Including the following 2 domains:
    4-hydroxy-2-oxoglutarate aldolase (EC:4.1.3.16)
    Alternative name(s):
    2-keto-4-hydroxyglutarate aldolase
    Short name:
    KHG-aldolase
    2-dehydro-3-deoxy-phosphogluconate aldolase (EC:4.1.2.14)
    Alternative name(s):
    2-keto-3-deoxy-6-phosphogluconate aldolase
    Short name:
    KDPG-aldolase
    Phospho-2-dehydro-3-deoxygluconate aldolase
    Phospho-2-keto-3-deoxygluconate aldolase
    Gene namesi
    Name:eda
    Ordered Locus Names:HI_0047
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 212212Putative KHG/KDPG aldolasePRO_0000201041Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.

    Protein-protein interaction databases

    STRINGi71421.HI0047.

    Structurei

    Secondary structure

    1
    212
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 1511
    Beta strandi17 – 215
    Helixi26 – 283
    Helixi29 – 3810
    Beta strandi43 – 475
    Helixi53 – 6311
    Beta strandi68 – 736
    Helixi77 – 8610
    Beta strandi89 – 924
    Helixi98 – 1069
    Helixi118 – 1269
    Beta strandi131 – 1344
    Turni135 – 1417
    Helixi142 – 1509
    Turni151 – 1555
    Beta strandi157 – 1637
    Turni166 – 1683
    Helixi169 – 1735
    Beta strandi181 – 1833
    Helixi185 – 1873
    Helixi189 – 1935
    Helixi197 – 21115

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1VHCX-ray1.89A/B/C/D/E/F2-212[»]
    ProteinModelPortaliP44480.
    SMRiP44480. Positions 2-212.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP44480.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the KHG/KDPG aldolase family.Curated

    Phylogenomic databases

    eggNOGiCOG0800.
    KOiK01625.
    OMAiYCQELNI.
    OrthoDBiEOG67DPKT.
    PhylomeDBiP44480.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR000887. Aldlse_KDPG_KHG.
    IPR013785. Aldolase_TIM.
    [Graphical view]
    PfamiPF01081. Aldolase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01182. eda. 1 hit.
    PROSITEiPS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
    PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P44480-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYTTQQIIE KLRELKIVPV IALDNADDIL PLADTLAKNG LSVAEITFRS    50
    EAAADAIRLL RANRPDFLIA AGTVLTAEQV VLAKSSGADF VVTPGLNPKI 100
    VKLCQDLNFP ITPGVNNPMA IEIALEMGIS AVKFFPAEAS GGVKMIKALL 150
    GPYAQLQIMP TGGIGLHNIR DYLAIPNIVA CGGSWFVEKK LIQSNNWDEI 200
    GRLVREVIDI IK 212
    Length:212
    Mass (Da):22,861
    Last modified:November 1, 1995 - v1
    Checksum:i1D920F34AB4C14E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21725.1.
    PIRiA64045.
    RefSeqiNP_438220.1. NC_000907.1.
    WP_005693874.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC21725; AAC21725; HI_0047.
    GeneIDi950945.
    KEGGihin:HI0047.
    PATRICi20188547. VBIHaeInf48452_0047.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21725.1 .
    PIRi A64045.
    RefSeqi NP_438220.1. NC_000907.1.
    WP_005693874.1. NC_000907.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1VHC X-ray 1.89 A/B/C/D/E/F 2-212 [» ]
    ProteinModelPortali P44480.
    SMRi P44480. Positions 2-212.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0047.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC21725 ; AAC21725 ; HI_0047 .
    GeneIDi 950945.
    KEGGi hin:HI0047.
    PATRICi 20188547. VBIHaeInf48452_0047.

    Phylogenomic databases

    eggNOGi COG0800.
    KOi K01625.
    OMAi YCQELNI.
    OrthoDBi EOG67DPKT.
    PhylomeDBi P44480.

    Enzyme and pathway databases

    UniPathwayi UPA00227 .
    UPA00856 ; UER00829 .

    Miscellaneous databases

    EvolutionaryTracei P44480.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR000887. Aldlse_KDPG_KHG.
    IPR013785. Aldolase_TIM.
    [Graphical view ]
    Pfami PF01081. Aldolase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01182. eda. 1 hit.
    PROSITEi PS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
    PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
    2. Cited for: X-RAY CRYSTALLOGRAPHY (1.89 ANGSTROMS) OF 2-212.

    Entry informationi

    Entry nameiALKH_HAEIN
    AccessioniPrimary (citable) accession number: P44480
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3