Reviewed, UniProtKB/Swiss-Prot P44472 (Y035_HAEIN)

Names and origin

Protein names

Recommended name:
    Putative transport protein HI0035

Gene names

Ordered Locus Names:

HI0035

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	551 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the AAE transporter (TC 2.A.81) family. YidE subfamily. [View classification] Contains 2 RCK C-terminal domains.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Membrane
Domain	Repeat Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro potassium ion transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	binding Inferred from electronic annotation. Source: InterPro catalytic activity Inferred from electronic annotation. Source: InterPro cation transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 551	551	Putative transport protein HI0035 HAMAP MF_01016		PRO_0000208801
Regions
	Transmembrane	4 – 24	21	Potential
	Transmembrane	28 – 48	21	Potential
	Transmembrane	65 – 85	21	Potential
	Transmembrane	95 – 115	21	Potential
	Transmembrane	157 – 177	21	Potential
	Transmembrane	370 – 390	21	Potential
	Transmembrane	402 – 424	23	Potential
	Transmembrane	438 – 458	21	Potential
	Transmembrane	463 – 483	21	Potential
	Transmembrane	492 – 512	21	Potential
	Transmembrane	529 – 549	21	Potential
	Domain	191 – 275	85	RCK C-terminal 1
	Domain	277 – 360	84	RCK C-terminal 2

Sequences

	Sequence		Length	Mass (Da)
	P44472-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 4550021090CDFA1F	FASTA	551	59,014
	10 20 30 40 50 60 MSDIAITISL LALVAVIGLW IGHWKIRGVG LGIGGVLFGG IIVAHFTNQY GLKLDAHTLH 70 80 90 100 110 120 FVQEFGLILF VYTIGIQVGP GFFSSLRKSG LKLNAFAILI ILLGSIAVVL VHKIADVPLD 130 140 150 160 170 180 IALGIYSGAV TNTPALGAGQ QILAELGVPQ TTVTMGVSYA MAYPFGICGI LLAMWLIRLF 190 200 210 220 230 240 FNVKVDDEAA RFNAESSQDK ESLHNISLKV TNQNLDGLTL IQIPGFSDEE VVCSRLKRDD 250 260 270 280 290 300 MEIVPKASTE IRTNDILQLV GDDNSLAKMR LIIGHEVDAP TVAYSGEIRS ERVVVTNEKV 310 320 330 340 350 360 LGKKIRALGI HQKYGVVISR LNRAGIELVP TGNTTLQFGD VLHMVGRSDV LNQAISVIGN 370 380 390 400 410 420 AQQKLLQVQM LPVFIGIGLG VLVGSIPFYI PGFPVALKLG LAGGPLVVAL ILARIGTIGK 430 440 450 460 470 480 LYWFMPPSAN LALREIGIVL FLAVVGLKSG GSFFDTLVNG SGLEWMGYGI FITFVPLIIV 490 500 510 520 530 540 GTIARLYGKL NYLTICGLLA GSMTDPPALA FANEIKEDNG AAALSYATVY PLVMFLRIMS 550 PQLLAVLLWA A

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L42023 Genomic DNA. Translation: AAC21713.1.
PIR	I64140.
RefSeq	NP_438208.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	950933.
GenomeReviews	Gene locus HI0035 in contig L42023_GR.
KEGG	hin:HI0035.
NMPDR	fig|71421.1.peg.34.
TIGR	HI0035.
Phylogenomic databases
HOGENOM	HBG452396.
OMA	IGLWIGH.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0035-MON.
Family and domain databases
HAMAP	MF_01016. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR006037. RCK_C. IPR006512. YidE_YbjL. [Graphical view]
Pfam	PF06826. Asp-Al_Ex. 2 hits. PF02080. TrkA_C. 2 hits. [Graphical view]
PROSITE	PS51202. RCK_C. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y035_HAEIN

Accession

Primary (citable) accession number: P44472

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	December 15, 2009
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)